5G: Biomaterials for Women's Health
Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Seaglass
About
The tissues of the female reproductive system demonstrate unique functional and mechanical properties, yet female reproductive health has historically been significantly understudied and underfunded. This session will highlight advances in biomaterials and tissue engineering approaches to consider complex, multi-cellular environment of many of these tissues to advance our understanding of reproductive health, disease and age-related changes. Topics include disorders in reproductive tissues (e.g. endometriosis, cancer, premature ovarian insufficiency, infertility, preterm birth), multicellular tissue-level interactions and mechanics in reproductive health, extracellular matrix dynamics and sex-related differences in chronic diseases.
3:45 PM 249. Micromechanical Characterization with AFM Indentation and Viscoelastic Modeling Reveals both Elastic and Viscoelastic Heterogeneities in Ovarian Tissue. Samantha Stewart, Wenquan Ou, PhD, Xiaoming He, PhD, University of Maryland, College Park, College Park, MD, USA.
4:00 PM 250. Multi-Compartment Organoids of the Human Fallopian Tube. Ashleigh Crawford, Isha Bhorkar, Andre Forjaz, Triya Roy, David Schell, Ashley Kiemen, PhD, Ie-Ming Shih, MD, PhD, Tian-Li Wang, PhD, Denis Wirtz, PhD, Johns Hopkins University, Baltimore, MD, USA, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
4:15 PM 251. Designing a Synthetic Scaffold to Support Human. Folliculogenesis in Vivo. Monica Wall, M.S., Ariella Shikanov, PhD, University of Michigan, Ann Arbor, MI, USA.
4:30 252. Developing a Microporous Annealed Particle Hydrogel for Human Ovarian Tissue Encapsulation. Despina Pavlidis, Ariella Shikanov, PhD,University of Michigan, Ann Arbor, MI, USA.
4:45 PM 253. Developing Semi-synthetic Biomaterial Tools to Model the Interface of Endometriotic Lesions & Healthy Tissue. Hannah Theriault, Hannah Kimmel, Kathryn Clancy, PhD, Gregory Underhill, PhD, Brendan Harley, ScD, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
5:00 PM 254. Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for Selective mRNA Delivery to the Placenta. Hannah Safford, Kelsey Swingle, Hannah Geisler, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA.
5:15 PM 255. Co-culture Organoids Recapitulate the Human Menstrual Cycle and Reveal Inflammatory Cascades in Endometriosis. Laura Bahlmann, PhD, Juan Gnecco, PhD, Alexander Brown, PhD, Lauren Baugh, PhD, Jeremy Huang, PhD, Kira Buttery, Clara Ives, Brittany Goods, Victor Hernandez-Gordillo, Doug Lauffenburger, PhD, Megan Loring, Keith Isaacson, MD, Linda Griffith, Bryan Bryson, PhD,
Massachusetts Institute of Technology, Cambridge, MA, USA, Tufts University, Medford, MA, USA, Dartmouth College, Hanover, NH, USA, Newton Wellesley Hospital, Newton, MA, USA, Ragon Institute, Cambridge, MA, USA.5:30 PM 256. Hybrid Poly(ethylene glycol) and Hyaluronic Acid Bioactive Hydrogels for Endometrial Tissue Engineering. Samantha Holt, A. Nihan Kilinc, Christina Kim, Linda Griffith, Massachusetts Institute of Technology, Cambridge, MA, USA.