3B: Granular Hydrogel Scaffolds
Timeslot: Thursday, April 20, 2023 - 10:30am to 12:00pm
Room: Silver Pearl 2
About
Granular hydrogel materials emerged as a class of biomaterial that provide for well-defined in vitro and in vivo systems with plug-and-play components and tissue-mimicking 3D environments. Granular hydrogels are composed of a slurry of microgel particles that are assembled to form a larger porous structure. Microporous annealed particle scaffolds (MAPS) are a subclass of granular hydrogel material with a void space network stabilized by inter-particle chemical bonds. The modular nature of granular hydrogels offers enormous tunability in not only the individual microgel design but also the homogenous or heterogenous microgel assembly into the bulk scaffold. This session will explore current advances in granular hydrogel technology, including MAPS, for both immune modulation, tissue repair, organ-on-a-chip, and 3D-printing applications.
10:30 AM. 98. Conjugation of IL-33 to Microporous Annealed Particle Scaffolds Initiates Type 2 Immune Response in Vitro and in Vivo. Colleen Roosa, Samantha Lempke, Riley Hannan, PhD, Jeffrey Sturek, PhD, MD, Sarah Ewald, PhD, Donald Griffin, PhD, University of Virginia.
10:45 AM. 99. Injectable Cellular Spheroid and Microgel Granular Composites for Cartilage Repair. Nikolas Di Caprio, Matthew D. Davidson, PhD, Jason A. Burdick, PhD, University of Pennsylvania, Biofrontiers Institute.
11:00 AM. 100. Biomaterial Microstructure and Spatial Bioactivity in Microporous Annealed Particle (MAP) Scaffolds Guides Endothelial Cell Patterning and Lumen Formation. Alexa Anderson, Dimitris Ntekoumes, Sharon Gerecht, PhD, Tatiana Segura, PhD, Duke University, Johns Hopkins University.
11:15 AM 101. Impact of Thiol-Ene and Tetrazine Click Annealing Chemistry on Osteogenic Outcomes in a Calvarial Defect Model. Sarea Recalde Phillips, Elizabeth Ruben, Talia Baig, Carl Gregory, PhD, Daniel L. Alge, PhD, Texas A&M University.
11:30 AM 102. Influence of Microgel and Interstitial Matrix Compositions on Granular Hydrogel Composite Properties. Dr. Victoria Muir, Jason A. Burdick, University of Pennsylvania, University of Colorado.
11:45 AM 103. Single Microgel Species for Forming Guest-Host Microporous Annealed Particle PEG-MAL Hydrogels. Adrienne Widener, Abilene Roberts, Jorge Santini-Gonzalez, Edward A. Phelps, PhD, University of Florida.