Poster Session I - Wednesday, April 19th, 6:30 PM - 8:30 PM

Advances and Translation of Self-Assembly Soft Biomaterials

444. Anti-Inflammatory and Initiator-Free Photopolymerized Zwitterionic Hydrogels, Michael Stager, Melissa Krebs, Colorado School of Mines, Golden, CO, USA. P1001

445. Novel Fructose Based Levan Nanoparticles for Receptor Mediated Osteoarthritis Treatment, Jinsil Lee, M.E, Hyeryeon Oh, M.E, Wonil Choi, PhD, Korea Institute of Ceramic Engineering and Technology (KICET), Cheongju, Republic of Korea. P1002

446. Novel Levan Dermal Filler with Hydroxyapatite for Anti-wrinkle Efficacy In Vivo, Hyeryeon Oh, ME, Jin Sil Lee, ME, Won Il Choi, PhD, Korea Institute of Ceramic Engineering and Technology (KICET), Cheongju, Republic of Korea. P1003

447. Development of Peptide Amphiphile micelles targeted to Lymph Node Metastases, Noah Trac, B.Sc, Eun Ji Chung, PhD, University of Southern California, Los Angeles, CA, USA. P1004

Applied Biomaterials for Microphysiological Systems

448. Glioblastoma Microenvironment Modulation via Electrical Stimulation for Cell-to-Cell Functional Pathomechanism, Ji Yeon Lee, PhD, Bon Il Koo, PhD, Trang Huyen Le-Kim, PhD, Yoon Sung Nam, PhD, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. P1005

449. Induced Pluripotent Stem Cell – Derived Synthetic Neural Constructs for Brain Cancer Modeling Apoorva Ramamurthy, M.S., Joydeb Majumder, Elizabeth Torr, William Murphy, University of Wisconsin Madison, Madison, WI, USA. P1006

450. Optimization of Synthetic Matrices for Endothelial Cell Network Formation in Microfluidic Devices, Lauren Pruett, PhD, Matthew Johnson, Priyatanu Roy, PhD, Linda Griffith, PhD, Massachusetts Institute of Technology, Cambridge, MA, USA. P1007

Bioactive Materials for Hard and/or Soft Tissue Regeneration

451. Development of a New 3D Bioprinted Antibiotic Delivery System based on a Cross-linked Gelatin–Alginate Hydrogel, Habib Belaïd, PhD, Adam Mirek, Vincent Cavaillès, PhD, Dorota Lewinska, PhD, Mikhael Bechelany, PhD, European Institute of Membranes, Montpellier, France, Nalecz Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland, Research Institute of Cancerology, Montpellier, France. P1008

452. Fabrication of Radio-Opaque and Macroporous Injectable Calcium Phosphate Cement, Habib Belaïd, PhD, David Cornu, PhD, Vincent Cavaillès, PhD, Mikhael Bechelany, PhD, European Institute of Membranes, Montpellier, France, Research Institute of Cancerology, Montpellier, France. P1009

453. Multifunctional Membrane with Interpenetrating Collagen/AMP Nanofibers for Guided Bone Regeneration, Zhou Ye, Jinhong Dai, Nicholas Fischer, Joseph Rahimi, Hongning Wang, Hooi Pin Chew, Conrado Aparicio, Shengbin Huang1The University of Hong Kong, Hong Kong, Hong Kong, 2Wenzhou Medical University, Wenzhou, China, 3University of Minnesota, Minneapolis, MN, USA, 4Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain. P1010

454. Development of soft-hard inter-regional tissue using a mineralized dECM membrane, Tsuyoshi Kimura, Mika Suzuki, Yoshihide Hashimoto, PhD, Masahiro Okada, PhD, Takuya Matsumoto, PhD, Naoko Nakamura, PhD, Akio Kishida, PhD, Tokyo Medical and Dental University, Tokyo, Japan, Okayama University, Okayama-shi, Japan, 3Shibaura Institute of Technology, Saitama-shi, Japan P1011

455. Osteo-immunomodulating Periosteum for Accelerated Osteogenesis and Angiogenesis, Ho Pan Bei The Hong Kong Polytechnic University, Hong Kong, Hong Kong P1012

456. Promoted myogenesis within 3D bioprinted constructs of MXene-incorporated hyaluronate/gelatin hydrogels, Dong-Wook Han, PhD, Hyo Jung Jo, BE, Hee Jeong Jang, ME, Moon Sung Kang, ME1, Bongju Kim, PhD, Suck Won Hong, PhD, Jong-Chul Park, PhD, 1Pusan National University, Busan, Republic of Korea, 2Seoul National University Dental Hospital, Seoul, Republic of Korea, 3Yonsei University College of Medicine, Seoul, Republic of Korea P1013

457. Cell-adaptable Hierarchical Hydrogel with High Stiffness and Fast Relaxation, Zhinan YANG, Boguang YANG, Zhaoli GAO Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong P1014

458. Strontium Decreases Mitochondrial Reactive Oxygen Species Production in Chondrocyte Spheroids, Adil Akkouch, PhD, Shelby Chaney, MS, Zeena Qiryaqoz, BA Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA P1015

459. Effect of Hot Caliber Rolling on Microstructure and Corrosion Behavior of Bioabsorbable Mg-Sc-Sr alloy, Pedram Sotoudeh Bagha, PhD, Valeria Cardenas, Mehdi Razavi, Kayley Romero 1Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA, 2Department of Materials Science and Engineering, University of Central Florida, Orlando, FL, USA P1016

460. Antimicrobial and antioxidant chitosan-PVA hydrogel hernia mesh loaded with S-nitroso-N acetyl-DL-penicillamine, Ziyu Wang, Ashley Brown, PhD, Arielle Perez, Jessica Gluck, PhD, Martin King, PhD Wilson College of Textiles, North Carolina State University, Raleigh, NC, 27606, Raleigh, NC, USA, Joint Department of Biomedical Engineering, UNC-Chapel Hill & NC State University, Raleigh, NC, 27695, Raleigh, NC, USA, 3Division of Acute Care and Trauma Surgery, UNC Health Hernia Center, Chapel Hill, NC, 27599, Chapel Hill, NC, USA, 4College of Textiles, Donghua University, Songjiang, Shanghai, 201620, China, Shanghai, China P1017

461. In vivo evaluation of bone regeneration in maxillary sinus with a new bioactive glass biomaterial, Isis de Fatima Balderrama, DDS, MSc, PhD student, Guilherme Jose Pimentel Lopes Oliveira, DDS, MSc, PhD, Rafael Silveira Faeda, DDS, MSc, PhD, Iolanda Augusta Fernandes de Matos, DDS, MSc.1, Marina Trevelin Souza, DDS, MSc, PhD.5, Edgar Dutra Zanotto, ME, MSc, PhD.5, Morgana Rodrigues Guimaraes Stabili, DDS, MSc, PhD1, Paulo G. Coelho, DDS, MD, MSc, MBA, PhD.6, Lukasz Witek, MSci, PhD2, Elcio Marcantonio-Junior, DDS, MSc, PhD.1Araraquara School of Dentistry, Sao Paulo State University, Araraquara, Brazil, College of Dentistry, New York University, New York City, NY, USA, School of Dentistry, Federal University of Uberlandia, Uberlandia, Brazil, School of Dentistry, University of Araraquara, Araraquara, Brazil, Federal University of Sao Carlos, Sao Carlos, Brazil, Miller School of Medicine, University of Miami, Miami, FL, USA P1018

462. Multifunctional Gallium Doped Bioactive Glasses: A Targeted Delivery for Antineoplastic Agents and Tissue Repair Against Osteosarcoma, Shirin Hanaei, MSC, Richard Martin, PhD Aston university, Birmingham, United Kingdom P1019

463. Wnt Agonists-Loaded Electrospun Cellulose Acetate Scaffolds For Bone Tissue Engineering Applications, Samir Bello Melo, PhD, Andrea Vargas-Morales, Joeysel Velazquez Mendez, Eduardo Nicolau Lopez, PhD 1University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico, 2Molecular Sciences Research Center, Inc., San Juan, Puerto Rico P1020

464. Technical innovation in bioceramic formula design for regenerative medicine, Ahmed El- Ghannam, Robert Horowitz, University of North Carolina at Charlotte P1021

465. Preparation of co-electrospinning membrane loaded with simvastatin and substance P to accelerate bone regeneration by promoting cell homing, angiogenesis and osteogenesis, Mohammed Al-Baadani, PhD, Kexin Cai, Jinsong Liu School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China P1022

466. Systematic Investigation of Mg Corrosion Affecting the Biological Response- Importance of Metal-Cell Interactions, Jua Kim, PhD, Haobo Pan Shenzhen Institute of Advanced Technology Chinese Academy of Sciences, Shenzhen, China P1023

467. Bioinspired patch platform for translational adhesive technologies, Jingjing Wu, PhD, Hyunwoo Yuk, Xuanhe Zhao Massachusetts Institute of Technology, Cambridge, MA, USA P1024

468. In Vivo Evaluation of OssiMend Bioactive Moldable Scaffold vs. SignaFuse Putty in a Rabbit Femoral Condylar Defect Model, Hui-Chen Chen, PhD1, Shruti Saxena, PhD, Ediha Choudhury, Dan Ammon 1Collagen Matrix Inc., Oakland, NJ, USA P1025

469. Gallium-doped cement for the treatment of bone cancers - The effect of ZnO« Ga2O3 substitution of an ionomeric glass series on the rheological, mechanical, pH and ion-eluting properties of their corresponding glass polyalkenoate cements, Sunjeev Phull, Alireza Yazdi, PhD, Mark Towler, PhD, Toronto Metropolitan University, Toronto, ON, Canada, Missouri University of Science and Technology, Rolla, MO, USA P1026

470. Optimization and Characterization of Pre-Osteoblast Seeded Bone Graft Materials, Kshetra Challapalli, Kadie Nobles, Courtney Cates, Sheetal Chowwdhury, Amol Janorkar, Randall Williamson University of Mississippi Medical Center, Jackson, MS, USA P1027

Bioinspired Approaches to Supramolecular Biomaterials

471. De novo design of short peptide hydrogelators as synthetic and viscoelastic organoid matrices, Ashley Nguyen, n/a, Thomas Molley, PhD, Sylvia Ganda, PhD, Kristopher Kilian, PhD, University of New South Wales, Sydney, Australia P1028

472. Extending the bioavailability of hydrophilic antioxidants for metal ion detoxification via crystallization with polysaccharide dopamine, Ryan Miller1, Youngsam Kim2, Chang Gyun Park2, Chris Torres1, Byoungsoo Kim, PhD3, Jonghwi Lee, PhD4, David Flaherty, PhD1, Hee-Sun Han, PhD1, Young Jun Kim, PhD2, Hyunjoon Kong, PhD1 1University of Illinois Urbana-Champaign, Urbana, IL, USA, 2KIST-Europe, Saarbrücken, Germany, 3Korean Institute of Ceramic Engineering and Technology, Jinju-si, Republic of Korea, 4Chung-Ang University, Seoul, Republic of Korea P1029

473. Designing Hybrid Hydrogels with Tunable Viscoelastic Properties, Abolfazl Salehi Moghaddam, Eugene Pashuck, PhD, Lehigh University, Bethlehem, PA, USA P1030

474. Three-Dimensional-Printed Multicomponent Biofilm-based Scaffolds, zahra abdali, Xinxin Hao, Dalia Jane Saldanha, Noemie-Manuelle Dorval Courchesne McGill University, Montreal, QC, Canada P1031

476. Assessment of a Novel Low-Cost Personal Respirator Evaluation Device, Quinton Burke, M.Eng., Kevin Aroom, M.S., P.E., Martha Wang, Ph.D., Robert E. Fishchell Institute for Biomedical Devices, University of Maryland, College Park, MD, USA P1033

Biomaterials for Cardiovascular Regeneration

477. An In Vitro Platform for Investigating Myocardial Therapeutic Angiogenesis, Rubia Shaik1, Jiazhu Xu2, Yong Wang3, Yi Hong2, Ge Zhang1,1The University of Akron, Akron, OH, USA, 2University of Texas at Arlington, Arlington, TX, USA, 3Penn State University, Pennsylvania, PA, USA P1034

478. Fabrication of electromechanical integrated cardiac patch for treatment of infracted myocardium, Xinlong Wang, Yugang Liu, Bin Jiang, Guillermo Ameer Northwestern University, Evanston, IL, USA P1035

479. Investigating Extracellular Vesicle Therapeutics in Cardiac Tissue-on-a-Chip Models of Ischemia-Reperfusion Injury, Karl Wagner, MEng1, Dawn Bannerman1, Rick Lu1, Milica Radisic1,2, 1University of Toronto, Toronto, ON, Canada, 2University Health Network, Toronto, ON, Canada P1036

480. Hydrogels with Tunable Stress Relaxation Rate and Stiffness Modulate Endothelial Cell Function, Mahdis Shayan, PhD1,2, Michelle Huang1, Renato Navarro1, Gladys Chiang2, Caroline Hu2, Beu Oropeza, PhD1,2, Patrik Johansson1, Sarah Heilshorn, Ngan Huang, PhD1,2,1Stanford University, Stanford, CA, USA, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA P1037

481. Adipose-Derived Stromal Cells Support the Endothelialization of an Electrospun Polyurethane Vascular Scaffold, Kate MacQuarrie, BASc1,2, Jeremy Antonyshyn, PhD1,2, Meghan McFadden, PhD1,2, Anthony Gramolini, PhD1,2, Stefan Hofer, MD, PhD1,3, Paul Santerre, PhD1,2,3,1University of Toronto, Toronto, ON, Canada, 2Ted Rogers Centre for Heart Research, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada P1038

482. Re-endothelialization and Anti-inflammation Using PLLA Composites Combined with Delivery System of Bioactive Agents, Dong Keun Han, Seung-Woon Baek, Chun Gwon Park, CHA Institute, Seonggyungwan University P1039

483. Novel liposomal JNK2 gene silencing platform for elastic matrix regenerative repair in Abdominal Aortic Aneurysms (AAAs), Shataakshi Dahal, PhD, Suraj Bastola, B.E., Anand Ramamurthi, PhD, Lehigh University, Bethlehem, PA, USA P1040

484. Cell-Encapsulating PEG Microbeads Support Prevascularization In Vitro and Angiogenic Sprouting In Vivo, Nicole Friend, MSE, Jan Stegemann, PhD, Andrew Putnam, PhD, University of Michigan, Ann Arbor, MI, USA P1041

485. Left and Right Ventricle Derived Myocardial Matrix Hydrogels Rescue Right Ventricular Function in a Model of Right Ventricular Heart Failure, Jervaughn Hunter1, Tanzeel Ahmed1, Arielle Hancko1, Michael Davis, PhD2, Karen Christman, PhD1, 1University of California San Diego, La Jolla, CA, USA, 2Georgia Institute of Technology and Emory University, Atlanta, GA, USA P1042

486. Cell-mediated matrix stiffening accompanies vascular morphogenesis in both natural and synthetic hydrogels, Atticus McCoy, BS, Nicole Friend, MSE, Irene Zhang, BS, Jan Stegemann, PhD, Andrew Putnam, PhD, University of Michigan, Ann Arbor, MI, USA P1043

487. Untethered Cardiac Stimulation and Pacing Based on Rubbery Optoelectronic Stimulators, Cunjiang Yu, Pennsylvania State University, University Park, PA, USA P1044

488. Microfabricated Anisotropic Myobundles Towards the Scaled Generation of 3D Cardiac Tissue, Maggie Jewett, Amanda Bluem, Susan Xi, Samuel DePalma, Brendon Baker, PhD, University of Michigan, Ann Arbor, MI, USA P1045

489. Ultra-Violet Crosslinked Decellularized Heart Matrix Allows for Surface Micropatterning and Cardiomyocyte Maturation In Vitro, Valinteshley Pierre, Chao Liu, Samuel Senyo, PhD, Case Western Reserve University, Cleveland, OH, USA P1046

490. Injectable ECM-based embolic delivering therapeutic agents for treating cerebral saccular aneurysms, Seungil Kim, PhD1, Kamil Nowicki, MD1, Kai Wang, PhD2, Sangho Ye, PhD1, William Wagner, PhD1, 1University of Pittsburgh, Pittsburgh, PA, USA, 2Harvard Medical School, Boston, MA, USA P1047

Biomaterials for Cultivated Meat

491. Edible Microcarriers For FAPs Proliferation And Differentiation, Rebeca Rivero, PhD, Ricardo Oliveira, Francesco Zaccarian, Anitha Kumar, PhD, Arin Doğan, PhD, Panagiota Moutsatsou, PhD, Mark Post, PhD, Mosa Meat, Maastricht, Netherlands P1048

492. A Comparative Study of Fetal Bovine Serum Alternatives for Muscle Tissue Engineering Applications, Gabriella White1,2, Irfan Tahir, MS1,3,4, Rachael Floreani, PhD1,1University of Vermont, Burlington, VT, USA, 2University of Vermont Food Systems Research Center, Burlington, VT, USA, 3New Harvest, Sacramento, CA, USA, 4University of Vermont Sustainable Campus Fund, Burlington, VT, USA P1049

493. 3D Nanofiber Scaffolds by Touch Spinning Method, Sergiy Minko, PhD1,2, Nataraja Yadavalli, PhD1,2, Brianna Blevins2, Vijay Mohakar2, Kristina Peranidze2, Anton Sorkin2, Vladimir Reukov2 1CytoNest, Inc., Athens, GA, USA, 2University of Georgia, Athens, GA, USA P1050

494. 3D-Printable Plant-Protein Enriched Scaffolds For Cultivated Meat Development, Iris Ianovici1, Yedidya Zaguri1, Idan Redenski1, Neta Lavon2, Shulamit Levenberg1,2, 1Technion - Israel Institute of Technology, Haifa, Israel, 2Aleph-Farms Ltd., Rehovot, Israel P1051

Biomaterials for Regenerative Engineering

495. Mussel-inspired bioadhesives with hemostatic and antimicrobial properties for wound healing, Saumya Jain, Avijit Baidya, Nasim Annabi, University of California, Los Angeles, Los Angeles, CA, USA P1052

496. Development of a Flexible Tissue Repair Patch Composed of Co-electrocompacted Chorion and Collagen for Treatment of Vesicovaginal, Fistula Ilaha Isali, MD, Phillip McClellan, Valinteshley Pierre, Thomas R. Wong, Sara Hijaz, Rachel Pope, Shubham Gupta, James M. Anderson, Ozan Akkus, Adonis Hijaz, Case Western Reserve University, Cleveland, OH, USA P1053

497. Reprogrammed Brown Adipose Tissue via Implantable Silicon Capsules as a Treatment Modality for Type II Diabetes, Devleena Das, MS1, Erin Goebel2, Neil Ott1, Silvia Duarte Sanmiguel3, Kavya Dathathreya1, Daniel Gallego Perez1,1The Ohio State University, Columbus, OH, USA, 2Texas A & M university, College Station, TX, USA, 3Andelyn biosciences, Columbus, OH, USA P1054

498. A woven scaffold fabricated from highly aligned electrospun yarn for skin tissue regeneration, Daxian Zha1, Martin King1, Jessica Gluck1, Ashley Brown1, James Petitte1, Robert Kellar,1North Carolina State University, Raleigh, NC, USA P1055

499. Effect of Ellagic acid and retinoic acid on collagen and Elastin production by Human Dermal Fibroblasts, Nasim, Mosoudi, Chloe Duckworth, Jada Stutts, Kayla Clatterbuck, Department of biomedical engineering, College of Engineering and Computer Sciences (CECS), Marshall University P1056

500. Development of Oxygen-Generating Scaffolds Supporting Cell Proliferation Under Hypoxia, Robin Augustine, PhD1, Gulden Camci-Unal, PhD1,2, 1University of Massachusetts, Lowell, MA, USA, 2University of Massachusetts Medical School, Worcester, MA, USA P1057

504. Eggshell Particle-Reinforced Biomaterials for Bone Regeneration, Mert Gezek1, Xinchen Wu, PhD1, Gulden Camci-Unal1,2
1University of Massachusetts Lowell, Lowell, MA, USA, 2University of Massachusetts Medical School, Worcester, MA, USA P1061

505. Does the hydrogel stiffness modulate in vivo vascularization? Fan Zhang, PhD, Colleen O’Connor, PhD, Susana Simmonds, Kelly Stevens, PhD, University of Washington, Seattle, WA, USA P1062

506. Modulating Pentenoate-Functionalized Hyaluronic Acid Hydrogel Network Formation for Meniscal Fibrochondrocyte Mechanotransduction, Kyley Burkey, Kayla Castillo, Philip Elrod, Murilo Suekuni, Elizabeth Aikman, Stevin Gehrke, PhD, Alan Allgeier, PhD, Jennifer Robinson, PhD, University of Kansas, Lawrence, KS, USA P1063

507. Watt's the buzz? Electrically Active Hernia Repair Mesh Cellular Viability Study, Victoria Drapal, MS1, Savannah Mosier2, Lisa Friis, PhD3, Jennifer Robinson, PhD4, 1University of Kansas - Bioengineering Program, Lawrence, KS, USA, 2University of Kansas - Bioengineering, Lawrence, KS, USA, 3University of Kansas - Mechanical Engineering, Lawrence, KS, USA, 4University of Kansas - Chemical and Petroleum Engineering, Lawrence, KS, USA P1064

508. 3D Printed Porous Scaffolds Infused with a Bioresorbable Mineral-Organic Bone Adhesive, Alina Kirillova, PhD1, Ken Gall, PhD2, 1Iowa State University, Ames, IA, USA, 2Duke University, Durham, NC, USA P1065

509. Nanoparticle Loaded Granular Scaffolds for Local Gene Delivery to Enhance Wound Repair, Evan Kurt, M.S., Tatiana Segura, Ph.D.
Duke University, Durham, NC, USA P1066

510. Gene delivery via reactive polymer coating for enhanced cell communication, Merjem Mededovic, David Kohn, PhD, Joerg Lahann, PhD, Xiaoyang Zhong, University of Michigan, Ann Arbor, MI, USA P1067

511.3D Printed Synergistic Graphene Citrate Composite Scaffolds for Craniofacial Bone Reconstruction, Mirae Kim1, Caralyn Collins1, Tong-Chuan He2,3, Cheng Sun1, Guillermo Ameer1, Russell Reid2, 1Northwestern University, Evanston, IL, USA, 2The University of Chicago Medical Center, Chicago, IL, USA, 3The Affiliated Hospitals of Chongqing Medical University, Chongqing, China P1068

512. ECM Gel Injection Enhances Recovery from Both Disuse and Degenerative Muscle Atrophy, Chris Slavin1, Tai Hyun1, Jeffrey Wolchok1, Shahryar Ahmadi2, 1University of Arkansas, Fayetteville, AR, USA, 2University of Arkansas for Medical Sciences, Little Rock, AR, USA P1069

513. Bioprinted Wound Mesh for Pressure Ulcers, Sandra Zori, PharmD, Julie Zwiesler-Vollick, PhD, Yawen Li, PhD, Lawrence Technological University, Southfield, MI, USA P1070

514. Anisotropic Decellularized Skeletal Muscle Extracellular Matrix, Yong How Tan, Owen Lally, Karina Nakayama, Oregon Health & Science University, Portland, OR, USA P1071

515. The newly discovered chemokine-mimicking peptide-loaded cross-linked hyaluronan scaffold to accelerate wound healing through endogenous mesenchymal stem cell recruitment, Young Hun Kim, Moon Suk Kim, Ajou univ., Suwon, Republic of Korea P1072

516. Osteogenic potential of the construct composite with adipose tissue-derived mesenchymal stem cells (ADSCs), bone substitutes and platelet rich fibrin (PRF), Rodrigo Oliveira1, Bruna Costa1, Adrano Pêssoa1, Cintia Tokuhara1, Mariana Sanches1, Ana Bighetti1, Tânia Cestari1, Paulo Lisboa-Filho2, 1Bauru School of Dentistry, University of São Paulo, Bauru, Brazil, 2School of Sciences, São Paulo State University, Bauru, Brazil P1073

517. Engineered Asymmetric Hydrogel for Controlling Muscle Stem Cell Proliferation and Expansion, GaYoung Park, Woojin Han, Icahn School of Medicine at Mount Sinai, New York, NY, USA P1074

518. Protein Release by Controlled Desorption from Transiently Cationic Nanoparticles, Timothy Cheung, Chang Xue, Daniel Kurtz, Molly Shoichet, University of Toronto, Toronto, ON, Canada P1075

519. The Effect of Bi-modal Structure on Curcumin Release from Electrospun Gelatin/PCL Scaffolds, Ali Sadeghianmaryan, PhD1, Joel Bumgardner, PhD1, Hamed Alizadeh Sardroud2, Alex Bryan1, Azadeh Asefnejad, PhD3,1University of Memphis, Memphis, TN, USA, 2University of Saskatchewan, Saskatoon, SK, Canada, 3Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran P1076

520. Injectable and Immunomodulatory Hydrogels for Promoting Axonal Regeneration in Injured Spinal Cord, Gopal Agarwal, Ph.D., Allison Campbell, Arun Wanchoo, Jacob Fuhr, Olivia Osborne, Benjamin Keselowsky, Ph.D., Christine Schmidt, Ph.D. University of Florida, Gainesville, FL, USA P1077

521. Evaluating a Novel Cell Source for Bladder Tissue Engineering, Matthew Bury1, Arun Sharma, PhD1,2,3, Guillermo Ameer, PhD2,3, Madeleine Goedegebuure, BS2, 1Lurie Children's Hospital, Chicago, IL, USA, 2Northwestern University, Evanston, IL, USA, 3Feinberg School of Medicine, Chicago, IL, USA P1078

522. Evaluation of glutaraldehyde crosslinked electrospun chitosan membranes modified with gelatin and elastin for skin wound healing, Ethan Wales1, Alex Bryan1, Ali Sadeghianmaryan, PhD1, Andreu Blanquer, PhD2, Lucie Bačáková, PhD2, Joel Bumgardner, PhD1,1University of Memphis, Memphis, TN, USA, 2Czech Academy of Sciences, Prague, Czech Republic P1079

523. A Self-Healing Hyaluronic Acid-Poly(Vinyl Alcohol Citrate) Hydrogel for Spinal Cord Injury Treatment, Mark Pitman, Jessica Larsen, PhD, Clemson University, Clemson, SC, USA P1080

524. A Modified Chitosan-Polyethylene Glycol Bio-ink for use in Additive Manufacturing, Andrew Watson, MS1, Julia Strecker, BS1, Joel Bumgardner, PhD2, Tomoko Fujiwara, PhD2, 1University of Memphis Student, Memphis, TN, USA, 2University of Memphis Academia, Memphis, TN, USA P1081

525. Panthenol citrate-based biomaterials accelerate diabetic wound closure and promote tissue regeneration, Huifeng Wang, PhD, Chongwen Duan, Guillermo Ameer, ScD, Northwestern University, Evanston, IL, USA P1082

526. Multi-Structured Scaffold for Myotendinous Junction Regeneration, Elizabeth Aikman, Marisa Pacheco, Whitney Stoppel, PhD, Brittany Taylor, PhD, Kariman Shama, University of Florida, Gainesville, FL, USA P1083

527. Differentiation of hMSCs on Mineralized Silk Nanofibers for Enthesis Repair, Gabrielle Hamner, Justin Brown, PhD, The Pennsylvania State University, State College, PA, USA P1084

528. Hybrid double network cryogels scaffold for repair of focal cartilage defect, Kaixiang Zhang1,2, Michael Seitz1,2, Zining Yang1,2, Era Jain1,2, 1Department of Biomedical& Chemical Engineering,Syracuse University, Syracuse, NY, USA, 2Bioinspired Institute, Syracuse University, Syracuse, NY, USA P1085

529. Injectable and Biodegradable Hybrid Double-network Cryogels Scaffold for Cartilage Regeneration, Zining Yang1,2, Kaixiang Zhang1,2, Michael Seitz1,2, Era Jain, PhD1,2,1Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, NY, USA, 2Bioinspired institute, Syracuse University, Syracuse, NY, USA P1086

530. Evaluating the Osteoinductivity of Different Biomaterials used for Bone Regeneration, Andrea Vera Martinez1, Jeremy Mercuri, PhD1, Anna Reza, PhD2, 1Clemson University, Clemson, SC, USA, 2Stryker Spine Division, Allendale, NJ, USA P1087

531. Isolating Dural Stem Cells for Mechanical Stimulation with Ultrasound, Hanna Anderson1, Kevin Grassie1, David Hersh, MD2, Yusuf Khan, PhD3, 1University of Connecticut, Storrs, CT, USA, 2Connecticut Childrens Hospital, Hartford, CT, USA, 3UCONN Health, Farmington, CT, USA P1088

532. ECM based hydrogel delivery vehicles and 3D in vitro injection model for human retinal progenitor cells transplantation, Peng Zhao1, Rebecca Carrier1, Sidi Bencherif1, Michael Young2, 1Northeastern University, Boston, MA, USA, 2Schepens Eye Research Institute, Boston, MA, USA P1089

533. Threat of Biocompatibility due to Allogeneic Cells in Tissue Regenerative Matrices, Subramanian Gunasekaran, PhD, Encoll Corp., Fremont, CA, USA P1090

535. Evaluating the Osteostimulatory Properties of OssiMend® Bioactive Moldable, a Bone Graft Substitute for Spine and Orthopedic Use, Diana Legarda, PhD, Spencer Fink, Hui-Chen Chen, PhD, Daniel Ammon, PhD Collagen Matrix, Inc., Oakland, NJ, USA P1092

536. A Potential Extracellular Matrix-Based Scaffold for Cartilage Regeneration, Vishal Thomas, MS, Jeremy Mercuri, PhD, Clemson University, Clemson, SC, USA P1093

537. Development of a Multifunctional Hydrogel Platform for Investigating and Enhancing Muscle Regeneration, Alycia Galindo, BS, Veronica Spaulding, Esther Mozipo, Kelly O'Neill, Ievgenii Liashenko, PhD, Chandler Asnes, Madeleline Ford, Paul Dalton, PhD, Marian Hettiaratchi, PhD, University of Oregon Phil and Penny Knight Campus for Accelerating Scientific Impact, Eugene, OR, USA P1094

538. Development of a Pre-Crosslinked Decellularized Extracellular-Based Scaffold for Nucleus Pulposus Replacement, Christopher Theos, Jeremy Mercuri, PhD, Clemson University, Clemson, SC, USA P1095

539. Engineering Large Anisotropic Meniscal Microtissues via Digital Light Processing Printed Molds, Alysse DeFoe1,2, Abhishek Dhand2,3, Matthew Davidson, PhD1,2, Mackenzie Obenreder1,2, Jason Burdick, PhD1,2, 1University of Colorado Boulder, Boulder, CO, USA, 2BioFrontiers Institute, Boulder, CO, USA, 3University of Pennsylvania, Philadelphia, PA, USA P1096

Biomaterials in Engineering the Tumor Immune Microenvironment

540. Mineral-Coated Iron Oxide Microparticles Promote M1 Macrophage Polarization, Hannah Martin, Iris Baurceanu, William Murphy, PhD, Portia Smith, University of Wisconsin- Madison, Madison, WI, USA P1097

541. Shear-thinning Hydrogel for the Delivery of Combined Chemo- and Immunotherapies for the treatment of Hepatocellular Carcinoma, Natashya Falcone, Menekse Ermis, Natan Barros, Vadim Jucaud, HanJun Kim, Ali Khademhosseini, Auveen Choroomi, Patric Young, Terasaki Institute for Biomedical Innovation, Westwood, CA, USA P1098

542. Exploring lymphangiogenic function of microglia in brain microphyisiological models in vitro, Chia-Wen Chang, PhD, Brendan Harley, PhD, University of Illinois Urbana-Champaign, Urbana, IL, USA P1099

Biomaterials Systems and Devices for Hemostasis and Wound Care

543. Studies of polymeric quaternary ammonium salts with biomimetic catechol terminal end: synthesis and its application for surface modification of various biomaterials, Chi-Hui Cheng, PhD, MD1, Xiang-Zhen Zeng2, Wen-Yuan Chiu2, Jui-Che Lin, PhD2,1Chang Gung University, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan, 2National Cheng Kung University, Tainan, Taiwan P1100

544. Effects of Pore Structure on Coagulation in Shape Memory Polymer Foam Hemostatic Dressings, Natalie Petryk, MS, Grace Haas, Anand Vakil, PhD, Mary Beth Monroe, PhD Syracuse University, Syracuse, NY, USA P1101

545. A Hydrogel Foam Dressing with Self-Tuning Moisture Balance to Improve Chronic Wound Healing, Ziyang Lan1, Ronit Kar1, Malgorzata Chwatko, PhD2, Erik Shoga1, Elizabeth Cosgriff-Hernandez, PhD1 1The University of Texas at Austin, Austin, TX, USA, 2University of Kentucky, Lexington, KY, USA P1102

546. Profiling the Cellular Uptake of Nucleic Acids Locally Released in Wounds from Self-assembled Dressings Adam Berger1, Chau Vo1, Elad Deiss-Yehiely1, Mark Feinberg, MD2, Paula Hammond, PhD1 1Massachusetts Institute of Technology, Cambridge, MA, USA, 2Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA P1103

547. A Neat Approach to Developing Tissue Adhesives, Boaz Mizrahi1, Neta Shimony1, Alona Shagan1, Dan Kohane2 1Technion, Israel Institute of Technology, Haifa, Israel, 2Harvard, Boston, MA, USA P1104

548. Human Hair Bio-Waste Extracted Keratin and Alginate Dual Crosslinked Micro-fibers for Haemostatic Application. Ashmita Mukherjee1, Shivangi Parhi1, Paulomi Ghosh2 1CSIR-Indian Institute of Chemical Biology (CSIR-IICB), KOLKATA, India, 2Presidency University, KOLKATA, India P1105

549. Rapid action polymer-based sponges for in situ hemostatic treatment, Pritha Sarkar, Kausik Mukhopadhyay, PhD University of Central Florida, Orlando, FL, USA P1106

550. Antimicrobial Peptide Functionalized Bacterial Cellulose for Wound Dressing Applications, Jeannine Coburn, PhD, Elizabeth van Zyl
Worcester Polytechnic Institute, Worcester, MA, USA P1107

551. Modular Stabilization of Whole Blood Components for Reconstitution and Transfusion at the Point of Injury, Lauren Costella, ME1, Kate Johnson1, Kelsey Broderick1, William Velander, PhD2, Martin Mangino, PhD3 1Luna Labs USA LLC, Charlottesville, VA, USA, 2University of Nebraska - Lincoln, Lincoln, NE, USA, 3Virginia Commonwealth University, Richmond, VA, USA P1108

552. Layer-by-Layer Functionalized Gauze for Synthetic Anti-Biofilm Peptide Releasing Wound Dressings, Sarah Nick, James Bryers, PhD, Valerie Daggett, PhD, University of Washington, Seattle, WA, USA P1109

553. Neonatal Fibrin Based Nanoparticles for Wound Healing, Sanika Pandit, Kimberly Nellenbach, Nina Moiseiwitsch, Ashley Brown
NC State University/UNC-Chapel Hill, Raleigh, NC, USA P1110

555. Efficacy of Knitted Biotextile Substrates for Conductive Nanocomposite Sensors for Diabetic Chronic Wound Healing Cyndel Streeter, Shreya Thammana, Stephanie Jeziorski, Craig Miller, PhD, Jordon Gilmore, PhD Clemson University, Clemson, SC, USA P1112

556. Keratin-Biphalin Dressing Accelerates Skin Wound Healing in Diabetic Mice Through Activation of AKT-mTOR Pathway, Marek Konop, PhD, Łukasz Mazurek, Mateusz Rybka, MD, Mateusz Szudzik, PhD, Anna Laskowska, PhD, Joanna Czuwara, MD, PhD, Marcin Ufnal, MD, PhD, Medical Univeristy of Warsaw, Warsaw, Poland P1113

557. Keratin-trimethylamine-N-oxide Dressing Accelerates Skin Wound Healing in Diabetic Rats, Łukasz Mazurek1, Mateusz Rybka, MD1, Mateusz Szudzik, PhD1, Joanna Czuwara, MD, PhD1, Dorota Sulejczak, PhD2, Marcin Ufnal, MD, PhD1, Marek Konop, PhD1
1Medical University of Warsaw, Warsaw, Poland, 2Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland P1114

Biomaterials to Engineer Tissue Morphodynamics

558. Effects of Varying Pitch Angle on Stress Response of an Algorithmically Designed 3D Printed Bone Scaffold, Jake Millburn, Christian Buckley, Sally Shady, PhD, Stevens Institute of Technology, Hoboken, NJ, USA P1115

Biomaterial-Tissue Interaction (SIG)

559. Novel Drug Delivery System to Reduce Fibrous Encapsulation in Glaucoma Drainage Devices, Maximilian Zernic1, Ozan Akkus, PhD1, Maryo Kohen, MD2, Faruk Orge, MD2,1Case Western Reserve University, Cleveland, OH, USA, 2University Hospitals, Cleveland, OH, USA P1116

560. Spatio-temporal Photothermal and Chemotherapy Using Injectable Composite Hydrogel Embedding Eutectic Ga/In Liquid Metal Particle against Triple Negative Breast Cancer, Wonjeong Lee1, Min Joo Shin2, Jae Ho Kim2, Kyobum Kim1,1Dongguk University, Seoul, Republic of Korea, 2Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea P1117

561. Cell migration and growth within electrospun nanofiber sheets with defined pore sizes in a mouse pouch model, David Markel, MD.1,2, Therese Bou-Akl, MD., PhD.1,2, Paula Dietz, MS.1, Bin Wu, MD.1, Weiping Ren, MD., PhD.1,2,3,1Ascension Providence Hospital, Southfield, MI, USA, 2Wayne State University, Detroit, MI, USA, 3Virotech Co., Westland, MI, USA P1118

562. Identifying Peptides with Cell-Specific Degradation, Katherine Atherton, Eugene Pashuck, PhD, Lehigh University, Bethlehem, PA, USA P1119

563 Elucidating Macrophage Persistence in the Immune Response to Implanted Biomaterials, Joshita Suresh, BChE1, Alexandra McCubbrey, PhD2, William Janssen, MD2, Scott Alper, PhD2, Stephanie Bryant, PhD1,1University of Colorado Boulder, Boulder, CO, USA, 2National Jewish Health, Denver, CO, USA P1120

564. Observation of Microgel Poroelastic Deformation via Nanopore Translocation, Andrew Lyon, PhD, Elif Narbay, Anne Marie Santich, Chapman University, Orange, CA, USA P1121

565. Thermogelling Hydrogel Charge and LCST Influence Cellular Infiltration and Tissue Integration in an Ex Vivo Cartilage Explant Model, Hannah Pearce, Rice University P1122

Bioprinting Vascularized Tissue Constructs

566. High Cell Density and High Resolution 3D bioprinting of Vasuclarized Tissue, Yi Xiang, Shangting You, PhD, David Berry, PhD, Shaochen Chen, PhD, University of California San Diego, La Jolla, CA, USA P1123

567. 3D BIOPRINTING FOR THE PRODUCTION OF A PERFUSABLE VASCULARIZED MODEL OF A CANCER NICHE, Federico Maggiotto, PhD1,2, Camilla Pozzer1,2, Elisa Cimetta1,2,1Università degli Studi di Padova, Padova, Italy, 2Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy P1124

569. Adding PLGA Nanoparticles to HAMA-GelMA Hydrogels to Bioprint In Vitro Blood-Brain Barrier Models, Kristie Cheng1, Noah Pyles1, Rana Ajeeb2, John Clegg, PhD2, Cody Crosby, PhD1,3, 1Southwestern University, Georgetown, TX, USA, 2University of Oklahoma, Norman, OK, USA, 3The University of Texas at Austin, Austin, TX, USA P1126

570. Large-scale tissue fabrication and micro-scale 3D cell migration, Qi Gu, Beijing Institute for Stem Cell and Regenerative Medicine, Institute of Zoology, Chinese Academy of Sciences P1127

571.Template-Based Formation of Interconnected, Perfusable Channel Networks for Bone Tissue Regeneration, Christian Buckley, Hongjun Wang, Stevens Institute of Technology, Hoboken, NJ, USA P1128

572. Gelatin Norbornene-Based Bioink for Vascularized Tissue Fabrication Using Digital Light Processing 3D Bioprinting, Van Thuy Duong, PhD, Chien-Chi Lin, PhD, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA P1129

Dental/Craniofacial Biomaterials (SIG)

573. In Vitro Engineering of a 3D Pulp tissue Model for in-Lab Assessment of Dental Biomaterials, Fahimeh Tabatabaei, PhD, iFyber, Ithaca, NY, USA P1130

574. High-Temperature 3D Printing of Patient-Specific Polyetheretherketone (PEEK)-based Restorative Orthopedic Devices, Surendrasingh Sonaye, Vijay Bokam, Prabaha Sikder, Cleveland State University, Cleveland, OH, USA P1131

575. Doxycycline loaded thiol-ene microparticles for periodontal disease treatment, Chipo Chapusha, Nicholas McGowan, Paige Smith, Mary Carr, Mary Marquart, Amol Janorkar University of Mississippi Medical Center, Jackson, MS, USA P1132

576. Branched Channels in β-Tricalcium Phosphate (β-TCP) Scaffolds Promote Vascularization, Yunqing Kang Florida Atlantic University, Boca Raton, FL, USA P1133

577. Cell Accelerated Corrosion: The Impact of Human Gingival Fibroblasts on Dental Implant Corrosion, Mostafa Alhamad1,2, Yinghua Chen1, Anne George1, Valentim Barao3, Cortino Sukotjo1, Mathew Mathew1, 1University of Illinois at Chicago College of Dentistry, Chicago, IL, USA, 2Imam Abdulrahman Bin Faisal University College of Dentistry, Dammam, Saudi Arabia, 3University of Campinas Piracicaba Dental School, Piracicaba, Brazil P1134

578. 3D Printed Patient-Specific Bone Graft Composite For Improved Cell Infiltration and FGF Release, Claudia Benito Alston, BS1, Madelyn Chadwick1, Saaniya Rupani1, Marina Murphy1, Nicanor Moldovan, PhD, MS2, Clark Barco, DDS2, Luis Solorio, MS, PhD1, 1Purdue University, West Lafayette, IN, USA, 2Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA P1135

579. Surface Chemistry Analysis of Commonly Used Titanium Surfaces Under Controlled Conditions Minkyung Jeon, DDS, John Ricci, PhD, Bill Maas, Navid Kerayehchian, Dindo Mijares, DDS, New York University College of Dentistry, New York, NY, USA P1136

580. Impact of Dental Cement on Peri-implant Disease Development: A Preclinical Study in Lewis Rats, Bhuvana Lakkasetter Chandrashekar, M.S.1, Claudia Biguetti, PhD, M.S., DDS2, Alexandra Arteaga, M.S.1, Andres Miramontes1, Evelin Rios1, Danieli Rodrigues, PhD1, 1University of Texas Rio Grande Valley, Edinburg, TX, USA, 2The University of Texas at Dallas, Richardson, TX, USA P1137

581. Electrospun Chitosan Membranes Dually Loaded with Raspberry Ketone and Simvastatin to Determine Drug Release for Guided Bone Regeneration Haley Pruitt, Joel Bumgardner, University of Memphis, Memphis, TN, USA P1138

582. Zinc-doped fluoridated apatite as an engineered bone filler for craniofacial bone regeneration, Samantha Steyl1,2, Alec Griffin, DDS2, Clark Nielson1,2, Jill Shea, PhD1,2, Peter Beck, MD1,2, Jay Agarwal, MD1,2, Sujee Jeyapalina, PhD1,2, 1University of Utah, Salt Lake City, UT, USA, 2Salt Lake City Veterans Affairs, Salt Lake City, UT, USA P1139

583. Bioactive Grafts, Growth Enhancers and Barriers In Dental and Craniofacial Surgery, Robert Horowitz, DDS, NYU College of Dentistry, NY, NY, USA P1140

584. Growth factors and enhancers for Dental, Periodontal and Oral Surgical Regeneration of Hard Tissue, Robert Horowitz, DDS, NYU College of Dentistry, NY, NY, USA P1141

585. Effect of Pre-and Post-irradiation Silver Diamine Fluoride Treatment on the Hardness of Dentin, Rachel Kulchar1, Florin Eggmann2, Celine Mina2, Steven Szewczyk3, Kakiuchi Yusuke4, Jie Deng5, Francis Mante2, 1Princeton University, Princeton, NJ, USA, 2University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA, 3University of Pennsylvania School of Engineering and Applied Science, Philadelphia, PA, USA, 4Sweden Dental Center Sendai, Miyagi, Japan, 5University of Pennsylvania School of Nursing, Philadelphia, PA, USA P1142

586. Stabilised Calcium Phosphate for Encapsulation in PLGA Particles, Hamish Poli, BSc(Hons 1), Anitha A, PhD, MTech, MSc, Lisbeth Grøndahl, PhD, mRACI, FSBE, The University of Queensland, St Lucia, Australia P1143

587 Titanium anodization processes to create multifunctional oxide surfaces, Amisha Parekh, BDS, Parker Odom, Amol Janorkar, PhD, Michael Roach, PhD, University of Mississippi Medical Center, Jackson, MS, USA P1144

588. Innovative Nanoparticle Scaffold for Enhanced Bone Regeneration in Craniomaxillofacial Tissues, Karrer Alghazali1, Srinivas Myneni2, Steve Trigwell1, Malathi Srivatsan1, David Lam2,3, Alexandru Biris1,4, 1NuShores Biosciences LLC, Little Rock, AR, USA, 2Stony Brook University, Stony Brook, NY, USA, 3University of Pacific, Stockton, CA, USA, 4University of Arkansas at Little Rock, Little Rock, AR, USA P1145

Development of Novel Bioinks for Tissue Engineering

589. Self-standing alginate-hyaluronate hydrogel for 3D bioprinting-based tissue engineering, Insup NOH, Gopinathan Janarthanan, Ph.D., Jung Hyun Kim, Amitava Bhattacharyya, Seoul National University of Science and Technology, Seoul, Republic of Korea P1146

Devices Designed for Imaging

591. Ultra-Thin PDMS Microgrids for Two-Photon and AFM alignment, Adam Baker, Bruce Gao, PhD, Katherine Powers, Clemson University, Clemson, SC, USA P1148

592. Contrast-Enhanced Detection and Quantitative Molecular Imaging of Breast Microcalcifications with Spectral Photon-Counting Computed Tomography Connor Evans, Tyler Finamore, PhD, Ryan Roeder, PhD, University of Notre Dame, Notre Dame, IN, USA P1149

Engineered Biomaterials for Neural Applications

593. The Effects of Varying Levels of Fibrin on Human Astrocyte Behavior using 3D Engineered Scaffolds, Meagan McKee, Swathisri Ravi, Andrea Jimenez-Vergara, PhD, Dany Munoz-Pinto, PhD, Trinity University, San Antonio, TX, USA P1150

594. Polysaccharide-Based Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins Carolyn Jons, Eric Appel, PhD, Stanford University, Stanford, CA, USA P1151

595. Direct Laser Writing of Multi-Material Microelectrodes for Potential Neural Recording and Stimulation. Omid Dadras-Toussi, Mohammad Reza Abidian, PhD, University of Houston, Houston, TX, USA P1152

596. Altering the Gut Microbiome Influences Intracortical Microelectrode Performance and Brain Bacteria Levels George Hoeferlin1,2, Jonathan Duncan1,2, Jichu Zhang1,2, Alice Lee1,2, Christopher Hong1,2, Grace Burkhart1, Jennifer Cadnum2, George Jaskiw, PhD1,2, Curtis Donskey, PhD1,2, Joseph Pancrazio, PhD3, Horst Von Recum, PhD1, Jeffrey Capadona, PhD1,2 1Case Western Reserve University, Cleveland, OH, USA, 2Louis Stokes Cleveland Veteran Affairs Medical Center, Cleveland, OH, USA, 3The University of Texas at Dallas, Richardson, TX, USA P1153

597. Direct Laser Writing of Multi-Material Microelectrodes for Potential Neural Recording and Stimulation Omid Toussi, Mohammad Abidan, University of Houston P1154

598. Gold Nanostars as Brain-Machine Interfaces for Photothermal Neuromodulation Saman Ebrahimibasabi, PhD, Hamed Arami
Arizona State University, Tempe, AZ, USA P1155

599. 3D In Vitro Model for Human Microglia-mediated Inflammatory Responses to Amyloid Beta Species, Noah Fulcomer1, Andrea Jimenez-Vergara, PhD1, George Perry, PhD2, Germán Plascencia-Villa, PhD2, Dany Munoz Pinto, PhD1, 1Trinity University, San Antonio, TX, USA, 2University of Texas at San Antonio, San Antonio, TX, USA P1156

600. Electrical Stimulation of Human Schwann Cells for Disease Models Judy Senanakeay, Harini Sundararaghavan, PhD, Wayne State University P1157

601. Expanding the Application of Drug-Eluting Reservoirs in the Brain Christopher Moody, PhD1,2, Phillip Durham, PhD2, Yevgeny Brudno, PhD1,2, Paul Dayton, PhD1,2, 1North Carolina State University, Raleigh, NC, USA, 2University of North Carolina - Chapel Hill, Chapel Hill, NC, USA P1158

602. Mechanically-Adaptive, Resveratrol-Loaded Intracortical Microelectrodes for Neural Interfacing Natalie Mueller1,2, Youjoung Kim1,2, Mali Ya Mungu Ocoko1,2, Anna Clarissa Hermoso1,2, Peter Dernelle1,2, Deeksha Chirra1,2, Jeffrey Capadona, PhD1,2, Allison Hess-Dunning, PhD1,2, 1Case Western Reserve University, Cleveland, OH, USA, 2Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA P1159

603. Investigating the Potential of Aligned Peripheral Nerve Scaffolds In Vitro, Mackenzie Lewis, Gabriel David, Patrick Kuczwara, Jin-Woo Kim, PhD, Young Hye Song, PhD, University of Arkansas, Fayetteville, AR, USA P1160

604. Decellularized Porcine Sciatic Nerve Based Hydrogel for Tissue Regeneration: Challenges and Opportunities Gopal Agarwal, Ph.D., Olivia Osborne, Michaela McCrary, Ph.D., Jorge Alexis Mojica Santiago, Ph.D., Breanna Ausec, Christine Schmidt, Ph.D. University of Florida, Gainesville, FL, USA P1161

605. Sustained Release of Biologically Active Neurotrophin-3 from Hyaluronic Acid Hydrogels Pablo Ramos Ferrer, Shelly Sakiyama-Elbert
University of Washington, Seattle, WA, USA P1162

606. Nanomaterials for immunotherapy against multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) Alireza Hassani Najafabadi1, Neda Mohaghegh1, James Moon2, Ali Khademhosseini1, 1Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA, 2University of Michigan, Ann Arbor, MI, USA P1163

607. Characterization of a Low-Cost, Open-Source Nanoprecipitation Method for Fabrication of Polyester Nanoparticles, Dhrasti Dalal, David Flores-Prieto, MSc., Sarah Stabenfeldt, PhD Arizona State University, Tempe, AZ, USA P1164

608. Dose-Dependent Cytotoxicity of IV Chemotherapeutics to Cellular Components of the Blood-Brain-Barrier Trinity Hoff1, John Clegg, PhD, 1University of Oklahoma, Norman, OK, USA P1165

Engineered Recombinant Protein-Based Scaffolds for Tissue Engineering

609. Bioinks based on recombinant collagenoid protein for 3D bioprinting Yunxiao Liu, Eva Loo, Cell and Tissue Engineering, Evonik Asia Research Hub, Singapore, Singapore P1166

610. An On-Demand Photodegradable Recombinant Protein Hydrogel for Injectable Cell Delivery Nicole Gregorio, Cole DeForest, PhD
University of Washington, Seattle, WA, USA P1167

611. Bioprinting of a Novel Hydrogel Derived from Hagfish Keratin Proteins Yu Huang, Justin Jones, Cheng Chen, Ethan Edwards, Bailey McFarland, Utah State University P1168

Extracellular Vesicles for Biomedical Applications

612. Investigation of Urinary Extracellular Vesicles (uEVs) for ADPKD Therapy Yi Huang, Eun Ji Chung, University of Southern California, Los Angeles, CA, USA P1169

613. Natural Killer Cell-Derived Extracellular Vesicles as Potential Anti-Viral Nanomaterials Siyoung Lim, BA, University of Southern California, Los Angeles, CA, USA P1170

614. Engineering Vascular Smooth Muscle Cell Extracellular Vesicles as Theranostic Agents for Vascular Calcification Neil Patel, Eunji Chung, University of Southern California P1171

615. Supramolecular hydrogel loaded with small extracellular vesicles derived from magnesium ions-stimulated bone marrow stromal cells facilitate osteochondral defect regeneration Liang Chang, Jiaxin Guo, Wenxue Tong, Ling Qin, Jiankun XuThe Chinese University of Hong Kong, Hong Kong, Hong Kong P1172

616. DNA Tags to Study Red Blood Cells-Derived Extracellular Vesicles Uptake and Biodistribution Oscar Boyadjian, MSc, Stéphanie Lehoux, PhD, Maryam Tabrizian, PhD, McGill University, Montreal, QC, Canada P1173

617. Exosomes as donor of sphingosine-1 phosphate to promote a microenvironment for metastatic lung cancer Jung-Hee Kim, Eun-Sook Choi, Kyeong-Min Lee, Yeo Jin Hwang, Eunjoo Kim, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea P1174

618. The neural regeneration effect of matrix bound nanovesicles derived from high hydrostatic pressure decellularized tissues. Mako Kobayashi, PhD1, Jun Negishi, PhD2, Naoki Ishida3, Yoshihide Hashimoto, PhD3, Masaya Yamamoto, PhD1, Yoshihiro Sasaki, PhD4, Kazunari Akiyoshi, PhD4, Tsuyoshi Kimura, PhD3, Akio Kishida, PhD3, 1Tohoku University, Sendai, Japan, 2Shinshu University, Ueda, Japan, 3Tokyo Medical and Dental University, Tokyo, Japan, 4Kyoto University, Kyoto, Japan P1175

Nature Bioinspired Biomaterials and Strategies for TERM

619. Chitosan/Polyvinyl Alcohol Methacrylate Hydrogels for Tissue Engineering Scaffolds Nghia Thai, MD, Henry Beaman, PhD, Megan Perlman, Mary Beth Monroe, PhD, Syracuse University, Syracuse, NY, USA P1176

620. On-Demand Activation of Protein Wrinkled Coatings for Biomedical Applications Elizabeth Oguntade1, James Henderson1, Helen Zha2, 1Syracuse University, Syracuse, NY, USA, 2Rensselaer Polytechnic Institute, Troy, NY, USA P1177

622. Sweet Corn Phytoglycogen as a Protein Stabilizing Excipient Junha Park, Renjie Liu, PhD, Marcio Resende, PhD, Susan Boehlein, PhD, ‪Gregory Hudalla, PhD, University of Florida, Gainesville, FL, USA P1179

623. Tuning the Topography of Dynamic, 3D Scaffolds through Wrinkled Protein Coatings Elizabeth Oguntade1, Helen Zha2, James Henderson1, 1Syracuse University, Syracuse, NY, USA, 2Rensselaer Polytechnic Institute, Troy, NY, USA P1180

Ophthalmic Biomaterials (SIG)

624. Lens epithelial cell response to polymer mechanical properties and micropatterns Hamid Hamedi, PhD, Raima Puri, Jian Liu, BS, Hanna Cho, PhD, Derek Hansford, PhD, Heather Chandler, PhD, Katelyn Swindle-Reilly, PhD, The Ohio State University, Columbus, OH, USA P1181

625. Living Probiotics Biofilm Contact Lenses Coating for Drug-resistant Bacterial Keratitis Therapy miao Xu, Ho Cheung Shum, The University of Hong Kong, Hong Kong, Hong Kong P1182

626. Bio-Orthogonally Crosslinked, In Situ-Forming Collagen-Hyaluronan Hydrogel Promotes Corneal Stromal Restoration: 2-Month Response in vivo Fang Chen, PhD1,2, Caitlin Logan, PhD, MD1, Gabriella Fernandes-Cunha, PhD1, Peter Le, Bsc1, David Myung, PhD, MD1,3, 1Stanford University School of Medicine, Palo Alto, CA, USA, 2VA Palo Alto Medical Center, Palo Alto, CA, USA, 3Stanford University, Stanford, CA, USA P1183

627. Biophysical comparison of photocrosslinked gelatin-hyaluronate hydrogels designed for 3D bioprinting of corneal tissue Uiyoung Han, PhD1, David Myung, PhD, MD1,2,3, 1Stanford University School of Medicine, Palo Alto, CA, USA, 2Stanford University, Stanford, CA, USA, 3VA Palo Alto, Palo Alto, CA, USA P1184

Tissue Engineering (SIG)

628. 4D Bioprinted Tri-layer Scaffolds with Biomimetic and Hierarchical Structure for Uterine Tissue Regeneration Shangsi Chen, Liwu Zheng, Min Wang, The University of Hong Kong P1185

629. In situ graphene oxide incorporated glycol chitosan/oxidized hyaluronic acid injectable hydrogel for bone tissue regeneration in a rat calvarial bone defect model Haram Nah, PhD candidate1,2, Min Heo2, Jae-Hwan Choi1,2, Dong Nyoung Heo, Professor1,2, 1Kyung Hee University, Seoul, Republic of Korea, 2Biofriends Inc., Seoul, Republic of Korea P1186

630. Extracellular Tumor Microenvironment Influences Glioma Progression after Therapeutic Intervention Sara Pedron-Haba, Joseph Mueller, Achal Anand, Kimberly Selting, Brendan Harley, Edward Neves, University of Illinois Urbana-Champaign, Urbana, IL, USA P1187

631. Ruthenium-complex Nanomicelle Sensors for Reporting Oxygen Tension within the 3D Tumor Model Microenvironment, Kevin Schilling, Jr., PhD, Rachel Chapla, PhD, Carolyn Schutt, PhD, Oregon Health and Science University, Portland, OR, USA P1188

632. Human Ovarian Cortex Encapsulated in Immune-isolating Poly(ethylene glycol)-based Capsules Restores Cyclicity in Ovariectomized Mice, Margaret Brunette, Monica Wall, Cynthia Dela Cruz, PhD, Ariella Shikanov, PhD, University of Michigan, Ann Arbor, MI, USA P1189

633. Development of a Low-Cost 3D Printer for Multiplexing Bioprinting and Near-Field Electrospinning, Alyssa Salazar, BS, Justin Brown, PhD, The Pennsylvania State University, University Park, PA, USA P1190

634. Formation of Complex Multi-Cellular Structures of MSCs Embedded in Stress Relaxing PEG-HA Hybrid Hydrogels, Alexandra Borelli1,2, Mark Young1,2, Kristi Anseth1,2, 1University of Colorado, Boulder, Boulder, CO, USA, 2BioFrontiers Institution, Boulder, CO, USA P1191

635. Exploring the Effects of Microarchitecture on Astrocyte Behavior and Vascular Remodeling in Spinal Cord Injury, Devin Gerber, Inha Baek, Young Hye Song University of Arkansas, Fayetteville, AR, USA P1192

636. Collagen I hydrogel model to study the effects of diabetes on calcific aortic valve disease, Jessica Simon1, Maristella Donato1,2, Subramanian Dharmarajan, PhD1, Marta Scatena, PhD1, Cecilia Giachelli, PhD1, 1University of Washington, Seattle, WA, USA, 2University of Padua, Padua, Italy P1193

637. Investigation of Pore Shape on Cell Infiltration of Soy-based Resin via Vat Photopolymerization for Tissue Scaffolds Sera Choi, John Will, Keyton Feller, Christopher Williams, Virginia Tech P1194

638. Synthesis of norbornene-modified hyaluronic acid hydrogels via water-based DMTMM coupling, Eleanor Plaster, Madeline Eiken, Claudia Loebel, MD, PhD University of Michigan, Ann Arbor, MI, USA P1195

Translational Tissue Engineering Therapies in Preclinical Models of Injury and Trauma

639. Corticosteroid Eluting Endotracheal Tubes Impact Mechanical Properties in Laryngeal Burn Injury Model, Gabriela Cervantes-Gonzales, Teja GudaThe University of Texas at San Antonio, San Antonio, TX, USA P1196

640. In Vivo Efficacy and Biodistribution of Platelet-like Particles, Kimberly Nellenbach, Seema Nandi, Emily Mihalko, Jagathpala Shetty, L. Andrew Lyon, Jennifer Sollinger, Drew Koch, Lauren Schnabel, Ashley Brown, North Carolina State University and University of North Carolina at Chapel Hill P1197

Poster Session II - Thursday, April 20th, 5:45 PM - 7:15 PM

Biointerfaces (SIG)

641. In Vitro and In Vivo Degradation Correlations for Polyurethane Foams with Tunable Degradation Rates Mary Monroe, PhD1, Anand Vakil, PhD1, Natalie Petryk1, Changling Du1, Bryanna Howes2, Darnelle Stinfort1, Serenella Serinelli, MD3, Lorenzo Gitto3, Maryam Ramezani1, Henry Beaman, PhD1, 1Syracuse University, Syracuse, NY, USA, 2Le Moyne College, Syracuse, NY, USA, 3SUNY Upstate Medical University, Syracuse, NY, USA P2001

642. Derivatization of NO-Releasing Graphene Oxide Nanosheets for Antibacterial Biomaterials Mark Garren, Morgan Ashcraft, Dagney Crowley, Hitesh Handa, PhD, University of Georgia, Athens, GA, USA P2002

643. Antimicrobial Efficacy of Nitric Oxide-Releasing Silicone Rubber at Clinical Bacterial Loads Lori Estes Bright, Arnab Mondal, PhD, Anil Kumar, PhD, Stephen Thompson, Elizabeth Brisbois, PhD, Hitesh Handa, PhD, University of Georgia, Athens, GA, USA P2003

644. Surface Engineering of a Dual-Reactive Oxygen Species Strategy Against Device-Related Infection Mark Garren, Arnab Mondal, PhD, Morgan Ashcraft, PhD, Rashmi Pandey, Megan Douglass, PhD, Hitesh Handa, PhD, University of Georgia, Athens, GA, USA P2004

645. Investigation of calcospherites fusion by using apatite plate model YuYang Jiao, ChenLing Fang, Emilio Hara, Masahiro Okada, Takuya Matsumoto, Okayama University, Okayama, Japan P2005

646. Wrinkling Patterns on 4D-Printed Substrates and their Effect on Contact Guidance Johnson Agyapong1, Bo Van Durme1,2, James Henderson1, 1Syracuse University, Syracuse, NY, USA, 2Ghent University, Ghent, Belgium P2006

647. Investigating Bio-Nano Interactions of Polyamidoamine Dendrimers within Synovial Joints Juan Aleman, Brandon Johnston, Alan Grodzinsky, Paula Hammond, Simone Douglas-Green, Massachusetts Institute of Technology, Cambridge, MA, USA P2007

648. Nanoparticle polypropylene mesh composite utilizing calcium channel modulation for post-surgical adhesion prevention: an in-vitro study Jiahui Chen1, Junlang Li1,2, Yang Zhang1, Arielle Perez2, Martin King1,3, 1North Carolina State University, Raleigh, NC, USA, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 3Donghua University, Shanghai, China P2008

650. Enhancing Switchable Cell Adhesion to PNIPAAm Through Incorporation of Cationic Monomers Alexandria Brady-Mine, Ryan Toomey, PhD, Nathan Gallant, PhD, University of South Florida, Tampa, FL, USA P2009

651. Effects of nanopatterning on the Osteoimmunomodulatory response of titanium implants Andrea Mesa-Restrepo1, Viviana Posada2, Alexis Snyder1, Alexandru Marin2, Jean Paul Allain1,2, 1The Pennsylvania State University, University Park, PA, USA, 2The Pennsylvania State University, University Park, PA, USA P2010

652. Highly Porous Gas-Blown Hydrogels for Direct Cell Encapsulation with High Cell Viability Mary Beth Monroe, PhD, Henry Beaman, PhD, Syracuse University, Syracuse, NY, USA P2011

Biomaterials for Cell Therapy

653. Delivery of hair follicle dermal papilla cell spheroids into hairless mice using microneedles for alopecia treatment Moon Sung Kang, ME1, Rowoon Park, ME1, Suck Won Hong, PhD1, Ki Su Kim, PhD1, Seung Jo Jeong, ME2, Dong-Wook Han, PhD1, 1Pusan National University, Busan, Republic of Korea, 2Korea Seoul St. Mary’s Hospital, Seoul, Republic of Korea P2012

654. Effect of Microbeads Composition, Fabrication and Cryopreservation Processes and Cell Preconditioning on Survival and Function of Microencapsulated Cells Francesco Touani, MsC1,2, Shant Der Sarkissian, PhD1,2, Baptiste Marin, MSc1,3, Inès Hamouda, PhD1,3, Sophie Lerouge, PhD, Eng.1,3, 1CHUM research center (CRCHUM), Montreal, QC, Canada, 2Université de Montréal, Montreal, QC, Canada, 3Ecole de technologie supérieure (ÉTS), Montreal, QC, Canada P2013

655. Confirming the Extent and Mechanisms of the Immunosuppressive Enhancement of hMSCs Initiated by COL/HEP Layer by Layer Coatings Justin Putman, Konatsu Nagashima, Jorge Almodovar, The University of Arkansas, Fayetteville, AR, USA P2014

656. In-situ Photocrosslinked PEG Microgels as Delivery Platform for Human Mesenchymal Stem Cells Saron Ghebrezadik1,2, Ana Mora-Boza, PhD1, Andrés García, PhD1, 1Georgia Institute of Technology, Atlanta, GA, USA, 2Agnes Scott College, Decatur, GA, USA P2015

657. Use of Oxygen Sensitive Microcapsules to Assess MAA-PEG Induced Vascularization of the Subcutaneous Space Krystal Ortaleza, Michael Sefton, PEng, University of Toronto, Toronto, ON, Canada P2016

658. Targeting Neutrophils for Early Allogeneic Islet Survival in a Methacrylic Acid (MAA)-induced, Vascularized Subcutaneous Space So-Yoon Won, Michael Sefton, PhD, University of Toronto, Toronto, ON, Canada P2017

659. Novel LRP-1 targeted Exosome-Liposome hybrid nanoparticles for crossing the blood-brain barrier SURIDH CHAKRAVARTY, NEERAJA REVI, PhD, DIVYA BIJUKUMAR, PhD, UNIVERSITY OF ILLINOIS AT CHICAGO, ROCKFORD, IL, USA P2018

Biomaterials for Organoids

660. Extending the three-dimensional culture of adipocytes through surface coatings Sheetal Chowdhury, Zacchaeus Wallace, Maggie Moore, Courtney Cates, Gene Bidwell, Amol Janorkar, University of Mississippi Medical Center, Jackson, MS, USA P2019

661. Design and Development of a Microfluidic Platform for Colorectal Cancer Organoids on-a-chip Eleonora Zanrè, PhD1, Sara Micheli1,2, Andrea Biccari1,3, Francesca Sensi1, Edoardo D'Angelo1,3, Marco Agostini1,3, Elisa Cimetta1,2, 1Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy, 2Department of Industrial Engineering, Padova, Italy, 3Department of Surgical, Oncological and Gastroenterological Sciences, Padova, Italy. P2020

662. Development of a High-Throughput Bio-printable Organoid System Mimicking Complex Microenvironment Luda Lin, Peyton Tebon, PhD, Bowen Wang, Alice Soragni, PhD, University of California Los Angeles, Los Angeles, CA, USA P2021

663. Self-organized insulin-producing beta cells differentiated from human omentum-derived stem cells Yongsung Hwang, Ph.D.
Soonchunhyang Institute of Medi-bio Science, Soonchunhyang University, Cheonan, Republic of Korea P2022

664. Chemically Defined and Dynamic Gelatin-Based Hydrogel Supports Hair Cell Differentiation in Human Inner Ear Organoids Mahboubeh Jafarkhani1, Matthew Arkenberg1, Yoshitomo Ueda1, Chien-Chi Lin2, Eri Hashino1, 1Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA, 2Purdue School of Engineering & Technology, Indiana University-Purdue University, Indianapolis, IN, USA P2023

665. Incorporating Vasculature into Cortical Organoids using a 3D Bioprinted Platform Melissa Cadena1,2, Anson Sing, PhD2, Kylie Taylor2, Liqun Ning, PhD1,2, Samantha Lanjewar2, Martin Tomov, PhD1,2, Steven Sloan, MD, PhD1,2, Vahid Serpooshan, PhD1,2,3, 1Georgia Institute of Technology, Atlanta, GA, USA, 2Emory University School of Medicine, Atlanta, GA, USA, 3Children's Healthcare of Atlanta, 30322, GA, USA P2024

666. Cell adhesion peptide functionalized nanofibrillar scaffold for induced pluripotency stem cell spheroid engineering Wanho Cho1, Duc-Hoai-Thuong Bui1, Hyuk Sang YOO, PhD1, Jinhee Park, Ju hyun Park, 1kangwon national university, Chuncheon, Republic of Korea P2025

667. 3D micro tissue-microfluidic platform for development of drug screening for treatment or prevention of chronic kidney disease Kyeong-min Lee, Yeo jin Hwang, Eunjoo Kim, Jung-hee Kim, Eun-sook Choi, Chaewon Jin, Jinyoung Kim, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea P2026

Biomaterials for the Lungs

669. Tuberculosis Treatment Strategies Through Sustained Local Delivery Emmanuel Opolot, Horst von Recum, Case Western Reserve University, Cleveland, OH, USA P2028

670. Bleomycin-Induced Pulmonary Fibrosis Reveals Temporal Drivers of Fibrotic and Remodeling Biophysical States Jason Guo, PhD, Michelle Griffin, MD, PhD, Nicholas Guardino, BS, Darren Abbas, MD, John Lu, BS, Asha Cotterell, BS, Jennifer Parker, BS, Derrick Wan, MD, FACS, Michael Longaker, MD, MBA, FACS, Stanford University School of Medicine, Stanford, CA, USA P2029

671. Engineered 3D hydrogels to probe mechanisms of matrix stiffness within lung alveolar epithelial organoids Madeline Eiken, Jason Spence, PhD, Claudia Loebel, MD, PhD, University of Michigan, Ann Arbor, MI, USA, P2030

672. Mesenchymal Stem Cell Extracellular Matrix Nanoparticles Possess Proliferative and Antibacterial Effects Emily Wandling, Keera Rhoads, Karah Moore, Rebecca Heise, PhD, Virginia Commonwealth University, Richmond, VA, USA  P2031

673. Myofibroblast De-differentiation and Fibrotic Tissue Reversion in a Synthetic 3D Interstitial Matrix Jingyi Xia1, Daniel Matera1, Ethan Poupard1, Vincent Fiore2, Brendon Baker1, 1University of Michigan Ann Arbor, Ann arbor, MI, USA, 2Boehringer Ingelheim, Ridgefield, CT, USA P2032

674. Tunable Polymeric Microparticles for Delivery of Anti-Inflammatory Therapeutics to Macrophages Emerson Grey1, Scott Alper2, William Janssen2, Stephanie Bryant1, 1University of Colorado Boulder, Boulder, CO, USA, 2National Jewish Health, Denver, CO, USA P2033

675. Treatment of Acute Pulmonary Inflammation with Engineered Extracellular Vesicles in a Murine Model Changes the Metabolic Profile of the Lungs while Successfully Dampening Inflammation Tatiana Cuellar-Gaviria, PhD, Ana Salazar-Puerta, María Rincon-Benavides, Julian Aldana, Daniel Gallego-Perez, PhD, Natalia Higuita-Castro, PhD, The Ohio State University, Columbus, OH, USA P2034

676. Alveolar macrophages drive lung fibroblast function in co-cultures of IPF and normal patient samples Caymen Novak, PhD, Jana Wheat, Samir Ghadiali, PhD, Megan Ballinger, PhD, The Ohio State University, Columbus, OH, USA P2035

677. Matrix Stiffness Alters Microvascular Sprouting in a PEG Hydrogel Model of Idiopathic Pulmonary Fibrosis Julie Leonard-Duke, Anthony Bruce, Shayn Peirce, Lakeshia Taite, University of Virginia, Charlottesville, VA, USA P2036

678. Endothelial Cell-Pericyte Interactions in a PEGDA Hydrogel Co-Culture Model of Idiopathic Pulmonary Fibrosis Tara Tavakol1, Anna Kittel1, Julie Leonard-Duke1, Yixuan Yuan1, Caleb Tyson2, Annika Szyniec1, Shayn Peirce1, Lakeshia Taite1, 1University of Virginia, Charlottesville, VA, USA, 2Hampton University, Hampton, VA, USA P2037

1050. An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung, Rachel Ringquist, Ankur Singh, Krishnendu Roy, Georgia Institute of Technology. P2189

Biomaterials for Women's Health

679. Cancer Engineering a three-dimensional multilayer multicellular model of endometrial cancer for high throughput drug screening Ines Cadena, Mina Buchanan, Kaitlin Fogg, Oregon State University, Corvallis, OR, USA P2038

680. Early Development of a Low-Cost Ethyl Cellulose Injector for Cervical Pre-Cancer Ablation Venkata Sarojasamhita1, David Garvey, BS1,2, Jenna Mueller, PhD1, Martha Wang, PhD1,2, Kevin Aroom, PE1,2, 1Fischell Department of Bioengineering, College Park, MD, USA, 2Fischell Institute for Biomedical Devices, College Park, MD, USA P2039

681. Developing a Hyaluronic Acid-Based Hydrogel Platform to Probe Ovarian Follicle-Extracellular Matrix Interactions Emily Thomas, Nickolas Hoffman, Yuhong Lu, Ariella Shikanov, University of Michigan, Ann Arbor, MI, USA P2040

682. EGFR-targeted Lipid Nanoparticles for Selective mRNA Delivery to the Placenta Hannah Geisler, Aditi Ghalsasi, Michael Mitchell, PhD University of Pennsylvania, Philadelphia, PA, USA P2041

683. Redox-Initiated Cure Improves Uniformity of Shape Memory Foams for Self-fitting Vaginal Stents Ashley Hicks1, Arian Veyssi1, Courteney Roberts2, Melissa Grunlan2, Julie Hakim3, Elizabeth Cosgriff-Hernandez1, 1University of Texas at Austin, Austin, TX, USA, 2Texas A&M University, College Station, TX, USA, 3Baylor College of Medicine, Houston, TX, USA P2042

Challenges and Opportunities in Translating Emerging Biomaterials Technologies Amid Papers, Patients, and Practice

684. Translation of a bioactive calcium alkali orthophosphate (CAOP) bone grafting material from bench to bedside & effect of this Si-CAOP on craniofacial bone regeneration and angiogenesis in humans Christine Knabe, PhD1, Tom Knauf, PhD1, Renate Gildenhaar2, Georg Berger, PhD2, Jens Guenster, PhD2, Janka Wilbig2, Doaa Adel-Khattab, PhD3, Alexander Rack, Phd4, Michael Stiller, PhD1, 1Philipps University Marburg, Marburg, Germany, 2Federal Institute for Materials Research and Testing, Marburg, Germany, 3Ain Shams University, Cairo, Egypt, 4European Synchroton Radiation Facility, Grenoble, France P2043

685. Advancing Non-Viral Delivery Vehicle Discovery via Battelle’s HIT SCAN Platform Kenneth Sims, Jr., PhD, Danielle Huk, PhD, Cherry Gupta, PhD, Michael Riedl, PhD, Caleb Hillrich, Emma Schmitz, Ashlee Colbert, PhD, Zachary Shank, Morris Makobongo, PhD, Andrea McCue, PhD, Joanna Hoy, Allison Secard, Chelsi Snow, PhD, PMP, Anthony Duong, PhD, Battelle Memorial Institute, Columbus, OH, USA P2044

Computational Approaches for Biomaterial Design

686. Modeling of Carbon Monoxide Delivery for Treating Disruptions in the Blood Brain Barrier Endothelium Rubens Jourdain, Tanya Enderly, Venkat Keshav Chivukula, PhD, Chris Bashur, PhD, Florida Institute of Technology, Melbourne, FL, USAP2045

Computationally Driven Biomaterials and Machine Learning

688. Machine Learning Analysis of Matrix Architecture Following Treatment of Abdominal Adhesions Jason Guo, PhD, Deshka Foster, MD, PhD, Norah Liang, MD, Charlotte Berry, BS, Jack Li, MD, PhD, Michael Januszyk, MD, PhD, Gerlinde Wernig, MD, Jeffrey Norton, MD, FACS, Michael Longaker, MD, MBA, FACS, Stanford University School of Medicine, Stanford, CA, USA P2047

689. Lipid Metabolomics for Characterization of Mesenchymal Stromal Cell Fitness on Biomaterial Culture Surfaces Molly Ogle, PhD1, Joseph Corstvet2, Daniel Vallejo, PhD2, Facundo Fernandez, PhD2, Johnna Temenoff, PhD1, 1Georgia Institute of Technology & Emory University, Atlanta, GA, USA, 2Georgia Institute of Technology, Atlanta, GA, USA P2048

690. ML-based Prediction of Hydrogel Gelation Kinetics and their Mechanical Properties Gloria Pinilla, M.Sc, Dimitria Camasao, Cedric Schmitt, Anis Henni Rheolution Inc, Montreal, QC, Canada P2049

691. Combined Experimental and Machine Learning Approach to Classifying Cardiomyocyte Content and Clustering Structural Maturation of Differentiated Hydrogel-encapsulated HiPSCs Mohammadjafar Hashemi1, Samira Mohammadi1, Shenbageshwaran Rajendiran, Ferdous Finklea, Selen Cremaschi, Elizabeth Lipke, 1Auburn University, AUBURN, AL, USA P2050

Drug Delivery (SIG)

692. Spray-dried keratin nanoparticles with varied hair protein fractions for drug delivery application Yang Wei, National Taipei University of Technology, Taipei, Taiwan P2051

693. Non-immunogenic Ligand-targeted PEG-b-PPS Micelles Blocks AKT Pathway in Endothelial Cells Neeraja Revi1, Ritu Padaria, MS1, Divya Bijukumar, PhD1, Evan Scott2, 1College of medicine Rockford, University of Illinois at chicago, Rockford, IL, USA, 2Northwestern University, Evanston, IL, USA P2052

694. Prolonged Release of Insulin for Use in Diabetes Management and Tolerogenic Vaccines Leslee Nguyen1, Caitlin Maikawa, PhD1,2, Eric Appel, PhD1, 1Stanford University, Stanford, CA, USA, 2Harvard University, Boston, MA, USA P2053

695. Lipid Based Nanoparticle Delivery System for Pulmonary Route of Administration Vidit Singh1, Anna Chernatynskaya1, Lavanya Bhargava1, Hu Yang, PhD1, Yang Wang, PhD2, Weixing Hao2, Marcus Oliviera2, 1Missouri University of Science and Technology, Rolla, MO, USA, 2University of Miami, Coral Gables, FL, USA  P2054

696. Novel Mesh Formulation for Targeted Delivery of Chemotherapeutic Drugs Ummay Mowshome Jahan1, Alyssa Peace, MD2,3, Martin W. King, PhD1,4, Andrea A. Hayes, MD, PhD2,5, 1North Carolina State University, Raleigh, NC, USA, 2University of North Carolina, Chapel Hill, NC, USA, 3university of Colorado, Aurora, CO, USA, 4Donghua University, Chang Ning Qu, China, 5Howard University Hospital, Washington, DC, USA P2055

697. Nanosilicate Hydrogel Composites for Sustained Therapeutic Delivery Samuel Stealey1, Akhilesh Gaharwar, PhD2, Silviya Zustiak, PhD1
1Saint Louis University, Saint Louis, MO, USA, 2Texas A&M, College Station, TX, USA P2056

698. Formulation of lipid/ polymer hybrid nanoparticles in microfluidics for plasmid DNA (pDNA) delivery Diviya Santhanes, BPharm (Hons), Huiming Zhang, PhD, Alex Wilkins, BBiotech (Hons), Anne-Louise Gannon, PhD, John Aitken, PhD, Roger Liang, PhD, The University of Newcastle, Newcastle, New South Wales, Australia P2057

699. Choline-Decorated Biodegradable Polymeric Nanoparticles for Anti-Cancer Effects Nae Hak Park, Han Chang Kang, PhD The Catholic University of Korea, Bucheon, Republic of Korea P2058

700. EnteroPatho Nanoparticles for the Oral Delivery of Biologics Isabela Ramirez Velez, Nicholas Peppas, D. Eng., Sc.D., Brian Belardi, PhD The University of Texas at Austin, Austin, TX, USA P2059

701. Shear-induced embeddable microneedle patches for hair loss treatment Keum-Yong Seong1, Min-Jae Kim1, Hye Seon Lee1, Sodam Kim1, Seung Soo Lee2, Hoon-Soo Kim3, Beum-Soo An1, Seung Yun Yang1, 1Pusan National University, Miryang-si, Republic of Korea, 2SNVIA Co., Ltd., Busan, Republic of Korea, 3Pusan National University Hospital, Busan, Republic of Korea P2060

702. Gellan Gum And Trilysine Hydrogels with Tunable Mechanical Properties for Drug Delivery Carolina Villarreal1,2, Jeannine Coburn, PhD1 1Worcester Polytechnic Institute, Worcester, MA, USA, 2Boston Scientific, Marlborough, MA, USA P2061

703. Analysis of Calcium Sulfate Bone Graft Materials With the Incorporation of Antibiotics and Antifungals Julia Strecker, Joel Bumgardner, Scott Noel, Jessica Jennings, University of Memphis 1, University of Memphis 2, Austin Medical Ventures, Inc P2062

704. Temporally Controlling the Release of Biofactors from Polymeric Microspheres Sebastian Kharileh, Liam Fitzgerald, PhD, Samhita Popuri, Kathrina Etienne, Brittany Taylor, PhD, University of Florida, Gainesville, FL, USA P2063

705. Antiviral Delivery from Endotracheal Tube Coating Temporally Modulates Airway Inflammation in Swine Teja Guda, Gabriela Cervantes-Gonzales The University of Texas at San Antonio, San Antonio, TX, USA P2064

706. Carrier-free self-assembled Palmitic-DEVD-doxorubicin nanoparticles for Anicancer Therapy Seong-Bin Yang, Dong-Nyeong Lee, Jooho Park Konkuk university, Chungju-si, Republic of Korea P2065

707. Characterizations of PLA-PMAA/PBA block copolymer forming micelles for ophthalmic drug delivery applications Lina Liu, Talena Rambarran, PhD, Heather Sheardown, McMaster University, Hamilton, ON, Canada P2066

708. Evaluation of transfection efficacy, biodistribution, and toxicity of Branched Amphiphilic Peptide Capsules (BAPCs) associated with mRNA, Adriana Avila Flores, PhD, Auburn University, Auburn, AL, USA P2067

709. Evaluation of the Performance of Breast Cancer-Targeted Nanocarriers Triggered by High-Frequency Ultrasound and Microbubbles Waad AbuWatfa, MS in Chemical Engineering, Shabana Anjum, PhD, Ghaleb Husseini, PhD, American University of Sharjah, Sharjah, United Arab Emirates P2068

710. The effect of lipid composition on low-frequency ultrasound calcein release from Trastuzumab liposomes for breast cancer treatment, Nour Alsawaftah, MS, Nahid Awad, PhD, Vinod Paul, MS, Ghaleb Husseini, PhD, American University of Sharjah, Sharjah, United Arab Emirates P2069

711. Ultrasound-mediated Release of Curcumin from nanoliposomes and Cytotoxicity Studies on the Breast Cancer Cell Line HCC 1954 Vinod Paul, MS, Remya Radha, PhD, Ghaleb Husseini, PhD American University of Sharjah, Sharjah, United Arab Emirates P2070

712. Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes Najla Salkho, MS, Hana Sulieman, PhD, Zeyad AlMajed, MS, Ghaleb Husseini, PhD, American University of Sharjah, Sharjah, United Arab Emirates P2071

713. Application of Random Forest Regressor for the Prediction of Estrone – Liposomal Drug Release at different Ultrasound Power Densities Ibrahim Shomope, Nabil Abdeljabbar, PhD, Ghaleb Husseini, PhD, American University of Sharjah, Sharjah, United Arab Emirates P2072

714. Release of Calcein from eLiposomes via Acoustic Stimulation: A Study for Enhancing Sonosensitivity of Liposomes Mah Noor Zafar, BS, Ghaleb Husseini, PhD, American University of Sharjah, Sharjah, United Arab Emirates P2073

715. Varying Formulation Methods to Achieve Desired Diameter of Poly (caprolactone) Particles to Treat Disease. Claire Rowlands, Ashbey Manning, Hope Saindon, Brittany Givens, PhD, University of Kentucky, Lexington, KY, USA P2074

717. Intratumoral Injection of a Novel Hydrogel Drug Delivery System Achieves 10 Millimeters of Drug Diffusion in the Brain Tumor Microenvironment Elizabeth Barker, PhD1, Anna Jones, Jenny Patel, PhD, 1University of Tennessee, Knoxville, TN, USA P2076

718. Local Drug Delivery of Doxorubicin Achieves Complete Response in a Preclinical Pediatric Brain Tumor Model Elizabeth Barker, PhD1, Anna Jones, Jenny Patel, PhD, 1University of Tennessee, Knoxville, TN, USA P2077

Emerging Innovations and Translation in Orthopedic Biomaterials Science and Engineering

719. Histomorphometric analysis of rat femur refractory defect repair by an octacalcium phosphate composite Osamu Suzuki, PhD, FBSE1, Yu Mori, PhD, MD2, Ryo Hamai, PhD1, Ryuichi Kanabuchi, PhD, MD2, Soshi Hamada, PhD, MD2, Yukari Shiwaku, PhD, DDS, Naohisa Miyatake, PhD, MD1,2, Kazuyoshi Baba, PhD, MD2, Itsuki Oizumi, PhD, MD2, Kaori Tsuchiya, MSc1, Toshimi Aizawa, PhD, MD2, 1Tohoku University Graduate School of Dentistry, Sendai, Japan, 2Tohoku University Graduate School of Medicine, Sendai, Japan P2078

720. Cell-Resorbable Bone Cements for Orthopedic Implant Fixation Reinaldo Dos Santos, Ardeena Ahmed, Brooke Hunn, John Martin, PhD, University of Cincinnati, Cincinnati, OH, USA P2079

721. A Corrosion Study of WE43 and ZX10 Alloy Wires for Multiple Biomedical Applications Beril Ulugun1, Amber Robinson2, Sarah Abduljabbar3, Ryan Guilbault4, Adam Griebel5, Greg Osgood4, Warren Greyson1, Timothy Weihs1, 1Johns Hopkins University, Baltimore, MD, USA, 2Morgan State University, Baltimore, MD, USA, 3Texas A&M University, College Station, TX, USA, 4The Johns Hopkins University School of Medicine, Baltimore, MD, USA, 5Fort Wayne Metals, Fort Wayne, IN, USA P2080

722. Long Term Effects of Storage Condition and Antioxidants on Oxidative Behavior of Free Radicals in UHMWPE Afsana Sharmin, Muhammad Jahan, PhD, University of Memphis, Memphis, TN, USA P2081

723. A Study on the Biomechanical Effect of the Vertebral Body According to the Lumbar L4-L5 Disc Height under the Same Load Condition Sungwook Kang1, Dongmin Kim1, Jae-Gyeong Jeong2, Jong-Moon Hwang2, Sang-Youn Song3, Dong-Hee Kim3, 1Korea Institute of Industrial Technology, Jin-ju, Republic of Korea, 2Kyungpook National University Hospital, Dae-gu, Republic of Korea, 3Gyeongsang National University, Jin-ju, Republic of Korea P2082

724. In Vitro Osteogenic Performance of Two Novel Strontium and Zinc-Containing Glass Polyalkenoate Cements Daniella Marx, BSc, PhD1, Alireza Rahimnejad Yazdi, PhD1, Marcello Papini, PhD, PEng, FCSME1, Mark Towler, BSc, MSc, PhD, CEng2, 1Toronto Metropolitan University, Toronto, ON, Canada, 2Missouri University of Science and Technology, Rolla, MO, USA P2083

Engineering Cells & Their Microenvironments (SIG)

725. Bioprinted Fibroblasts show some Hallmarks of Pluripotency by Immunofluorescence and RNA Seq Analysis Thomas Boland, Patricia Ablanedo Morales, Kayla Molina, Michael Furth, Jonathon Mohl, The University of Texas at El Paso, El Paso, TX, USA P2084

726. Physicochemical Surface-Driven Ceiling Culture Method for Improving Dedifferentiated Fat Cell Rate Aslı Karanfil1, Fiona Louis, PhD2, Yoshihiro Sowa3,4, Michiya Matsusaki, PhD1,2,1Graduate School of Engineering, Osaka University, Osaka, Japan, 2Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan, 3Department of Plastic and Reconstructive SurgeryGraduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Plastic and Reconstructive Surgery, Graduate School of Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan P2085

727. Brain Microvascular Endothelial Cells Exhibit Altered Claudin-5 Expression Following Inflammatory Assault Katherine Ebbert, Rui Chen, Robert Culibrk, Daniel Yeisley, Mariah Hahn, PhD, RENSSELAER POLYTECHNIC INSTITUTE, Troy, NY, USA P2086

728. The Effect of Substrate on the Mechanical State of the Cell Elizabeth Byers, Justin Brown, PhD, The Pennsylvania State University, University Park, PA, USA P2087

Engineering Complex Tissues

729. Engineered Bone for Preclinical Modeling of Prostate Cancer Metastatic Tumor Sergio Barrios1,2, Stefan Maksimovic2, Antonios Mikos, PhD1, Eleonora Dondossola, PhD2, 1Rice University, Houston, TX, USA, 2MD Anderson Cancer Center, Houston, TX, USA P2088

730. Effects of Matrix Composition and Stiffness on Astrocyte Cell Response in Xeno-Free Biomimetic Brain ECM Models Bayan Saleh, Ayda Pourmostafa, Nashaita Patrawalla, Vipuil Kishore, Florida Institute of Technology, Melbourne, FL, USA P2089

731. Gelatin as a Sacrificial Network to Enable Multi-Material Volumetric Additive Manufacturing of Hydrogels Morgan Riffe, Abhishek Dhand, Matthew Davidson, PhD, Megan Cooke, PhD, Gabriel Seymour, Robert McLeod, PhD, Jason Burdick, PhD, University of Colorado Boulder, Boulder, CO, USA P2090

732. Photo-responsive Synthetic Hydrogels for the Culture of Murine Intestinal Stem Cell Derived Monolayers Mark Young1,2, Colter Oroke1, Alexandra Borelli1,2, Max Yavitt1,2, Peter Dempsey, PhD3, Kristi Anseth, PhD1,2, 1University of Colorado Boulder, Boulder, CO, USA, 2BioFrontiers Institution, Boulder, CO, USA, 3University of Colorado Anschutz, Aurora, CO, USA P2091

733. Epicardial-coated cardiac tissue engineered constructs for modelling of ischemia reperfusion injury Dawn Bannerman1,2, Simon Pascual-Gil, PhD2, Qinghua Wu, PhD1,2, Karl Wagner1,2, Sargol Okhovatian1,2, Milica Radisic, PhD1,2, 1University of Toronto, Toronto, ON, Canada, 2Toronto General Hospital Research Institute, Toronto, ON, Canada P2092

734. Computational pipeline for the design of multi-organ type 2 diabetes microphysiological system Ishan Goswami1, Lin Qi1, Marko Groeger2, Aditi Sharma2, Phichitpol Carnese2, Vernoica Cochrane2, Sudipta Ashe2, Matthias Hebrok2, Edward Hsiao2, Holger Willenbring2, Andreas Stahl1, Kevin Healy1, 1University of California Berkeley, Berkeley, CA, USA, 2University of California San Francisco, San Francisco, CA, USA P2093

Fibrous Biomaterials for Tissue Engineering

735. Engineering a Biomaterial-based in vitro Skeletal Muscle Tissue Platform Elizabeth Aikman, Asha Rao, Emily Fussell, Valeria Mejia, Whitney Stoppel, PhD, University of Florida, Gainesville, FL, USA P2094

736. Investigation of non-ionic surfactant effects on aligned fiber morphology and macroscopic scaffold properties Katherine Meinhold, Tyler Tankersley, Jennifer Robinson, University of Kansas, Lawrence, KS, USA P2095

737. HABP Functionalized Electrospun PCL Fibers as a Candidate for Building an Artificial Synovial Membrane Tugba Ozedmir, Scott Wood, Hosein Mirazi, South Dakota School of Mines and Technology P2096

738. ECM-mimetic synthetic fibrillar hydrogel with macroscopic stability and microscopic dynamics enhances cell mechanosensing in 3D Xian Xie1, Zhuo Li1, Liting Duan1, Liming Bian2, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2South China University of Technology, Guangzhou, China P2097

739 The impact of the microenvironment on cardiac differentiation of human induced pluripotent stem cells Kiran Ali, MS, Christopher Watts, Lucy Payne, Jessica Gluck, Assistant Professor North Carolina State University, Raleigh, NC, USA P2098

740 Zinc Particles Embedded Electrospun Fiber Mesh for Controlled Release Study and Wound Healing Application Felix Tettey, Narayan Bhattarai, Sheikh Saudi, Salil Desai, North Carolina Agricultural and Technical State University, Greensboro, NC, USA P2099

741. Spatially Controlling Mineralization Via Photoconjugation of Calcium-Binding Peptides on Norbornene-Modified Cellulose Sanika Suvarnapathaki, PhD, Julianne Holloway, PhD, Arizona State University, Tempe, AZ, USA P2100

742. Electrospun Fibrous Mesh of Poliglecaprone Blended Polycaprolactone for Biomedical Application Narayan Bhattarai, Felix Tettey, Grad Student, Jaclynn Siler-Dearring, Alexis Moody, North Carolina Agricultural and Technical State University, Greensboro, NC, USA P2101

743. Iron-Chelated Silk Microfibers as a Novel Magneto-Responsive Scaffold Architecture Melissa Wojnowski, BS, MS, Jeannine Coburn, PhD Worcester Polytechnic Institute, Worcester, MA, USA P2102

744. Effect of Collector Polarity on Electrospun Polycaprolactone Mackaylee Cudworth, Francisco Chaparro, PhD Nanoscience Instruments, Phoenix, AZ, USA P2103

745. Fabrication and Analysis of the Mechanical Properties of Polycaprolactone-Zinc Nanofibers for Biomedical Applications Mackenzie Long, Felix Tettey, Narayan Bhattarai, North Carolina Agricultural & Technical State University, Greensboro, NC, USA P2104

746. Tailored Nanofiber Microspheres with Tunable Morphology for Accelerated Diabetic Wound healing Johnson John, Terasaki Institute. P2105

Granular Hydrogel Scaffolds

747. Combinatorial Microgel Scaffolds with Distinct ECM Protein and Stiffness Modulate Hepatic Stellate Cell Activation Hyeon Ryoo, M.S., Gregory Underhill, PhD, University of Illinois at Urbana-Champaign, Urbana, IL, USA P2106

748. Spatially-Defined Cell-Secreted Protein Detection Using Granular Hydrogels: µGeLISA Hyeon Ryoo, M.S., Gregory Underhill, PhD
University of Illinois at Urbana-Champaign, Urbana, IL, USA P2107 

749. Surface Functionalization of Microgel Building Blocks in Granular Hydrogel to Direct Stem Cell Fate Junzhe Lou, PhD1,2, Charlotte Meyer1,3, David Mooney1,2, 1Harvard University, Cambridge, MA, USA, 2Wyss Institute, Boston, MA, USA, 3ETH Zürich, Zürich, Switzerland P2108

750. Gelatin Maleimide Granular Hydrogels as a Model to Study Glioblastoma Brittany Payan, B.S., Gunnar Thompson, B.S., Brendan Harley, Sc.D.
University of Illinois Urbana-Champaign, Champaign, IL, USA P2109

751. A Hierarchically Porous, Fiber-enhanced Microparticle Scaffold for in vitro Vascularization Jack Whitewolf, Gregory Grewal, Nina Brooks, Christopher Highley, PhD, University of Virginia, Charlottesville, VA, USA P2110

752. Extrusion Bioprinting of Nanoengineered Granular Hydrogel Scaffolds with Preserved Microporosity Amir Sheikhi, PhD, Zaman Ataie
The Pennsylvania State University, University Park, PA, USA P2111

753. Granular Hydrogels with Inter-particle Crosslinking as Injectable and Printable Biomaterials Ryan Davis, Hung Pang Lee, PhD, Kaivalya Deo, PhD, Satyam Rajput, Akhilesh Gaharwar, PhD, Texas A&M University, College Station, TX, USA P2112

754. Measurement of Cell-Mediated Extracellular Matrix Remodeling in a Granular Hydrogel Scaffold Gunnar Thompson1, Krutarth Kamani1, Alison Nunes1, Vincent Lam1, Sydney Nelson1, Andrés García2, Simon Rogers, PhD1, Brendan Harley, ScD1, Ana Mora-Boza, PhD2
1University of Illinois Urbana-Champaign, Urbana, IL, USA, 2Georgia Institute of Technology, Atlanta, GA, USA P2113

755. Molecular weight of hyaluronic acid crosslinked into biomaterial scaffolds affects angiogenic potential Josh Karam, PhD1, Breahna Singer2, Hiromi Miwa, PhD1, Limin Chen, PhD2, Mahdi Hasani, PhD1, Hsin-Chih Yeh2, Song Li, PhD1, Dino Di Carlo, PhD1, Stephanie Seidlits, PhD2
1University of California, Los Angeles, Los Angeles, CA, USA, 2University of Texas at Austin, Austin, TX, USA P2114

Immune Engineering (SIG)

756. Role of degree of crystallinity of biomaterials on modulation of immune responses Arezoo Esrafili, Gabriel Nile, Abhirami Thumsi, Abhirami Suresh, Madhan Jaggarapu, Nicole Appel, Kailong Jin, Abhinav Acharya, Arizona State University, Tempe, AZ, USA P2115

757. In Situ PEGylation of CAR T Cells Alleviates Cytokine Release Syndrome and Neurotoxicity Ningqiang Gong, Michael Mitchell, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann Metzloff, Margaret Billingsley, Alex Hamilton, University of Pennsylvania, Philadelphia, PA, USA P2116

758. Oxidized Lipid Nanoparticles for in situ CAR Monocyte Engineering Alvin Mukalel, Margaret Billingsley, Jacqueline Li, Ajay Thatte, Michael Mitchell, PhD, University of Pennsylvania, Philadelphia, PA, USA P2117

759. Acute Inflammatory Subcutaneous Model Facilitates Ectopic Gene Immuno-Engineering In-Situ Ana Panic, Ohio State University, Columbus, OH, USA P2118

760 Using Artificial Antigen-Presenting Cells to Generate Cytotoxic CD4+ T Cells In Vitro Gohta Aihara1, Ariel Isser, PhD1, Joseph Choy2, Mara Lanis1, Jonathan Schneck, PhD, MD1, 1Johns Hopkins School of Medicine, Baltimore, MD, USA, 2Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA P2119

761. Induction of Antigenic Tolerance for Applications in Multiple Sclerosis Rebeca Stiepel, Sean Simpson, PhD, Denzel Middleton, PhD, Nicole Lukesh, Luis Ontiveros-Padilla, PhD, Dylan Hendy, Erik Pena, Christopher Genito, PhD, Eric Bachelder, PhD, Kristy Ainslie, PhD
University of North Carolina Chapel Hill, Chapel Hill, NC, USA P2120

762. Raising Mucosal and Systemic Immune Responses Against Complement Anaphylatoxins for Inflammatory Disease. Helena Freire Haddad, Kelly Hainline, PhD, Elizabeth Curvino, Joel Collier, PhD, Duke University, Durham, NC, USA P2121

763. Immunomodulatory lipid-based nanoparticles for controlling and treating obesity Alireza Hassani Najafabadi, Neda Mohaghegh, Danial Khorsandi, Fatemeh Zehtabi, Hamed Nouri, Amir Ahari, Ali Khademhosseini, Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA P2122

764. Re-engineering REGvac for Rheumatoid Arthritis Immunotherapy Allen Tu1, Jamal Lewis1,2, Riley Allen1, 1University of California, Davis, Davis, CA, USA, 2University of Florida, Gainesville, FL, USA P2123

765. A Mucoadhesive, Paracellular Transport-Enhancing Conjugate Vaccine for Respiratory Infections Julia Zhou, BS, Scott Wilson, PhD
Johns Hopkins University, Baltimore, MD, USA P2124

766. Macrophage Immunotherapy with Nanogel-Cytokine Bioconjugates Rana Ajeeb, B.S.1, Danuta Radyna1, John Clegg1,2,3,4
1The University of Oklahoma, Norman, OK, USA, 2Stephenson Cancer Center, Oklahoma City, OK, USA, 3Harold Hamm Diabetes Center, Oklahoma City, OK, USA, 4Institute for Biomedical Engineering, Science, and Technology, Norman, OK, USA P2125

Immunomodulatory Biomaterials

767. Sustained Release of Macrophage-Targeted Nanoparticles Enables Long-term Control of Macrophage Phenotype Shreya Soni, M.S., Arielle D'Elia, M.S., Sylvia Cho, Christopher Rodell, Ph.D. Drexel University, Philadelphia, PA, USA P2126

768. Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration Matthew Kerr, Nisarg Shah, PhD
University of California, San Diego, La Jolla, CA, USA  P2127

769. Sialic Acid-Blocking Nanoparticles Modulate Inflammation Loise Råberg, Gizem Erensoy, Alexandra Stubelius
Chalmers University of Technology, Göteborg, Sweden  P2128

770. Modulating Macrophage Polarization Using Surface Roughness of Electrospun Fibrous Mesh Aidan Alemifar, Samuel Hurt, Jennifer Robinson
University of Kansas, Lawrence, KS, USA P2129

771. Influence of Biotin-Avidin-Modified Biomaterials on Macrophage Phenotype Victoria Nash, MS, Jessica Eager, MS, Erin O'Brien, Kara Spiller, PhD
Drexel University, Philadelphia, PA, USA  P2130

772. Biofunctional biomaterial design to reduce macrophage activation for chronic wound healing Aakanksha Jha, Joseph Larkin, III, PhD, Erika Moore, PhD, University of Florida, Gainesville, FL, USA   P2131

773. Dexamethasone-Decorated Poly(ε-caprolactone) Nanoparticles for Anti-Inflammatory Effects Joo Hee Hyun, Hana Cho, PhD, Han Chang Kang, PhD
The Catholic University of Korea, Bucheon, Republic of Korea   P2132

774. Physico-chemical characterization of an immunomodulatory bacterial exopolysaccharide polyelectrolyte coating Romain Bagnol1,2, Liam O'Mahony3, Vincent Barnier4, David Eglin2,4, Fintan Moriarty1, 1AO Research Institute Davos, Davos Platz, Switzerland, 2University of Twente, Enschede, Netherlands, 3University College Cork, Cork, Ireland, 4Mines Saint-Etienne, Saint-Etienne, France  P2133

775. Bispecific antibody-nanoparticle conjugate for receptor crosslinking of lymph node T cells Alexander Heiler1,2, Susan Thomas, PhD2,3,4,5
1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA, 2Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA, 3Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA, 4George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA, 5Winship Cancer Institute, Emory University, Atlanta, GA, USA   P2134

776. Low-Swelling, Amphiphilic Hydrogels for Local Anti-Inflammatory Drug Delivery Stephen Linderman, MD, PhD1,2, Daniel Refai, MD2, Adam Klein, MD, FACS2, Andres Garcia, PhD, FBSE1, 1Georgia Institute of Technology, Atlanta, GA, USA, 2Emory University, Atlanta, GA, USA
777 Augmentation of Oral Immunotherapy with Tolerance-induce Nanoparticles Rian Harriman, Allen Tu, Nicolas Radoc, Hamilton Kakwere, Jamal Lewis
UC Davis, Davis, CA, USA   P2135

778. Alginate-Based Artificial Antigen Presenting Cells Improve CD8+ T cell Memory Formation Mary Omotoso, Savannah Est-Witte, Sarah Neshat, Jordan Green, PhD, Jonathan Schneck, MD, PhD, Johns Hopkins University, Baltimore, MD, USA P2137

779. Combining Adjuvants and Biomaterials Appropriately Enhances Stimulation of Aged Dendritic Cells Ananya Ananya1,2,3, Kaitlyn Holden2,3,4, Zhiling Gu3,5, Dan Nettleton3,5, Surya K. Mallapragada1,2,3, Michael J. Wannemuehler2,3,6, Marian L. Kohut2,3,4, Balaji Narasimhan1,2,3, 1Chemical and Biological Engineering, ames, IA, USA, 2Nanovaccine institute, ames, IA, USA, 3Iowa state University, ames, IA, USA, 4Kinesiology, ames, IA, USA, 5Department of Statistics, ames, IA, USA, 6Vet Micro. Prevent. Med, ames, IA, USA  P2138

780. Co-Assembling Peptide Hydrogels for Protein Localization: Humoral Immune Response Lucas Melgar, Gregory Hudalla, Bethsymarie Soto-Morales
University of Florida, Gainesville, FL, USA   P2139

781. A Polymeric-Fentanyl Conjugate Vaccine Sandeep Kumar, PhD, Scott Wilson, PhD, Johns Hopkins University, Baltimore, MD, USA  P2140

782. Optimizing a Nanogel-Interferon Gamma Conjugate for Targeted Delivery to Macrophages Danuta Radyna1, Rana Ajeeb1, John Clegg, PhD1,2,3,4
1Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA, 2Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA, 3Harold Hamm Diabetes Center, OU Health University of Oklahoma Medical Center, Oklahoma City, OK, USA, 4Institute for Biomedical Engineering, Science, and Technology, Norman, OK, USA   P2141

783. Affinity-based Molecules for Immunomodulatory Regulation Morrhyssey Benz, Jonathan Dorogin, Madeline Martin, Marian Hettiaratchi, PhD
University of Oregon, Eugene, OR, USA   P2142

Immunomodulatory Biomaterials and Immune Cell Interfaces

784. Membrane-coated Nanoparticles for Recognition by T Cells Elizabeth Bealer, MSE1, Feiran Li, PhD1, Fanghua Li, MSE1, Russell Urie, PhD1, Eiji Saito, PhD1, Ali Turan, MS2, Esma Yolcu, PhD2, Haval Shirwan, PhD2, Lonnie Shea, PhD1, 1University of Michigan, Ann Arbor, MI, USA, 2University of Missouri, Columbia, MO, USA  P2143

785. The Role of Prostaglandin E2 Receptor Subtypes EP2 and EP4 in The Foreign Body Response to Biomaterials Brittany Thompson, MS, Emma Carillion, Stephanie Bryant, PhD, University of Colorado, Boulder, Boulder, CO, USA  P2144

786. A Molecular Level Analysis of Lipid-Composition Dependent NLRP3 Inflammasome Activation by mRNA-Lipid Nanoparticles James Forster, III, BSChE1, Dipika Nandi, PhD1,2, Ashish Kulkarni, PhD1, 1University of Massachusetts, Amherst, Amherst, MA, USA, 2Takeda Oncology, Cambridge, MA, USA   P2145

787. Magnetically-controlled alternating presentation of activation signals enhances CD8+ T cell activation capacity Xuemei Wang, MRes1, Zhaoli Gao, PhD1, Siu Hong Dexter Wong, PhD2, Liming Bian, PhD3, 1The Chinese University of Hong Kong, Shatin, NT, Hong Kong, 2The Hong Kong Polytechnic University, Hung Hom, Hong Kong, 3South China University of Technology, Guangzhou, China   P2146

788. Fibrin-laden Tumor Stroma as an Immunosuppressive Factor in Pancreatic Ductal Adenocarcinoma MAZHARUL KARIM1, MD MAHEDI HASSAN1, RIAJUL WAHAB1, JACOB HOOPER1, FARAZ BISHESHARRI, MD, PhD2, TASLIM AL-HILAL, PhD1, 1UNIVERSITY OF TEXAS EL PASO, EL PASO, TX, USA, 2RUSH UNIVERSITY MEDICAL CENTER, CHICAGO, IL, USA   P2147

Nanomaterials (SIG)

789. Manufacturing Dual Drugs Loading Liposomes Stimulated by Physical Activation Sujeong Lee, Hui Bang Cho, Hye Jin Kim, Sujin Lee, Hye-Ryoung Kim, Keun-Hong Park, CHA university, Seongnam-si,, Republic of Korea     P2148

790. Characterizing the Effects of Polymer and Surfactant Concentration on Nanoparticle Size Ryan Jones, Wade Johnson, Nisarg Shah, PhD
University of California San Diego, La Jolla, CA, USA    P2149

791. Reduction of Nanoparticle Size and Acceleration of Cell Membrane Permeability by LED Light Hui Bang Cho, Sujeong Lee, Hye Jin Kim, Sujin Lee, Hye-Ryoung Kim, Keun-Hong Park, CHA university, Seongnam-si, Republic of Korea   P2150

792. An Evaluation of DNA Replication Dynamics In Macrophages Induced By Functionalized Graphene Nanoparticles OLUWATOSIN OLADEJO1, James Bradley2, Shirali Patel1, Suridh Chakravarty1, Ananya Sangineni1, Priyadarshini Vijaykumar1, Paul Chastain1, Neeraja Revi1, Divya Bijukumar1, 1University of Illinois at Chicago, Rockford, IL, USA, 2Rockford Christian High School, Rockford, IL, USA   P2151

793. Synthesis and Characterization of Dendrimer-based Nanogels with ROS-Scavenging Activity LIN QI1, Huang Da1, Anna Chernatynskaya, Jiandong Wu, Nuran Ercal, Hu YANG, 1Missouri University of Science and Technology, Rolla, MO, USA    P2152

794. Molecular biosensing in the long-wavelength infrared with ZnO nanoparticles Lan Li, Irfan Khan, Milan Palei, Juwan Jacobe, Tracie McGinnity, Anthony Hoffman, Ryan Roeder, University of Notre Dame, notre dame, IN, USA     P2153

Orthopaedic Biomaterials (SIG)

795. Exploring the Role of Antioxidants to Minimize Implant Corrosion and Consequences Sowmya Gurusamy Kamaraj1, Hemalatha Kanniyappan1, Adriana Thayer2, Yani Sun1, Ebru Oral3, Mark Barba1, Mathew T. Mathew1, 1University of Illinois, College of Medicine, Rockford-61107, Rockford, IL, USA, 2Olivet Nazarene University, Bourbonnais, IL, USA, 3Harvard Medical School, Boston, MA, USA    P2154

796. Possible Risks of Hepatotoxicity associated with Implant: An Invitro and In vivo Study Shriya Thakur, Hemalatha Kanniyappan, Puranjay gupta, Robert Hillwig, Vedant Bodke, Salman Khetani, Mathew T.Mathew, University of Illinois, College of Medicine, Rockford-61107, Rockford, IL, USA   P2155

797. Zn-Doped Titania Nanotube Arrays with Improved Antibacterial Activity and Cell Viability Abhishek Bhattacharjee, Emma Goodall, Ketul Popat
Colorado State University, Fort Collins, CO, USA     P2156

798. Antibacterial Activity on Copper Doped Titania Nanotube Arrays Aniruddha Savargaonkar, Abhishek Bhattacharjee, Ketul Popat, PhD
Colorado State University, Fort Collins, CO, USA   P2157

799. Effects of Bioactive Glass Induced Hydroxyapatite-like Layer on Bacterial Adherence and Viability Kara Hageman, MPH1,2, Rebekah Blatt3, Richard Brow, PhD3, Terence McIff, PhD, MBA1,2, 1University of Kansas, Lawrence, KS, USA, 2University of Kansas Medical Center, Kansas City, KS, USA, 3Missouri University of Science and Technology, Rolla, MO, USA    P2158

800. Testing of Different Hydroxyapatite Particles in Cell Culture Stephany Maldonado, Gerardo Figureoa, David Gonzales, David Margolis, MD, PhD
University of Arizona, Tucson, AZ, USA    P2159

801. MMP-Responsive, Heparin-Containing Hydrogel Particles for TSG-6 Delivery to Rotator Cuff Muscle Joseph Pearson, Lauren Wilch, Johnna Temenoff
Georgia Institute of Technology/Emory University, Atlanta, GA, USA    P2160

802. Are sGAGs transferred onto the surface of hemiarthroplasty implants while rubbing against cartilage? Amandine Impergre, PhD, Markus Wimmer, PhD, Rush University Medical Center, Chicago, IL, USA    P2161

803. Biomolecule Delivery to Synergistically Mobilize and Locally Recruit Bone Marrow Cells Enhances Early Muscle Regeneration Following Rotator Cuff Tear Leah Anderson, Liane Tellier, PhD, Keshav Shah, Joseph Pearson, PhD, Edward Botchwey, PhD, Johnna Temenoff, PhD
Georgia Tech/Emory University, Atlanta, GA, USA   P2162

804. Dynamization Increases Bone Stiffness in Regenerated Bone with Polymer Scaffolds Gerardo Figueroa, David Gonzales, Evan Smith, John Szivek, PhD, David Margolis, PhD, MD, University of Arizona, Tucson, AZ, USA    P2163

805. Cathodic Activation and Inflammatory Species Alter the Corrosion Resistance of Ti-6Al-4V Oxide Michael Kurtz, BS1,2, Audrey Wessinger1,2, Lilliana Taylor1,2, Jeremy Gilbert, PhD1,2, 1Clemson University, Charleston, SC, USA, 2Medical University of South Carolina, Charleston, SC, USA   P2164

806. Synergistic effects of endocannabinoid nanoparticles and local anesthetics to reduce periarticular inflammation and pain in a rodent Osteoarthritic model Devika Kishnan, M.Sc1,2, Chung-Hao Liu1, Mu-Ping Nieh, PhD1, Joseph Walker, III, M.D2, Lakshmi Nair, PhD1,2
1University of Connecticut, Storrs, CT, USA, 2University of Connecticut Health Center, Farmington, CT, USA    P2165

807. Ti-6Al-4V Selective Dissolution is Identifiable Using Nearfield Electrochemical Impedance Spectroscopy Michael Kurtz, BS1,2, Dinghe Liu, MS1,2, Jeremy Gilbert, PhD1,2, 1Clemson University, Charleston, SC, USA, 2Medical University of South Carolina, Charleston, SC, USA   P2166

808. Surface and Antimicrobial Characterization of Silorane-Based Bone Cement Amanda Varner, BS1, Kara Hageman1, Grahmm Funk1, Elizabeth Menuey2, Kathleen Kilway2, Terence McIff1, 1University of Kansas Medical Center, Kansas City, KS, USA, 2University of Missouri Kansas City, Kansas City, MO, USA  P2167

809. Injectable, Cellulose Reinforced Osteoinductive Chitosan Hydrogels for Vertebral Compression Fractures August Hemmerla, Bret Ulery
University of Missouri - Columbia, Columbia, MO, USA  P2168

810. Compressive Properties of Ceramic Fisher-Koch-S Scaffolds for Bone Regeneration Claire Bailey, Isabella Kaze, Valerie Riegle, Erin Gunn, David Prawel, PhD, Colorado State University, Fort Collins, CO, USA    P2169

811. Processing of Fe35Mn alloy using ECAP for biomedical applications – in vitro studies Ana Paula Rosifini Alves Claro, PhD, FSBE1, Kerolene Braboza da Silva1, Fátima Raquel Maia2, Joaquim Miguel Oliveira, PhD2, 1UNESP - Sâo Paulo State University, Guaratinguetá, Brazil, 2University of Minho, Guimarães, Portugal   P2170

812. AFM Based Nanoscale Tribocorrosion on Single Region of CoCrMo alloy Hwaran Lee, MSc, Jeremy Gilbert
Clemson University, Charleston, SC, USA   P2171

813. Design and Characterization of a Functional Ti-PVA/PAAm-PVA Artificial Intervertebral Disc Xiaoyu Du1, Hossein Ansaripour1, Yijun Zhou2, Lucia Kölle1, Rafael Leon1, Cecilia Persson, PhD2, Stephen Ferguson, PhD1, 1ETH Zurich, Zurich, Switzerland, 2Uppsala University, Uppsala, Sweden  P2172

814. A Procedure for establishing Bone Materials Properties using the Cutting Mechanics Dong Min Kim, Sungwook Kang
Korea Institute of Industrial Technology, Jinju-si, Republic of Korea    P2173

815. Magnesium Phosphate Modified with 2-Hydroxyethyl Methacrylate as a Novel Representative of Dual-Setting Composite Bone Cements Marcin Wekwejt, PhD Eng1, Maryia Khamenka1, Justyna Kozłowska, PhD2, Anna Ronowska, PhD DSc3, Uwe Gbureck, Prof DSc PhD Eng4
1Gdańsk University of Technology, Gdańsk, Poland, 2Nicolaus Copernicus University, Toruń, Poland, 3Medical University of Gdańsk, Gdańsk, Poland, 4University of Würzburg, Würzburg, Germany   P2174

816. Mineralized Collagen-Chitosan Scaffolds Promote Osteogenic Potential of Rat Mesenchymal Stem Cells Sandra Stangeland-Molo1,2, Kathryn Benedict1,2, Carter Gamble1,2, Jacqueline Cole, PhD1,2, 1North Carolina State University, Raleigh, NC, USA, 2University of North Carolina- Chapel Hill, Chapel Hill, NC, USA   P2175

817. Development and Characterization of a Novel Biocompatible and Injectable Composite with Potential for Applications as the Bone-to-Implant Bonding Material Michał Bartmański, PhD1, Magda Rościszewska, MSc Eng1, Marcin Wekwejt, PhD1, Anna Ronowska, DSc PhD2, Aleksandra Mielewczyk-Gryń, DSc PhD1, Małgorzata Nadolska-Dawidowska, MSc Eng1, Niko Moritz, DSc PhD3, 1Gdańsk University of Technology, Gdańsk, Poland, 2Medical University of Gdańsk, Gdańsk, Poland, 3University of Turku, Turku, Finland    P2176

818. Quantifying Fatigue Fracture Surfaces for UHMWPE Composites Abigail Chase, Peder Solberg, Rebecca Thomson, Douglas Van Citters, PhD
Dartmouth College, Hanover, NH, USA    P2177

Stimuli-Responsive Biomaterials

819. Cellular Traction Force-Mediated Delivery of Biologics Modulates Angiogenesis In Vitro and In Vivo During Tissue Repair Madgalene Ho, Nuria Oliva, PhD, Christopher Basu, PhD, Benjamin Almquist, PhD, Imperial College London, London, United Kingdom   P2178

820. Synthetic Scaffolds as Matrices for 3D induced Pluripotent Stem Cell Culture Luis Arrieta-Viana, Madeline Torres-Lugo, PhD
University of Puerto Rico at Mayagüez, Mayaguez, Puerto Rico P2179

821. Tumor-targeting Prooxidant Prodrug Nanoparticles as Immunogenic Cell Death-inducing Anticancer Nanomedicine Nanhee Song, Seungwon Jeong, Hanui Jo, Manseok Yang, Dongwon Lee, Jeonbuk National University, Jeonju-si, Republic of Korea P2180

822. SnAg impedance behavior in physiological solution Charley Goodwin1,2, Jeremy Gilbert, PhD1,2, 1Medical University of South Carolina, Charleston, SC, USA, 2Clemson University, Clemson, SC, USA P2181

824. Enzyme Responsive Polymersomes as a Pathology-Driven Treatment for Neurologic Lysosomal Storage Disease Dorian Foster, BS, Alaura Cakely, Jessica Larsen, Clemson University, Clemson, SC, USA   P2182

825. Thermally Responsive Hydrogels for In-Situ Application Post-Brain Tumor Resection Molli Garifo, Jessica Larsen, PhD
Clemson University, Clemson, SC, USA   P2183

826. Engineering of Degradable Linkers to Improve Oxidative Sensitivity of Thioketal-Based Biomaterials Karina Bruce, Dylan Marques, Alan Fullenkamp, John Martin, PhD, University of Cincinnati, Cincinnati, OH, USA   P2184

827. Creation of dual-stage, ROS-responsive microparticles for drug delivery to critically-sized bone defects Dylan Marques, Allen Fullenkamp, John Martin
University of Cincinnati, Cincinnati, OH, USA    P2185

828. Bioprinted Hybrid PCL/PVDF/DBM Piezoelectric Scaffolds for Bone Tissue Engineering Applications Damion Dixon, Erika Landree, Cheryl Gomillion, PhD, University of Georgia, Athens, GA, USA   P2186

829. In vitro release kinetics of bupivacaine and trans-2-decenoic acid from electrospun chitosan membranes with direct acylation of 2-decenoic acid Jermiah Tate, Ezzuddin Abuhussein, Jessica-Amber Jennings, PhD, Joel Bumgardner, PhD, Tomoko Fujiwara, PhD, Daniel Baker, PhD, Brenna Ballard, University of Memphis, Memphis, TN, USA   P2187

830. Stimuli-responsive Cyanobacteria Biocomposite Hydrogels with Complex Phenotypes for Bioremediation Debika Datta1, Elliot Weiss1,2, James Golden1, Susan Golden1, Jonathan Pokorski1, 1University of California San Diego,, La Jolla, CA, USA, 2Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA    P2188

 

Poster Session III - Friday, April 21st, 3:30 PM - 5:00 PM

Biofunctionalized Biomaterial Surfaces for Cellular and Tissue Engineering

831. Dual drug delivery via multiscale structures fabricated on open-cell porous 3D printed neovius scaffold for osteosarcoma management Sonu Singh1, Rahul Roy1, Priya Vashisth1, Dinesh Kalyanasundaram1,2, 1Indian Institute of Technology Delhi, New Delhi, India, 2All India Institute of Medical Sciences, New Delhi, India   P3001

832. Multi-functional bioinspired coating for enhanced self-lubrication and bacterial resistance Di SUO, The Hong Kong Polytechnic University, Hung Hom, Hong Kong   P3002

833. Vertically-Aligned Dipeptide Nanotube Arrays as a Substrate for Neural Cell Differentiation,
Jordan Pagliuca, Alecsander Da Silva, Milana Vasudev, PhD, University of Massachusetts Dartmouth, Dartmouth, MA, USA  P3003

834. Monodisperse Elastomeric Particle Jamming for Use in Self-Healing Biomaterials Jennifer Kieda, MASc, Kaitlyn Ramsay, PhD, Richard Jiang, Milica Radisic, PhD, University of Toronto/Toronto General Hospital Research Institute, Toronto, ON, Canada
Hoai-Thuong Bui, Wei Mao, PhD, Miso Lee, Wanho Cho, Lan Pham, Hyuk Sang Yoo, PhD, Kangwon National University, Chuncheon-si, Republic of Korea  P3004

835. Synthesis of Photo-Crosslinkable Hyaluronan Based Nanofibrous Structure for Enhancing Mechanical Property of Cells-Nanofibrils Complex Hoai-Thuong Bui, Wei Mao, PhD, Miso Lee, Wanho Cho, Lan Pham, Hyuk Sang Yoo, PhD, Kangwon National University, Chuncheon-si, Republic of Korea   P3005

836. Cell-Specific Impacts of Surface Coating Composition on Extracellular Vesicle Secretion Yuan Liu, Christina Holmes, Florida A&M University-Florida State University College of Engineering, Tallahassee, FL, USA  P3006

837. Studying Interactions Between PEI-DNA Polyplexes and Polymer Surface Coatings for Localized Sailesti Joshi, Sydney Hall, Christina Holmes, PhD
Florida A&M University-Florida State University College of Engineering, Tallahassee, FL, USA   P3007

Biomaterial-Associated Infection: Focusing on the Biomaterial, Host, Pathogen, or All?

838. Janus-type Dressings for Effective Delivery of Antimicrobial Peptide/Agents to Treat Wound Biofilms YAJUAN SU, PhD, JINGWEI XIE, Professor, GUANGSHUN WANG, Professor, University of Nebraska Medical Center, Omaha, NE, USA   P3008

839. Biofilm Elimination Using Self-locomotive, Antimicrobial Microrobots (SLAM) Joo Hun Lee, Yu-Heng Deng, Hyunjoon Kong
University of Illinois at Urbana Champaign, Urbana, IL, USA    P3009

840. Poly(arginine) and Hyaluronic Acid Multimodal Coating of Hernia Meshes with Antimicrobial Properties
Cynthia Calligaro1, Mehdi Daoudi2, Madjid Tagzirt3, Nihal Vrana1
1Spartha Medical, Strasbourg, France, 2COUSIN Surgery (Biotech), Wervicq-Sud, France, 3INSERM U1011, Lille, France   P3010

841. A predictive chemoinformatic model for discovering new persister control agents Dacheng Ren, PhD, Zeynep Cakmak, Sweta Roy
Syracuse University, Syracuse, NY, USA   P3011

842. Chitosan-Based Formulations for Controlling the Hospital-Acquired Infections in a Public Setting Sushant Sawant, Mikhail Bredikhin, Alexey Vertegel, PhD, Clemson University, Clemson, SC, USA   P3012

843. Antibacterial Treatments on the Surface of Novel Beta Metastable Titanium Alloys
Fernanda Quadros, Gerson Almeida, Pedro Kuroda, PhD, Willian Zambuzzi, PhD, Carlos Grandini, PhD, FBSE
UNESP - Univ. Estadual Paulista, Bauru, Brazil     P3013

844. Incorporation of Silver Salts within a Transcutaneous Biosensor for Infection Control
Jonathan McCanless, PhD1, Jessica Jennings, PhD2, Benjamin Feldman, PhD1, 1Abbott Diabetes Care, Inc, Alameda, CA, USA, 2The University of Memphis, Memphis, TN, USA   P3014

845. Nitric Oxide and Bacteriophages as Combined Antibacterial Agents to Counter Drug-Resistant Infections Sarah Wilson, Vijay Gondil, PhD1, Elizabeth Brisbois, PhD1, Hitesh Handa, PhD1, 1University of Georgia, Athens, GA, USA    P3015

846. Preclinical performance testing of medical devices with antimicrobial effects
J. Alex Chediak, Ph.D.1,2, Hao Wang, PhD2, K. Scott Phillips, PhD2, Philip Belmont, Jr., PhD2, David Saylor, PhD2
1California Baptist University, Riverside, CA, USA, 2Food and Drug Administration, Silver Spring, MD, USA    P3016

Biomaterial-Based in Vitro Cancer/Tumor Models for Drug Screening and Diagnostics

847. Novel Diagnostic Tool for Battling Breast Cancer: Urine-based Biosensor (iBiosensC) with Aritifical Intelligence Model
SAUNDARYA PRITHWEERAJ, Masters, Mathew Mathew, PhD, Hemalatha Kanniyappan
University of Illinois, College of Medicine, Rockford-61107, Rockford, IL, USA     P3017

848. 3D In Vitro Model of Osteosarcoma Rameshwar Rao, MD PhD1, Briana Villa-Martin2, Sarah Heilshorn, PhD2, 1Stanford School of Medicine, Stanford, CA, USA, 2Stanford University, Stanford, CA, USA   P3018

849. Investigating Ovarian Cancer Spheroids as Improved in vitro Models of Inherent Chemoresistance Amanda Murray, Kharimat Alatise, Angela Alexander-Bryant, PhD, Clemson University, Clemson, SC, USA    P3019

851. Cancer cell character alteration cultured in a novel collagen microfiber with high dispersibility could be retained after the removal of scaffold Asuka Kato1,2, Shiro Kitano1,2, Michiya Matsusaki2,3, 1TOPPAN INC., TOPPAN Technical Research Institute, Saitama, Japan, 2Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan, 3Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan   P3021

852. 3D Printable Phantom for Mimicking Electrical Properties of Dermal Tissue, Blake Kuzemchak1,2, Robert Choe1,2, Mary Sherry1,2, Emily Porter3, John Fisher1,2, 1Univeristy of Maryland College Park, College Park, MD, USA, 2Center for Engineering Complex Tissues, College Park, MD, USA, 3University of Texas at Austin, Austin, TX, USA   P3022

853. Evaluating the Effect of Radiation on Vessel Formation in an in-vitro Vascularized Glioblastoma Model, Yoanna Ivanova, Mai Ngo, PhD, Kimberly Selting, DVM, Brendan Harley, ScD, University of Illinois at Urbana Champaign, Urbana, IL, USA   P3023

855. 3D in vitro bone-mimetic testbed for screening phenolic compounds against bone metastatic breast cancer Preetham Ravi, Haneesh Jasuja, Dipayan Sarkar, Dinesh Katti, Kalidas Shetty, Kalpana Katti, North Dakota State University, Fargo, ND, USA   P3025

856. Validating Three-Dimensional Hydrogel Models of Glioblastoma for Discovery of Novel Therapeutics, Viktoriia Kriuchkovskaia1, Brendan Harley, ScD1, Rebecca Riggins, PhD2, 11University of Illinois Urbana-Champaign, Urbana, IL, USA, 2Georgetown University, Washington, DC, USA   P3026

857. Biomaterial Optimization for Cell Separation in Wicking Fiber Bundles Courtney Long, Weitong Chen, Kelsey Collins, Timothy Burg, Karen Burg, University of Georgia, Athens, GA, USA    P3027

858. Development of a Biocompatible UV-Curing Polymer and 3D Microfluidic Electroporators Guigen Zhang, PhD, University of Kentucky, Lexington, KY, USA   P3028

Biomaterials and Medical Products Commercialization (SIG)

859. Laser Fabricated Barbed Suture for Wound Closures during Plastic Surgery, Karuna Nambi Gowri, PhD1, Martin King, PhD1, Roger Narayan, PhD2, Gregory Ruff, MD1, 1Wilson College of Textiles, North Carolina State University, Raleigh, NC, USA, 2North Carolina State University, Raleigh, NC, USA  P3029

860. Characterization and Comparison of Dipropylhexanediamine Incorporated Nitric Oxide Releasing Medical Grade Polymers with Varying Water Uptakes Patrick Maffe, Mark Garren, Manjyot Kaur Chug, Lori Estes Bright, Hitesh Handa, Elizabeth Brisbois, University of Georgia, Athens, GA, USA   P3030

861. Designing Wearable Nitric Oxide Releasing Catheter Insert via Covalently Immobilized S-Nitroso-N-acetylpenicillamine (SNAP) for Preventing Bacterial Infection, Manjyot Kaur Chug, PhD, Aasma Sapkota, Mark Garren, Hitesh Handa, PhD, Elizabeth J. Brisbois, PhD
University of Georgia, Athens, GA, USA   P3031

862. Inclusion Complexation of S-Nitrosoglutathione for Sustained Nitric Oxide Release from Catheters: A Strategy to Prevent and Treat Device-Associated Infections Xuewei Wang, Wuwei Li, Danyang Wang, Ka Un Lao, Virginia Commonwealth University, Richmond, VA, USA   P3032

863. Nanocellulose Based Foams for Low-Cost Disposable Medical Applications, Dominic Kugell, B.S., Spencer Johndro, Sydney Sheehan, Michael Mason, PhD, University of Maine, Orono, ME, USA   P3033

864. Hydrophobic Interaction Chromatography of Hair Protein Biomaterials Megan Forst, Roche de Guzman, PhD, Hofstra University, Hempstead, NY, USA    P3034

865. Comparative Degradation Profiles of Glycoprene® 935 and Vicryl® Warp Knit Mesh, K. Bethany Acampora, PhD, Julien Boyon, PhD, Sydney Nuckles, M. Scott Taylor, PhD, Seth McCullen, PhD, Poly-Med, Inc., Anderson, SC, USA    P3035

866. Resorbable Dental Membranes with Improved Chair-side Handling Properties Jian-Feng Zhang, PhD1, Donghun Koo, PhD1, Scott Jones, MBA1, Mahrokh Dadsetan, PhD1, Theresia Kuntz, PhD2, 1Evonik Corporation, Birmingham, AL, USA, 2Evonik Operations GmbH, Darmstadt, Germany  P3036

867. Bioactive Bioresorbable Implant for Tibial Tuberosity Advancement in Dogs: Preliminary Results of a Clinical Trial
Julia Kulkova, DDS, PhD1, Gareth Arthurs, PGCertMedEd MA VetMB CertVR CertSAS DSAS(Orth) FHEA FRCVS RCVS2, Niko Moritz, PhD1
1University of Turku, Turku, Finland, 2University of Nottingham School of Veterinary Medicine and Science, Stanford, Sutton Bonington, United Kingdom   P3037

Biomaterials for Modeling the Heart to Study Disease and Therapies in Vitro

868. Micropatterned hiPSC-CMs for disease modeling of hypertrophic cardiomyopathies Huaxiao Yang, PhD, Dovile Strimaityte, Nick Rogozinski, Isha Murugesan, University of North Texas, Denton, TX, USA   P3038

869. Conductive Scaffolds to Mature Induced Pluripotent Stem Cell-Derived Cardiomyocytes Suh Hee Cook, Jack Twiddy, Michael Daniele, PhD, Jessica Gluck, PhD, North Carolina State University, Raleigh, NC, USA   P3039

870. Development of functional cardiac organoids in a synthetic hydrogel system Yuanhui Song, Zhen Ma, Syracuse University   P3040

871. Oxygen-generating microparticles increase cardiac contractility, downregulate HIF-1α expression, and mitigate ischemic injury Kalpana Mandal, vadim Jucaud, Mehmet Dokmeci, Ali KhademhosseiniTearasaki Institute for Biomedical Innovation, Los Angeles, CA, USA  P3041

Biophysical Strategies for Regulation of Cellular Microenvironments

872. Blue-Light Mediated Photobiomodulation Induces Enhanced Osteogenesis in Saos-2 Cells Maria Albaqami1, Ayda Pourmostafa2, Margaret Ahmad3, Vipuil Kishore1, 1Florida Institute of Technology, Melbourne, FL, USA, 2New Jersey Institute of Technology, Newark, NJ, USA, 3Sorbonne University, Paris, France     P3042

873. Micromagnetic hydrogels to generate dynamic and reversible tissue folding patterns in vitro Avinava Roy, Zenghao Zhang, Alan Shi, Abdon Pena-Francesch, PhD, Claudia Loebel, MD, PhD, University of Michigan, Ann Arbor, MI, USA    P3043

874. Using magnetic fields to control fiber alignment within static and dynamic hydrogels Grace Schwarz, Greg Jensen, Julianne Holloway
Arizona State University, Tempe, AZ, USA   P3044

Cancer Immunotherapy

875. A Metabolic Labeling Approach for Developing Enhanced Tumor Exosome Vaccines Rimsha Bhatta, University of Illinois at Urbana Champaign, Urbana, IL, USA   P3045

876. Cancer immunotherapy by in vivo delivery of Cas9 conjugate nanocomplex Juhee Lee1, Yoo Kyung Kang1, Eonju Oh2, Keehoon Jung2, Hyun Jung Chung1, 1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2Department of Anatomy and Cell Biology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea   P3046

877. Poly I:C Lipid Nanoparticle for Anti-Tumor Efficacy in Head and Neck Cancer Vidit Singh, Anna Chernaynskaya, Lavanya Bhargava, Tristan Cole, Hu Yang, PhD, Missouri University of Science and Technology, Rolla, MO, USA     P3047

878. Biomaterial Niches for Modulating Anti-Tumor CD8+ T Cell Metabolism Joseph Choy, Yicheng Zhang, Natalie Livingston, Chenhu Qiu, Jonathan Schneck, Hai-Quan Mao, Johns Hopkins University, Baltimore, MD, USA     P3048

879. Nanoparticle-based Chimeric Antigen Receptor T Cell Therapy Ting-Yu Shih, PhD, Kareen Fajardo Cortes, Yuyang Gu, Sarah Adams, Eric Bressler, Wilson Wong, PhD, Mark Grinstaff, PhD, Boston University, Boston, MA, USA    P3049

880. Tumor-localizing nanoparticles for delivery of immunomodulatory protein drugs Yuyang Gu, Ting-Yu Shih, Wilson Wong, Mark Grinstaff
Boston University, Boston, MA, USA    P3050

881. Degradable Microscaffold Removal for Improving Therapeutic T Cell Quality Miguel Armenta Ochoa1,2, Nathan Dwarshuis, PhD1,2, Krishnendu Roy1,2,3, 1Georgia Institute of Technology and Emory University, Atlanta, GA, USA, 2NSF Engineering Research Center for Cell Manufacturing Technologies (CMaT), Atlanta, GA, USA, 3Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M), Atlanta, GA, USA   P3051

882. Engineering PBAE Nanoparticles for Delivery of Immunological Signals into Meningioma Cancer Cells Joanna Yang
Johns Hopkins University, Baltimore, MD, USA    P3052

883. A Facile Metabolic Labeling Approach for Developing Enhanced Dendritic Cell Vaccines Joonsu Han, Rimsha Bhatta, Hua Wang
University of Illinois at Urbana Champaign, Champaign, IL, USA   P3053

Cardiovascular Biomaterials (SIG)

884. A Natural Biomaterial Scaffold for Heart Valve Tissue Engineering, Jessica Perez, MSc1,2
1Technological University Dublin, Dublin, Ireland, 2RCSI University of Medicine and Health Sciences, Dublin, Ireland    P3054

885. 3D Printed Vascular Grafts with Ionic Dissolution Product Delivery and Heparin Release for Rapid Endothelialization, Shangsi Chen, Liwu Zheng, Min Wang, The University of Hong Kong   P3055

886. Engineered Antithrombogenic Completely Biological Small-Diameter Acellular Vascular Grafts, Weilue He, YehChia Tseng, Eric Wang, Rachael Bischof, Roger Guillory, Jeremy Goldman, Feng Zhao, Michigan Technological Univeristy, Texas A&M University      P3056

887. Sustainable Synthetic Polymer for a more Hemocompatible and Durable Prosthetic Aortic Valve, Sofia Melo1, Anna Pierrard2, Abdelhafid Aqil2, Bartosz Ditkowski1, Christophe Detrembleur2, Christine Jérôme2, Patrizio Lancellotti1,3,4, Cécile Oury1, 1GIGA-University of Liège, Liège, Belgium, 2CERM-University of Liège, Liège, Belgium, 3University Hospital (CHU) of Liège, Liège, Belgium, 4GVM - Anthea Hospital, Bari, Italy    P3057

888. Injectable Cardiac Extracellular Matrix-derived Nanocomposite Hydrogel as Sustained Release System with Stromal Cell-derived Factor-1α for Cardiac Regeneration, Jiazhu Xu1, Rubia Shaik2, Luis Soto-Garcia1, Alan Taylor1, Huikang Fu1, Kytai Nguyen, Jun Liao1, Ge Zhang2, Yi Hong1, 1University of Texas at Arlington, Arlington, TX, USA, 2The University of Akron, Akron, OH, USA    P3058

889. Development of a Novel Drug-Loaded Fibrin-Based Nanoparticle Biomaterial for Improved Surgical Wound Healing, Nina Moiseiwitsch, BS, Nicole Zwennes, Ashley Brown, PhD, North Carolina State University, Raleigh, NC, USA   P3059

890. Use of Contact Activation Inhibitors to Improve Thrombosis Outcomes on Nitinol Stents, Deirdre Anderson, PhD1, Novella Bates, PhD1, Michael Wallisch, PhD1,2, Jennifer Johnson1, Helen Vu1, Kelley Jordan1, Erik Tucker, PhD1,2, Khanh Nguyen, MD1, Owen McCarty, PhD1, Joseph Aslan, PhD1, Monica Hinds, PhD1, 1Oregon Health & Science University, Portland, OR, USA, 2Aronora, Inc, Portland, OR, USA   P3060

891. Registration of Atomic Force Microscopy and Second Harmonic Generation Images for Biomechanical Property Study of Myocardiu, Adam Baker, Zhi Gao, PhD, Reece Fratus, Lucas Schmidt, PhD, Tom Borg, PhD, Clemson University, Clemson, SC, USA   P3061

892. Hierarchically Structured, Lubricant Infused, Flexible Substrates Prevent Biological Surface Fouling Under Static and Dynamic Conditions, Shadman Khan, Noor Abu Jarad, Liane Ladouceur, Kenneth Rachwaiski, Veronica Bot, Amid Shakeri, Roderick Maclachlan, Sadman Sakib, Jeffrey Weitz, Eric Brown, Leyla Soleymani, Tohid Didar, McMaster University   P3062

Cardiovascular Manufacturing

893. Vasculogenesis in Particle-based Gels, Natasha Claxton, Melissa Luse, Brant Isakson, PhD, Christopher Highley, PhD, University of Virginia, Charlottesville, VA, USA   P3063

894. 3D Stereolithography printed self-driven microfluidic platform for dynamic culture of Cardiovascular tissue models, Sylvia Natividad-Diaz, Ph.D., Binata Joddar, Ph.D., Aibhlin Esparza, Nicole Jimenez, The University of Texas at El Paso, El Paso, TX, USA  P3064

Cell Encapsulation and Digital Assembly for Basic and Applied Biomedicine

895. Deep Learning-enabled Label-free On-chip Detection and Selective Extraction of Cell Aggregate-laden Hydrogel Microcapsules, Alisa White, MS, Xiaoming He, PhD, University of Maryland, College Park, MD, USA   P3065

896. Encapsulation of Living Cells Using Ice Templating: Towards the Cryopreservation of Red Blood Cells in Absence of Toxic Cryoprotectants, Francisco Fernandes, PhD, HDR, Kankan Qin, PhD, Christophe Hélary, PhD, Sorbonne University, Paris, France   P3066

897. Culturing Primary Hepatocytes in Glycosaminoglycan-Based Capsules: Interior ECM Components Promote Hepatic Organization and Function. Rafael Ramos, MS1,2, Howard Matthew, PhD1, 1Wayne State University, Detroit, MI, USA, 2Wayne State University School of Medicine, Detroit, MI, USA  P3067

898. Characterization of PEG Hydrogel Properties and the Effect of Ligands on Chondrogenesis for Articular Cartilage Tissue Formation, Luiza DaMotta, University of Michigan, Ann Arbor, MI, USA  P3068

Development of Novel Bioinks for Tissue Engineering

899. Independently Tuning Mechanical Properties and Scaffold Architecture by 3D Printing with Different Polymer Molecular Weights, John Tolbert1, Tyler French1, Chiebuka Okpara1, Santiago Lazarte2, Brandon Krick, PhD2, Tomas Gonzalez-Fernandez, PhD1, Lesley Chow, PhD1, 1Lehigh University, Bethlehem, PA, USA, 2Florida A&M University-Florida State University, Tallahassee, FL, USA    P3069

900. Development of an Angiogenic Bioink for 3D Bioprinting of a Bone Substitute, Shervin Ilanlou, M.Sc., Eric Lehoux, Ph.D., Isabelle Catelas, Ph.D., P.Eng., FIOR, University of Ottawa, Ottawa, ON, Canada  P3070

901. Overpacked Microgel Dispersions as Printable Colloidal Pastes, Andrew Lyon, PhD1, Sanika Pandit2, Anne Marie Santich1, 1Chapman University, Orange, CA, USA, 2North Carolina State University, Raleigh, NC, USA    P3071

902. Reinforced Gelatin-Methacrylate Hydrogels Containing Poly(lactic-co-glycolic acid) Nanofiber Fragments for 3D Biopriniting, Young-Gwang Ko, PhD1, Oh Hyeong Kwon, PhD, 1Kumoh National Institute of Technology, Gumi, Republic of Korea    P3072

Drug Delivery (SIG)

903. Injectable Hydrogel Rod for Long-term Anti-angiogenic Protein Delivery to the Retina, Simin Lee, PhD1, Jae Shin Song, MD2, Hye Kyoung Hong, PhD2, Se Joon Woo, PhD2, Ki Dong Park, PhD1, 1Ajou University, Suwon, Republic of Korea, 2Seoul National University Bundang Hospital, Seongnam, Republic of Korea     P3073

904. Effective mRNA delivery by condensation with cationic nanogels incorporated into liposomes, San Hae Im, Juhee Lee, Hyun Jung Chung, Nevena Duskunovic, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea   P3074

905. mRNA delivery based on linker-stabilized lipid nanoparticles, San Hae Im, Hyun Jung Chung, KAIST (Korea Advanced Institute of Science and Technology), Daejeon, Republic of Korea  P3075

906. Cas9 Conjugates for Target-Specific Delivery and Gene Editing in Cancer Cells, Seungju Yang, Hyun Jung Chung, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea    P3076

907. Engineering Injectable Hydrogels with Programmable Vaccine Release Kinetics, Wenting Shi, Xi Ying, M.G. Finn, PhD, Georgia Institute of Technology, Atlanta, GA, USA     P3077

908. Development of Cartilage Penetrating Dendrimer for Osteoarthritis Treatment, Joon Ho Park, PhD1,2, Brandon Johnston1,2, Simone Douglas-Green, PhD1,2, Alan Grodzinsky, PhD1, Paula Hammond, PhD1,2, 1Massachusetts Institute of Technology, Cambridge, MA, USA, 2Koch Institute for Integrative Cancer Research, Cambridge, MA, USA    P3078

909. uPA- or ACPP-mediated Polyamidoamine Dendrimer-based Targeted Drug Delivery System for Triple Negative Breast Cancer, Hsin-Yin Chuang, MS, Da Huang, PhD, Yue-Wern Huang, PhD, Hu Yang, PhD, Missouri University of Science and Technology, Rolla, MO, USA  P3079

910. Novel Nanocapsule Drug Delivery Vehicle to Selectively Target Islet β-Cells. Jillian Collins1, Keifer Holcomb1, Ali Shilleh2, Holger Russ, PhD2, Nikki Farnsworth, PhD1, 1Colorado School of Mines, Golden, CO, USA, 2Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA  P3080

911. Engineering Desolvated Protein Nanoparticles for Increased Endosomal Escape of Protein Therapeutics, Sydney Wimberley, Julie Champion, PhD, Georgia Institute of Technology, Atlanta, GA, USA   P3081

912. Investigating carrier degradation and drug release mechanisms of metal-organic framework nanoparticles, Mai Vuong1,2,3, Benedikt Lassalle-Kaiser4, Mathieu Frégnaux1, Anne-Laure Rollet3, Charlotte Martineau-Corcos1, Ruxandra Gref2, Mohamed Haouas1, 1Institut Lavoisier de Versailles, UVSQ, Université Paris-Saclay, Versailles, France, 2Institut des Sciences Moléculaires d'Orsay, Université Paris-Saclay, Orsay, France, 3Laboratoire Physico-Chimie des Électrolytes et Nano-Systèmes Interfaciaux (PHENIX), Sorbonne Université, Paris, France, 4Synchrotron SOLEIL, Gif-sur-Yvette, France   P3082

913. Preparation and evaluation of an in-situ forming, intratumorally injectable, click-cross-linked hyaluronic acid hydrogel depot, Hyeon Jin Ju, Moon Suk Kim, Ajou University, Suwon, Republic of Korea    P3083

914. Pirfenidone delivery from Biocompatible Nanoparticle Hydrogel Emulsions for attenuation of joint inflammation and fibrosis, Meghan Moran, PhD1, Georgia Papavasiliou, PhD2, Anna Plaas, PhD1, Rayan Abdulhadi2, 1Rush University, Chicago, IL, USA, 2Illinois institute of Technology, Chicago, IL, USA   P3084

915. Drug delivery from complex coacervate encapsulated in layered microneedles, Nathaniel Wright, Tim Wu, Yadong Wang, Cornell University, Ithaca, NY, USA   P3085

916. Utilizing Thiolyne Click Chemistry to Target Cancer-Associated Cells Using Folate-Conjugated Liposomes, Tanzeel Rehman, Kaitlin Bratlie, PhD, Surya Mallapragada, PhD, Iowa State University, Ames, IA, USA   P3086

917. Evaluating the Synergistic Effect of Various Ibuprofen Concentrations in Combination with Doxorubicin-Loaded Liposomes to Target Tumor-Associated Macrophages. Tanzeel Rehman, Kaitlin Bratlie, PhD, Surya Mallapragada, PhD, Iowa State University, Ames, IA, USA  P3087

918. Coacervate-filled Lipid Vesicles for Protein Delivery, Chia-Wei Yeh, MS, Yadong Wang, PhD, Cornell University, Ithaca, NY, USA  P3088

919. Loading Fluorescent Nanoparticles for an Improved Microbubble Theranostic, Matthew Shirley, MS, Margaret Wheatley, PhD, Drexel University, Philadelphia, PA, USA   P3089

Drug Delivery for Cardiovascular Applications

920. Dendrimer-based Nanoparticles for Atherosclerosis Diagnosis and Therapy, Huari Kou, MS, Anna Chernatynskaya, MS, Jiandong Wu, PhD, Hu Yang, PhD, Missouri University of Science and Technology, Rolla, MO, USA   P3090

921. Controlled β-Aminopropionitrile using Electrospun Nanofibers Alters Matrisome Gene Expression and Promotes a Contractile Smooth Muscle Cell Phenotype in Rat Fistulas, Brandon Applewhite1, Miguel Rojas2, Yuntao Wei, MD2, Fotios Andreopoulos, PhD1,2, Roberto Vazquez-Padron, PhD2
1University of Miami, Coral Gables, FL, USA, 2University of Miami Miller School of Medicine, Miami, FL, USA   P3091

923. A First Principles Approach to Drug-Polymer Solution Formulation for Controlled Release, Ejaz Haque, PhD, Jorge Jimenez, PhD, Zachary Hales, Brendan Laine, BD Medical, Salt Lake City, UT, USA   P3092

Engineering the Extracellular Matrix

924. Shear induced collagen fibril alignment using FRESH 3D bioprinting, Neeha Dev Arun, MS, Adam Feinberg, PhD, Carnegie Mellon University, Pittsburgh, PA, USA   P3093

925. Creation of 3D collagen substrate with curved shapes and controlled fiber alignment, mehran mansouri, M.Sc., Indranil Joshi, M.Sc., Madeleine Goulet, Ann Byerley, Vinay Abhyankar, PhD, Rochester Institute of Technology, Rochester, NY, USA   P3094

927. Systematic evaluation of gelatin bloom strength on gelatin methacryloyl hydrogel properties, Samantha Zambuto, PhD1, Eya Ferchichi2, Silviya Zustiak, PhD2, Michelle Oyen, PhD1, 1Washington University in St. Louis, St Louis, MO, USA, 2Saint Louis University, St Louis, MO, USA  P3096

Host Response to Biomaterials/Macrophage Plasticity at Tissue-Biomaterial Interface

928. Potential Modulation of Tissue Repair via M2 Macrophage Subtypes In Vitro For Applications in Treatment of Stress Urinary Incontinence, Ilaha Isali, Phillip McClellan, Thomas R. Wong, Sara Hijaz, David Fletcher, Tracey L. Bonfield, James M. Anderson, Adonis Hijaz, Ozan Akkus, Case Western Reserve University, Cleveland, OH, USA    P3097

929. Regulation of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 via M2 Macrophage-Seeded Collagen Mesh, Ilaha Isali, MD, Phillip McClellan, PhD, Thomas Wong, James Anderson, MD, PhD, Ozan Akkus, PhD, Adonis Hijaz, MD, Case Western Reserve University, Cleveland, OH, USA   P3098

930. Development of Exosome encapsulated Sulforaphane for homotypic targeting of macrophages. Shirali Patel, Suridh Chakravarty, Neeraja Revi, Divya Rani Bijukumar University Of Illinois, Rockford, IL, USA     P3099

931. Immunometabolism and polylactide stereochemistry: reconciling a decades-long controversy, Chima Maduka, DVM, MS, PhD, Christopher Contag, PhD, Michigan State University, East Lansing, MI, USA    P3100

932. High-Throughput Phenotypic Image Analysis of Porous Precision-Templated Scaffold Resident Cells, Nathan Chan, Billanna Hwang, MPH, DHSc, James Bryers, PhD, University of Washington, Seattle, WA, USA    P3101

933. PVC Tubing Results in Monocytic Insult on Neonatal Endothelial Cells: Role of Shear Stress. Hao Zhou, MS1, Lan Tu, PhD2, Vishal Nigam, MD2, Cecilia Giachelli, PhD1, Marta Scatena, PhD1, 1University of Washington, Seattle, Seattle, WA, USA, 2Seattle Children's, Seattle, WA, USA  P3102

934. Comparison of the host response to Bard Soft Mesh and GalaFLEX Surgical Scaffold, Marrisa Therriault, Mangesh Kulkarni, Clint Skillen, Bryan Brown, Department of Bioengineering, McGowan Institute for Regenerative Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute   P3103

935. Cytocompatibility of Electrospun Chitosan Membranes Treated with Decanoic Anhydride and Loaded with Biofilm Inhibitors and Bupivacaine, Yogita Dintakurthi, Tibirni Yusuf, Zoe Harrison, PhD, Emily Montgomery, Amber Jennings, PhD, The University of Memphis, Memphis, TN, USA    P3104

Immunomodulation and Cancer Imaging and Therapy using Nanomaterials

936. Nitrodopamine PEGylated iron Oxide Nanostars as therapeutic agents to treat cancer via magneto-mechanical actuation, John Cooper, Graduate student1, Mohammad kanber, Grad student, Robert Moller, Juan Beltran-Huarac, Professor, 1East Carolina University, Greenville, NC, USA  P3105

938. Light and immunostimulant mediated in-situ re-education of tumor-associated macrophages by photosensitizer conjugated mannan nanoparticles for boosting immuno-photodynamic anti-metastasis therapy, In-Kyu Park, PhD1, Saji Uthaman2, Shameer Pillarisetti1, 1Chonnam National University, Hwasun, Republic of Korea, 2Chungnam National University, Daejeon, Republic of Korea   P3107

939. CT Imaging of Gold-Loaded Polymersomes to Detect Glioblastoma, Isabel Ray, Joseph LaValla, Emily Barnett, Vaishnavi Kanduri, Jasmine White, Angela Alexander-Bryant, PhD, Jessica Larsen, PhD Clemson University, Clemson, SC, USA  P3108

Incorporating Trained Immunity Concepts in Biomaterial Design

941. Measuring Temporal Dynamics of Macrophage Polarization Using Bioluminescence to Determine Nanotherapeutic Efficacy, Colette Bilynsky, Chloe Brown, Elizabeth Wayne, PhD, Carnegie Mellon University, Pittsburgh, PA, USA   P3109

New materials and Approaches to Enhance Current Cardiovascular Devices

942. A New Nanomembrane Strain Sensor Embedded Coronary Stent to Monitor In-Stent Restenosis, Moataz Elsisy, PhD1, Robert Herbert2, Woon-Hong Yeo, PhD2, Youngjae Chun, PhD3, 1Cairo University, Giza, Egypt, 2Georgia Institute of Technology, Atlanta, GA, USA, 3University of Pittsburgh, Pittsburgh, PA, USA     P3110

943. Comprehensive Mechanical Performance Analysis of New Ultra-Thin Cobalt Chromium Coronary Stents. Mohamed Ibrahim, MS1, Moataz Elsisy, PhD2, Kara Nghiem1, Chang Hun Kum3, Jae Hwa Cho3, Gyuhyun Jin3, Sang Hyun An, PhD4, Youngjae Chun, PhD1, 1University of Pittsburgh, Pittsburgh, PA, USA, 2Cairo University, Giza, Egypt, 3OSSTEM CARDIOTEC Co., Ltd, Seoul, Republic of Korea, 4Daegu Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea     P3111

944. A Surveillance System of Blood Flow for Vascular Grafts Using Textile Technologies, Xiaoqi Tang1, Martin King, PhD1,2, 1North Carolina State University, Raleigh, NC, USA, 2Donghua University, Shanghai, China     P3012

Overcoming the Ill Effects of Aging Around the World

945. Influence of polyphosphodiesters having high mineral affinity on differentiation of bone cells, Yasuhiko Iwasaki1, Kenjiro Kiyono1, Shun Mabuchi1, Akihisa Otaka1,2, 1Kansai University, Osaka, Japan, 2National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan  P3113

946. Printing the Intervertebral Disc: A Hyaluronan-Collagen Bioink Analogue of the Nucleus Pulposus, Gregor Miklosic1,2, Stéphanie De Oliveira3, Sébastien Grastilleur4, Catherine Le Visage4, Christophe Hélary3, Stephen Ferguson2, Matteo D'Este1, 1AO Research Institute Davos, Davos, Switzerland, 2ETH Zürich, Zürich, Switzerland, 3Sorbonne Université, Paris, France, 4Université de Nantes, Nantes, France   P3114

Peptides as Therapeutics and Biomaterials

948. Multi-component symmetric self-assemblies of a collagen-mimetic peptide yield hydrogels that support cell growth, Jinyi Yang1, Andrew Khalil2, I. Caglar Tanrikulu1, Rudolf Jaenisch1,2, Ronald Raines1, 1Massachusetts Institute of Technology, Cambridge, MA, USA, 2Whitehead Institute, Cambridge, MA, USA   P3116

949. Delivery of Bioactive siRNA via LHRH-Targeting Fusogenic Peptide for the Treatment of Ovarian Cancer, Carleigh Coffin, Timothy Samec, PhD, Kharimat Lora Alatise, Serena Gilmore, Anthony Hazelton, Angela Alexander-Bryant, PhD, Clemson University, Clemson, SC, USA  P3117

950. Development of a Multi-Functional Peptide for siRNA delivery for treatment of Glioblastoma Multiforme, Jessie Boulos, Jorrian Abadeer, Tyler Willis, Kay Russi, Angela Alexander-Bryant, Ph.D., Clemson University, Clemson, SC, USA   P3118

951. Novel In Vitro Models for Studying Damaged Extracellular Matrices with Collagen Hybridization Peptides, Mallory Longacre1, Diana Legarda, PhD2, Lucas Bennink, PhD1, Michael Kirkness, PhD1, Daniel Ammon, PhD2, 13Helix, Inc., Salt Lake City, UT, USA, 2Collagen Matrix, Inc., Oakland, NJ, USA  P3119

952. Characterizing Structural Properties of Self-Assembling Peptides for Glioblastoma Multiforme Drug Delivery, Megan Pitz, Angela Alexander-Bryant, Clemson University, Clemson, SC, USA  P3120

953. Mineral-Binding Peptide Reduces Effect of Ectopic Mineralization, Samantha McGoldrick, Haichun Pan, PhD, Yuji Mishina, PhD, David Kohn, PhD, University of Michigan, Ann Arbor, MI, USA  P3121

Sex, Ancestral and Geographical Determinants in Biomaterials Research

954. Evaluating Donor Cell Variability In Mineralized Collagen Scaffolds, Vasiliki Kolliopoulos, BS, Brendan Harley, PhD, Aleczandria Tiffany, PhD, University of Illinois at Urbana-Champaign, Urbana, IL, USA    P3122

955. Sex Differences in NF-κB-targeted Therapy for Chronic Inflammatory Diseases in Preclinical Model. Masakazu Toya, MD, PhD, Junichi Kushioka, MD, PhD, Huaishuang Shen, MD, Ning Zhang, PhD, Masanori Tsubosaka, MD, PhD, Qi Gao, PhD, Xueping Li, PhD, Simon Chow, PhD, Stuart Goodman, MD, PhD, Stanford University, School of Medicine, Palo Alto, CA, USA    P3123  

Smart Biomaterials

956. Enhanced Inactivation of Pseudo-particles Containing SARS-CoV-2 S Protein using Magnetic Nanoparticles and an Alternating Magnetic Field, Pranto Paul, Kearstin Edmonds, Kevin Baldridge, Dibakar Bhattacharyya, Thomas Dziubla, Rebecca Dutch, Zach Hilt, University of Kentucky, Lexington, KY, USA  P3124

957. Glucose-Responsive Biomaterials from Diboronate Motifs with Increased Glucose Specificity, Sijie Xian, MS, Yuanhui Xiang, PhD, Matthew Webber, PhD, University of Notre Dame, Notre Dame, IN, USA   P3125

958. Bioprinting Remotely-Controllable Ultrasound-Responsive Tissue Constructs for Cellular Manipulation, Mary Lowrey, Holly Day, Angels Vasquez, Anthony Tahayeri, Katherine Huynh, Luiz Bertassoni, D.D.S., PhD, Carolyn Schutt, PhD, Oregon Health and Science University, Portland, OR, USA   P3126

959. Identification of Membrane Specific Protease Substrate Peptides for Localized Degradation. Yingjie Wu, MS, Eugene Pashuck, PhD, Lehigh University, bethlehem, PA, USA    P3127  

Black and LatinX Voices in Biomaterials

960. Digital Model of an In Vitro DC Electrical Stimulation Cell System, Jordan Gamble, Elizabeth Friis, PhDUniversity of Kansas, Lawrence, KS, USA   P3128

RAPID FIRES: Poster Session III - Friday, April 21st, 3:30 PM - 5:00 PM

RAPID FIRE - 3D and NANO BIOMATERIALS

961. Bone-targeted Nanoparticles Modulate Macrophage-mediated Fracture Healing, Baixue (Dorothy) Xiao1, Danielle Benoit1,2, Marian Ackun-Farmmer1, Yuchen Wang1, 1University of Rochester, Rochester, NY, USA, 2University of Oregon, Eugene, OR, USA    P3129

962. Effect of Lipid Saturation and Cholesterol Concentration on Liposome Interaction with Fungal and Mammalian Cells, Veronica LaMastro, Kayla Campbell, PhD, Peter Gonzalez, Tobias Meng-Saccoccio, Anita Shukla, PhD, Brown University, Providence, RI, USA    P3130

963. 3D Printed Gelatin Methacrylate Models for Normal and Glaucomatous Trabecular Meshwork Studies, Bikram Adhikari1, Mina Pantcheva, MD2, Melissa Krebs, PhD1, 1Colorado School of Mines, Golden, CO, USA, 2University of Colorado School of Medicine, Aurora, CO, USA   P3131

964. A 3D Platform to Study Monocyte Activation in Systemic Lupus Erythematosus, Holly Ryan, Mark Segal, MD, PhD, Erika Moore, University of Florida, Gainesville, FL, USA    P3132

965. Modeling Age in Macrophage-Endothelial Interactions and Therapeutic Interventions in a 3D PEG Hydrogel, Justin Silberman, Erika Moore, PhD, University of Florida, Gainesville, FL, USA    P3133

966. Desmoplastic Pancreatic Adenocarcinoma Mimicking Hydrogels for Modelling 3D Cancer Spheroids, Menekse Ermis, MD, PhD1, Natashya Falcone, PhD1, Natan Barros, PhD1, Marvin Mecwan, PhD1, Reihaneh Haghniaz, PhD1, Auveen Choroomi1, Mahsa Monirizad1, Yangzhi Zhu, PhD1, Ali Khademhosseini, PhD1, Junmin Lee, PhD2, Han-Jun Kim1, 1Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA, 2Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, Republic of Korea     P3134

967. Lipid-polymer hybrid “Particle-in-Particle” nanostructure gene delivery platform explored for lyophilizable DNA and mRNA COVID-19 vaccines, Zhongyu Li, Xiaoyang Xu, New Jersery Institute of Technology, Newark, NJ, USA    P3135

968. Development of an Injectable Upconversion Nanoparticle conjugated Doxorubicin Theranostics Electrospun Nanostructure for Breast Cancer, Amreen Khan, Mayuri Gandhi, Jayesh Bellare, Professor, Rohit Srivastava, Professor, Indian Institute of Technology Bombay India, Mumbai, India   P3136

970. Investigation of the Protein Corona’s Impact on Nanoliposome Drug Delivery Systems in Cancer Cells Using QCM-D, Nicholas Van Der Sanden, Maryam Tabrizian, PhD, McGill University, Montreal, QC, Canada   P3138

RAPID FIRE - Biomaterials for Regenerative Engineering

971. Gaussian Curvature-Driven Direction of Cell Fate Towards Osteogenesis with Triply Periodic Minimal Surface Scaffolds, Xin Zhao, PhD, The Hong Kong Polytechnic University, ,Hong Kong, China    P3139

972. In vitro screening of engineered extracellular matrices as tissue engineered periosteum to promote allograft healing. Alyson March1, Yiming Li, PhD1, YoungJoo Lee1,2, Regine Choe, PhD1, Danielle Benoit, PhD1,3, 1University of Rochester, Rochester, NY, USA, 2Gwangju Institute of Science and Technology, Gwangju, Republic of Korea, 3University of Oregon, Eugene, OR, USA    P3140

973. 3D Printing with Photopolymerizable Polyester Resins for Resorbable Tissue Scaffold Applications, Mathew Stanford, M.S.1,2, Melinda Harman, Ph.D.2, Michael Vaughn, Ph.D.1,2, 1Poly-Med, Inc., Anderson, SC, USA, 2Clemson University, Clemson, SC, USA    P3141

974. Functionalization of 3D-Printed Scaffolds with 2D Heterostructures and Immuno-regulative Cytokines for Osteo-Immunomodulated Bone Repair, Xifeng Liu, PhD, Lichun Lu, PhD, Mayo Clinic, Rochester, MN, USA    P3142

975. Licensed hMSCs exhibit enhanced immunomodulatory capacity in a biomaterial mediated manner, Vasiliki Kolliopoulos, BS, Brendan Harley, PhD, University of Illinois at Urbana-Champaign, Urbana, IL, USA  

976. Elucidating Mechanism of Action of Injectable Extracellular Matrix Hydrogel in a Model of Tongue Fibrosis. Emma Zelus, BS, Marianna Alperin, MD, MS, Andrew Vahabzadeh-Hagh, MD, Karen Christman, PhD, UC San Diego, La Jolla, CA, USA  P3143

977. Investigating The Combinatory Effect of Raspberry Ketone and Simvastatin on In Vitro Osteodifferentiation for Application in Guided Bone Regeneration, Matthew Atwill1,2, Joel Bumgardner, PhD1,2, 1The University of Memphis, Memphis, TN, USA, 2The University of Tennessee Health Science Center, Memphis, TN, USA   P3144

978. Combinatorial Effects of Surface Modification of Poly (glycerol-dodecanedioate) on Chondrocyte Behavior, Yue Qin, PhD, Rhima Coleman, PhD, University of Michigan,, Ann Arbor, MI, USA      P3145

979. Anisotropy and Stiffness of Tunable Collagen Scaffolds Drive Endothelial Inflammatory Phenotype, Myogenesis and Osteogenesis, Yong How Tan, Krista Habing, Karina Nakayama, PhD,Oregon Health & Science University, Portland, OR, USA     P3146

980. Semi-synthetic Hyaluronic Acid Hydrogels Promote Muscle Regeneration by Inducing BAT Differentiation of FAPs, Morgan Pfaff1, Anouk Killaars, PhD1, Derek Ning1, Michael Davies, MD2, Anthony Nguyen2, Prashant Nuthalapati2, Mengyao Liu2, Xuhui Liu, PhD2, Brian Feeley, MD2, Kevin Healy, PhD1, 1University of California, Berkeley, Berkeley, CA, USA, 2University of California, San Francisco, San Francisco, CA, USA      P3147

RAPID FIRE - Cardiovascular Biomaterials (SIG)

981. Pro-healing Nanomatrix Coated Stent Analysis in an In Vitro Vascular Double-Layer System and in a Rabbit Mode, Ho-Wook Jun1,2, Xixi Zhang1, Jun Chen1, Brigitta Brott1,2, Peter Anderson1, Patrick Hwang2, Jennifer Sherwood2, Gillian Huskin1, Young-sup Yoon, Renu Virmani3  1University of Alabama at Birmingham, Birmingham, AL, USA, 2Endomimetics, LLC, Birmingham, AL, USA, 3CVPath Institute, Inc., Gaithersburg, MD, USA    P3148

982. Implantable Vascular Platform with Multi-Material Stent and Printed, Soft Sensors for Wireless Monitoring of Restenosis, Robert Herbert, Woon-Hong Yeo, Georgia Institute of Technology, Atlanta, GA, USA     P3148

983. Targeting Tissue-resident Macrophage Secreted MCP-1 for Attenuating Inflammation After Myocardial Infarction, Jiaxing Wen, Ya Guan, PhD, Hong Niu, PhD, Yu Dang, PhD, Jianjun Guan, PhD, Washington University in St. Louis, Saint Louis, MO, USA    P3150

985. 3D-Printed Low-Profile and Mechanically Competent Bioresorbable Vascular Scaffolds, Yonghui Ding, PhD, Cheng Sun, PhD, Guillermo Ameer, ScD, Northwestern University, Evanston, IL, USA  P3153

986. Decoy Exosomes Offer Protection Against Chemotherapy-Induced Cardiotoxicity, Zhenhua Li1, Maio Fan1, Ke Cheng2, 1Southern Medical University, Guangdong, China, 2NC State University, Raleigh, NC, USA   P3154

987. Metallic Bioresorbable Flow Diverters for the Treatment of Intracranial Aneurysms, Alexander Oliver, BS1,2, Cem Bilgin, MD2, Andrew Vercnocke, BS2, Kent Carlson, PhD2, Ramanathan Kadirvel, PhD2, Roger Guillory, II, PhD3, Adam Griebel, MS4, Jeremy Schaffer, PhD4, Dan Dragomir-Daescu, PhD1,2, David Kallmes, MD1,2, 1Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA, 2Mayo Clinic, Rochester, MN, USA, 3Michigan Technological University, Houghton, MI, USA, 4Fort Wayne Metals, Fort Wayne, IN, USA   P3155

988. Cell-Laden Bead Bath to Support Extrusion Bioprinting of Vascularized Constructs, Irene Zhang, Nicole Friend, Emily Margolis, Andrew Putnam, PhD, University of Michigan, Ann Arbor, MI, USA   P3156

989. Development and Testing of Combinatorial Biomaterials for Increased Biocompatibility, Christopher Siedlecki, PhD1, Yi Wu2, Keren Beita2, Chad Schmeidt, DVM2, Hitesh Handa, PhD2, Li-Chong Xu, PhD1, 1Penn State College of Medicine, Hershey, PA, USA, 2University of Georgia, Athens, GA, USA     P3157

990. Substrate Stiffness Modulates Endothelial Phenotypic Transition, Maedeh Zamani, PhD1, Yu-Hao Cheng, MD2, Patrick Cahan, PhD2, Ngan Huang, PhD1, 1Stanford University, Stanford, CA, USA, 2Johns Hopkins University, Baltimore, MD, USA    P3158

RAPID FIRE - Drug Delivery (SIG)

991. Engineering Siloxane-Derived Lipid Nanoparticles for Tissue-Specific mRNA Therapeutics Delivery, Lulu Xue, PhD1, Gan Zhao, PhD2, Ningqiang Gong, PhD1, Xuexiang Han1, Sarah Shepherd1, Claude Clarence Warzecha3, Rakan El-Mayta1, Mohamad-Gabriel Alameh4, Lili Wang3, Drew Weissman4, Andrew Vaughan2, James Wilson3, Michael Mitchell1, 1Department of Bioengineering, Philadelphia, PA, USA, 2School of Veterinary Medicine, Philaldelphia, PA, USA, 3Perelman School of Medicine, Philadelphia, PA, USA, 4Department of Medicine, Phialdelphia, PA, USA    P3159

992. Targeting the Protease-Activated Receptor-2 (PAR2) with Nanotherapeutics to Reduce Oral Cancer Pain, Divya Bhansali, MS1, Tu Nguyen, PhD2, Tianyu Li, PhD1, Kenji Inoue, PhD2, Chloe Peach, PhD2, Raquel Tonello, PhD2, Dane Jensen, PhD2, Nigel Bunnett, PhD2, Brian Schmidt, MD, DDS, PhD2, Kam Leong, PhD1, 1Columbia University, New York, NY, USA, 2New York University, New York, NY, USA   P3160

993. Engineering Ligand-Tethered Lipidoids for Targeted RNA Delivery to Treat Liver Fibrosis, Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret Billingsley, Sarah Shepherd, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA   P3161

994. Dual Responsive Nanoparticles for Precision Therapy of Rheumatoid Arthritis, Gizem Erensoy, PhD, Luca Menges, Tilia Selldén, Alexandra Stubelius, PhD, PharmD, Chalmers University of Technology, Gothenburg, Sweden     P3162

995. Host-Modified Hydrogels Enable Sustained Release Through Engineered Biomolecule Avidity, Arielle D'Elia, M.S., Christopher Rodell, PhD, Drexel University, Philadelphia, PA, USA      P3163

996. Self-Assembled Oligo-Urethane Nanoparticles for Intracellular Delivery of mRNA, Suja Shrestha1,2, Ryan Marks3,4, Sina Fatehi3,4, Allen Teng2,5, Meghan McFadden, PhD2,6, Ronald Cohn3,4, Evgueni Ivakine3,5, Anthony Gramolini2,5, Paul Santerre1,2,6, 1Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, 2Translational Biology and Engineering Program (TBEP) and Ted Rogers Centre for Heart Research, Toronto, ON, Canada, 3Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada, 4Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada, 5Department of Physiology, University of Toronto, Toronto, ON, Canada, 6Institute of Biomedical Engineering, Toronto, ON, Canada   P3164

997. A Local Release, Reloadable Antibiotic Delivery Device Manages Biofilm Hardware-Related Infection Better than Clinical Standards, Robert Falconer1, Walker Kay1, Connor Hunt1, Jacob Adams1, Alice Miller1, Korinna Hylen1, Tyler Smith1, Lisa Nehring1, Brooke Kawaguchi1, Richard Epperson1, Brian Barnum2, Nicholas Ashton, PhD1,2, Dustin Williams, PhD1,2, 1University of Utah, Salt Lake City, UT, USA, 2Purgo Scientific, Draper, UT, USA    P3165

998. Tissue-reactive Drugs Enable Materials-free Local Depots, Rukesh Chinthapatla, Sharda Pandit, Belen Neumann-Rivera, Sandeep Palvai, Nicholas Massaro, Joshua Pierce, Yevgeny Brudno, North Carolina State University, Raleigh, NC, USA     P3166

999. Uricase Functionalized Hydrogel for the Localized Treatment of Gout, Madeline Fuchs, Gregory Hudalla, PhD, Benjamin Keselowsky, University of Florida, Gainesville, FL, USA     P3167

1000. Zwitterionic Peptide Sequence Determines Anti-Fouling Behavior and Protein Adsorption Profile on Nanoparticle Surfaces, Clyde Overby, III, M.S.1,2, Danielle Benoit, Ph.D.1,2,3, 1University of Rochester, Rochester, NY, USA, 2University of Rochester Medical Center, Rochester, NY, USA, 3University of Oregon, Eugene, OR, USA     P3168

RAPID FIRE - Engineering Cells & Their Microenvironments (SIG)

1001. Compressive Mechanical Load Modulates the Secretome and Cytoskeleton of MSC Spheroids, Sabrina Mierswa, Victoria Thai, J. Kent Leach, PhD, University of California Davis, Davis, CA, USA     P3169

1003. Nanoparticle Interaction with Extracellular Matrix Stabilizes Cartilage Tissue Integrity. Ula von Mentzer, Gizem Erensoy, PhD, Stefanny de Fatima Guedes Cunha, Sara Yousefialdashi, Alexandra Stubelius, PhD, PharmD, Chalmers University of Technology, Gothenburg, Sweden     P3171

1004. Tunable Gelatin Methacrylate Polyethylene Glycol Hydrogels for Cell Mechanosensing Applications. Eya Ferchichi, Silviya Petrova Zustiak, PhD, Saint Louis University, Saint Louis, MO, USA     P3172

1005. Fibronectin’s EDA Region Mechanoregulates Matrix Microarchitecture During Wound Healing, Jennifer Patten, Michael Kegel, Fatima Ahmed, Patrick Halligan, Karin Wang, Temple University, Philadelphia, PA, USA    P3173

1006. Spatial confinement modulates macrophage response in microporous scaffolds, Alejandra Suarez-Arnedo, Yining Liu, Lindsay Riley, Eleanor Caston, Tasman Miley, Michelle Schneider, Tatiana Segura, Duke University, Durham, NC, USA    P3174

1007. The Influence of Hyaluronic Acid Properties on Natural Killer Cell Function in an Engineered Hydrogel System, Suzanne Lightsey, Madison Temples, Benjamin Kaufman, Tiffany Conklin, Blanka Sharma, University of Florida, Gaineville, FL, USA   P3175

1008. Atomic Vacancy Rich 2D Nanoparticles Drive Mitochondrial Biogenesis and Bioenergetics, Kanwar Abhay Singh1, John Soukar1, Mohammad Zulkifli1, Irtisha Singh1,2, Vishal Gohil1, Akhilesh Gaharwar1, 1Texas A&M University, College Station, TX, USA, 2Texas A&M Health Science Center, Bryan, TX, USA    P3176

1009. Co-assembled Peptide-Protein Granules for Cytosolic Protein Delivery, Stephanie Herrera, Renjie Liu, PhD, Jennifer Simonovich, Gregory Hudalla, PhD, Benjamin Keselowsky, PhD, University of Florida, Gainesville, FL, USA   P3177

1010. Optogenetically-Controlled Bacterial Persistence, Yousr Dhaouadi, BS Chemical Engineering, Dacheng Ren, Syracuse University, Syracuse, NY, USA    P3178

RAPID FIRE - Immune Engineering (SIG)

1011. Development of Intranasal Vaccine System Using Hyaluronic Acid-Coated Polymeric Micelles, Yuichi Ohya, PhD1, Kengo Suzuki1, Yuta Yoshizaki, PhD2, Nobuo Murase, PhD1, Kenta Horii1, Takuma Kato1, Akinori Kuzuya, PhD1, 1Kansai University, Suita, Japan, 2Tohoku University, Sendai, Japan    P3179

1012. Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering, Alex Hamilton, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA    P3180

1013. Cytokine-Loaded Nano-in-Cryogel Biomaterials for Repolarization of Tumor Associated Macrophages, Sydney Henriques1, Ori Chalom1, Evan Glass, PhD1, Sohini Roy, PhD2, Abigail Manning1, Benjamin Hacker1, Marjan Rafat, PhD1, Laura Kennedy, MD2, Fiona Yull, PhD1, Young Kim, MD, PhD2, Todd Giorgio, PhD1, 1Vanderbilt University, Nashville, TN, USA, 2Vanderbilt University Medical Center, Nashville, TN, USA   P3181

1014. mRNA Lipid Nanoparticles for ex vivo Engineering of Primary Human T Cells for Autoimmunity Therapies, Ajay Thatte, Alex Hamilton, Margaret Billingsley, Alvin Mukalel, Michael Mitchell, PhD, University of Pennsylvania, Philadelphia, PA, USA    P3188

1015. Antigen-Decorated Liposomal Hydrogels for Robust and Durable Protection against SARS-CoV-2 Infections, Julie Baillet1,2, John Klich1, Ben Ou1, Sebastien Lecommandoux2, Eric Appel1, 1Stanford University, Stanford, CA, USA, 2University of Bordeaux, Talence, France    P3182

1016. Cationic Exosomes Anchored with Receptor Antagonist of IL-1 for Cartilage Targeting and Repair, Tanvi Vinod Pathrikar, Chenzhen Zhang, Helna Baby, Ambika Bajpayee, Northeastern University, Boston, MA, USA  P3183

1017. Augmented anticancer efficacy of natural killer cells via surface functionalized quantum dots using PD-1 binding peptides, Sehwan Jeong, Kyobum Kim, Min-Jae Choi, Woo-Jin Jeong, Dongguk University, Inha University   P3184

1018. In situ engineering of an immunologically active tumor microenvironment with cold-responsive nanoparticles for cryoimmunotherapy of breast cancer, Wenquan Ou, PhD, Samantha Stewart, BS, Alisa White, MS, James Shamul, MS, Xiaoming He, PhD, University of Maryland, College Park, MD, USA   P3185

1019. IL-12-Based Cytokine Factories Modulate Tumor Microenvironment to Eradicate Pancreatic Tumors in Mice and are Well Tolerated in Non-human Primates, Samira Aghlara-Fotovat1, Bertha Castillo1, Peter Rios2, Sofia Ghani2, Ira Joshi2, Douglas Isa2, Jose Oberholzer2, Omid Veiseh1, Amanda Nash, 1Rice University, Houston, TX, USA, 2CellTrans Inc, Chicago, IL, USA     P3186

1020. Monitoring melanoma responses to STING agonism and focused ultrasound thermal ablation using microneedles and ultra-sensitive single molecule arrays, Daniel Dahis, PhD Student1,2,3, Michele Dion, PhD Student2,3,4, Alexander Cryer, PhD2,3,4, Tal Gilboa, PhD2,3, Mariana Alonso2, Michael Lewandosky, PhD2,3, Nuria Puigmal2,3,4, Haim Azhari, PhD1, Rushdy Ahmed, PhD2,3, David Walt, PhD2,3, Natalie Artzi, PhD2,3,4, 1Technion Institute of Technology, Haifa, Israel, 2Brigham and Women's Hospital, Boston, MA, USA, 3Wyss Institute, Boston, MA, USA, 4MIT, Cambridge, MA, USA    P3187

RAPID FIRE - Tissue Engineering (SIG)

1012. Vascularizing 3D Printed GelMA Hydrogel for Pancreatic Islet Transplantation, Martha Fowler, M.S., Boram Kim, Cody Fell, Michael Doerfert, M.S., Shalini Pandey, PhD, Joe Swain, Chris Wright, Jeffrey Hartgerink, PhD, Omid Veiseh, PhD, Rice University, Houston, TX, USA    P3189

1022. A nanofiber-hydrogel scaffold embedded with adipose-derived stem cells for treatment of Crohn’s perianal fistulas, Zhicheng Yao1,2,3,4, Ling Li1,5, Susan Gearhart1,6, Florin Selaru1,5, Hai-Quan Mao1,2,3,4,7, Alyssa Parian1,5, 1Johns Hopkins University, Baltimore, MD, USA, 2The Johns Hopkins University School of Medicine, Translational Tissue Engineering Center, Baltimore, MD, USA, 3The Johns Hopkins University, Institute for NanoBioTechnology, Baltimore, MD, USA, 4The Johns Hopkins University, Whiting School of Engineering, Department of Materials Science and Engineering, Baltimore, MD, USA, 5The Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, USA, 6The Johns Hopkins University School of Medicine, Department of Surgery, Baltimore, MD, USA, 7The Johns Hopkins University, Whiting School of Engineering, Department of Biomedical Engineering, Baltimore, MD, USA      P3190

1023. Development of Shrink Wrapped Endothelial Tubule Segments for Tissue Vascularization, Shubhangi Sathyakumar, Rachelle Palchesko, Ph.D., Jacqueline Bliley, Ph.D., Adam Feinberg, Ph.D., Carnegie Mellon University, Pittsburgh, PA, USA    P3191

1024. Conductive Electrospun Polymer Platforms Improve Stem Cell-Derived Cardiomyocyte Function and Maturation, Gisselle Gonzalez, Aileena Nelson, Erin LaMontagne, Alexander Whitehead, PhD, Ritwik Vatsyayan, Shadi Dayeh, PhD, Adam Engler, PhD, University of California, San Diego, La Jolla, CA, USA    P3192

1025. Light-Pipe FRESH 3D Bioprinting for Engineering Spatial Heterogeneity of Tissue Scaffolds. Caner Dikyol, Adam Feinberg, PhD, Carnegie Mellon University, Pittsburgh, PA, USA    P3193

1026. Preliminary analysis of the effect of dissolution products of SCPC resorbable bioactive ceramic on nerve cells, Arjun Tiwari, Ph.D, In Hong Yang, Ahmed El-Ghannam, University of North Carolina at Charlotte, Charlotte, NC, USA     P3194

1027. Engineering adipose tissue using edible scaffolds with tunable stiffness for cultured meat, Kathleen Chen, Sam Norris, Amy Rowat, Associate Professor, Nora Kawecki, University of California, Los Angeles, Los Angeles, CA, USA   P3195

1028. Two-dimensional Nanosilicates Stimulate Angiogenesis in Endothelial Cells, Giriraj Lokhande1, Kanwar Abhay Singh1, Anna Kersey1, Irtisha Singh, Ph.D1,2, Akhilesh Gaharwar1, 1Texas A&M University, College Station, TX, USA, 2Texas A&M Health Science Center, Bryan, TX, USA   P3196

1029. Incorporating elastomeric particles into bioinks to enhance 3D-printed tissues stability. Shira Landau, PhD, Jennifer Kieda, Sargol Okhovatian1, Kaitlyn Ramsay, PhD, Chuan Liu, Milica Radisic, PhD, University of Toronto, Toronto, ON, Canada   P3197

1030. Fibrous Topographical Cues Govern Tenogenic vs. Chondrogenic Fate Switch. Robert Kent, III, MS, Maggie Jewett, BS, Daniel Matera, PhD, Ariella Shikanov, PhD, Brendon Baker, PhD, University of Michigan, Ann Arbor, MI, USA   P3198