4F: Engineering Complex Tissues

Timeslot: Thursday, April 20, 2023 - 1:30pm to 3:30pm
Room: Coral 5

About

Native tissues are hierarchically organized and composed of multiple cell types and extracellular matrix molecules that are critical for normal tissue function and dysregulated in disease states. This session will focus on novel methodologies to engineer complex tissues and systems for applications in tissue regeneration, disease modeling, drug screening, developmental biology, etc. Abstracts describing approaches to generate multicomponent systems with multiple cell types and biochemical and physical cues are of particular interest.

  • 1:30 PM 173. Mechanically-Mediated Biochemical Signaling Guides Assembly and Maturation of Engineered Multicellular Tissues. Ritu Ramen, Naomi Lynch, Angel Bu, Massachusetts Institute of Technology.

  • 1:45 PM 174. 3D Bioprinting of Dense Cellular Structures within Functional Hydrogels. Murat Guvendiren, PhD, Alperen Abaci, New Jersey Institute of Technology.

  • 2:00 PM 175. A Modular Microreactor for the Preparation, Maintenance and Conditioning of Multilayer Tissues or Multi-Tissue Structures. Luca Gasperini, Ana I. Soares, Zahara Eltayari, Rui L. Reis, Alexandra P. Marques, 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, ICVS/3B’s – PT Government Associate Laboratory.

  • 2:15 PM 176. Investigating Paracrine Signaling in a Triphasic Biomaterial for Rotator Cuff Repair. Kyle B. Timmer, Megan Killian, PhD, Brendan A. Harley, Sc.D., University of Illinois Urbana-Champaign, University of Michigan.

  • 2:30 PM 177. Cytokine and T cell Stimulus Differentially Regulates Aged B cell Activation and ECM Remodeling. Secil Demir, PhD, Zhe Zhong, Sona Desai, Dr. Ankur Singh, Georgia Institute of Technology.

  • 2:45 PM 178. Engineering Microscale Co-cultures of iPSC-derived Cardiomyocytes and Fibroblasts via Photopatterned Alginate. Derrick Wells, MS, Yong Duk Han, PhD, Eben Alsberg, PhD, Salman R. Khetani, PhD, University of Illinois at Chicago.

  • 3:00 PM 179. Heart-On-A-Chip with Vascular Plexus for Drug Testing. Yimu Zhao, PhD, Gordana Vunjak-Novakovic, PhD, Milica Radisic, PhD, University of Toronto, Columbia University.

  • 3:15 PM 180. Cell Assembled 3D Tumor Stroma In-A-Dish Using Decellularized Extracellular Matrix Scaffolds. Matthew Wolf, PhD, Michael Buckenmeyer, PhD, Elizabeth Brooks, PhD, Madison Taylor, National Cancer Institute.