1D: Peptides as Therapeutics and Biomaterials

Timeslot: Wednesday, April 19, 2023 - 1:00pm to 2:30pm
Room: Coral 1-2

About

Peptides are chemically defined and possess a wide range of biofunctions including ligand binding, proteolytic susceptibility, and self-assembly. Owing to these features, peptide-based biomaterials show wide range of capacities to encapsulate payload, to engage cellular receptors, respond to stimuli and surrounding environments, and modulate cell functions as drug or immune antigens. These unique advantages, along with an outstanding safety profile, make peptide-based biomaterials very attractive in a variety of biomedical applications including stimuli-responsive biomaterials, drug delivery, tissue regeneration, and immune modulation. This session will cover all aspects of peptide-based therapeutics and biomaterials ranging from fundamental concepts of self-assembly to therapeutic applications. We will feature recent advances in the development of biomaterials including, but not limited to, peptides acting as bioactive components, peptides functioning as targeting ligands, and peptides serving as scaffold building blocks. We will highlight applications including biomedical imaging, disease diagnosis and treatment, tissue regenerations, and immune modulations.

  • 1:00 PM 17. Targeted Delivery of Peptide-Functionalized Nanoparticles to Improve Tendon Healing. Emmanuella Adjei-Sowah, Alayna Loiselle, PhD, Danielle Benoit, PhD, University of Rochester, University of Oregon.

  • 1:15 PM 18. Spatial Configuration of Charge Modulates Transport of Cationic Carriers in Cartilage Matrix. Bill Hakim, Timothy Boyer, Dr. Ambika Bajpayee. Northeastern University.

  • 1:30 PM 19. A Targeted Fusogenic Peptide Alters siRNA Delivery in Ovarian Cancer. Kharimat Lora Alatise, Angela Alexander-Bryant, PhD. Clemson University.

  • 1:45 PM 20. Temperature Modulates the Assembled Structure of Co-Assembling Synthetic Peptides. Ryan Clark, Benjamin Keselowsky, PhD, Gregory Hudalla, PhD, University of Florida.

  • 2:00 PM 21. Post-translational glycosylation of polypeptide tags for modification of protein assembly and receptor targeting. Eric Hill,MS; Alexander Kwiatkowski, PhD, Gregory Hudalla, PhD, Benjamin Keselowsky, PhD. University of Florida.

  • 2:15 PM 22. Epsin mimetic UPI peptide delivery strategies to improve endothelization of vascular grafts. Dr. Chris Bashur, Shirin Changizi, Dr. Mayyar Sameti, Dr. Hong Chen, Florida institute of Technology, Boston Children’s Hospital - Harvard University.