4B: Drug Delivery (SIG)
Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Silver Pearl 2
About
The Drug Delivery Special Interest Group will deal with the science and technology of controlled release of active agents from delivery systems. Controlled drug release is achieved by the use of diffusion, chemical reactions, dissolutions or osmosis, used either singly or in combination. While the vast majority of such delivery devices are based on polymers, controlled release can also be achieved by the use of mechanical pumps. In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems. Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included.
1:30 PM. 142. INVITED SPEAKER
2:00 PM 143. Controlled Release of Bioactive Antibodies from a Modular Pulsatile Release Platform. Kevin McHugh, PhD, Tyler P. Graf, Erin M. Euliano, Mei-Li Laracuente, Rice University, Baylor College of Medicine.
2:15 PM 144. Direct Delivery of Plasmin using Clot-anchoring Thrombin-Responsive Nanoparticles for Targeted Fibrinolytic Therapy. Anirban Sen Gupta, PhD, Michael Sun, PhD, Maxine Hao Hao Pontius, Stephanie Yang, Shruti Raghunathan, Jordan A. Shavit, MD, PhD, Case Western Reserve University, University of Michigan.
2:30 PM 145. Evaluation of Clot-Targeted Nanogels for Anticoagulant and Fibrinolytic Dual-Delivery in a Rat Model of Disseminated Intravascular Coagulation. Ana Sheridan, Kimberly Nellenbach, PhD, Ashley C. Brown, PhD, Emily Mihalko, PhD, Nina Moiseiwitsch, Grant Scull, Elizabeth Byrnes, Sanika Pandit, North Carolina State University and University of North Carolina at Chapel Hill.
2:45 PM 146. A Conformable Compartmentalized MicroMESH for the Combinatorial Treatment of Glioblastoma. Paolo Decuzzi, PhD, Irene Guerriero, MSc, Cristiano Pesce, MSc, Daniele Dimascolo, PhD, Anna Lisa Palange, PhD, Italian Institute of Technology.
3:00 PM 147. Biodegradable Dendrimers for mRNA Therapeutics Delivery into the Ischemic Brain. Ana Paula Pego, PhD, Marília Torrado, Ana P. Spencer, Victoria Leiro, PhD, Sofia D. Santos, PhD, i3S - Instituto de Investigação e Inovação em Saúde / INEB - Instituto de Engenharia Biomédica, ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Faculdade de Engenharia da Universidade do Porto.
3:15 PM 148. Throughput-Scalable Silicon and Glass Microfluidic Platform for Manufacturing of SARS-CoV-2 mRNA Lipid Nanoparticles Vaccines. Sarah Shepherd, Dr. David Issadore, Dr. Michael Mitchell, University of Pennsylvania.