6C: Drug Delivery (SIG) RAPID FIRE
Timeslot: Friday, April 21, 2023 - 11:30am to 12:30pm
Room: Silver Pearl 3
About
The Drug Delivery Special Interest Group will deal with the science and technology of controlled release of active agents from delivery systems. Controlled drug release is achieved by the use of diffusion, chemical reactions, dissolutions or osmosis, used either singly or in combination. While the vast majority of such delivery devices are based on polymers, controlled release can also be achieved by the use of mechanical pumps. In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems. Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included.
11:30 AM. 281. Host-Modified Hydrogels Enable Sustained Release Through Engineered Biomolecule Avidity. Arielle D'Elia, M.S., Christopher Rodell, PhD, Drexel University, Philadelphia, PA, USA.
11:35 AM 282. Engineering Siloxane-Derived Lipid Nanoparticles for Tissue-Specific mRNA Therapeutics Delivery. Lulu Xue, PhD, Gan Zhao, PhD, Ningqiang Gong, PhD, Xuexiang Han, Sarah Shepherd, Claude Clarence Warzecha, Rakan El-Mayta, Mohamad-Gabriel Alameh, Lili Wang, Drew Weissman, Andrew Vaughan, James Wilson, Michael Mitchell, Department of Bioengineering, Philadelphia, PA, USA, School of Veterinary Medicine, Philaldelphia, PA, USA, Perelman School of Medicine, Philadelphia, PA, USA, Department of Medicine, Phialdelphia, PA, USA.
11:40 AM 283. Tissue-reactive Drugs Enable Materials-free Local Depots. Rukesh Chinthapatla, Sharda Pandit, Belen Neumann-Rivera, Sandeep Palvai, Nicholas Massaro, Joshua Pierce, Yevgeny Brudno, North Carolina State University, Raleigh, NC, USA.
11:45 AM 284. Targeting the Protease-Activated Receptor-2 (PAR2) with Nanotherapeutics to Reduce Oral Cancer Pain. Divya Bhansali, MS, Tu Nguyen, PhD, Tianyu Li, PhD, Kenji Inoue, PhD, Chloe Peach, PhD, Raquel Tonello, PhD, Dane Jensen, PhD, Nigel Bunnett, PhD, Brian Schmidt, MD, DDS, PhD, Kam Leong, PhD, Columbia University, New York, NY, USA, New York University, New York, NY, USA.
11:50 AM 285. Engineering Ligand-Tethered Lipidoids for Targeted RNA Delivery to Treat Liver Fibrosis. Xuexiang Han, Ningqiang Gong, Lulu Xue, Margaret Billingsley, Sarah Shepherd, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA.
12:00 PM 286. Zwitterionic Peptide Sequence Determines Anti-Fouling Behavior and Protein Adsorption Profile on Nanoparticle Surfaces. Clyde Overby, III, M.S., Danielle Benoit, Ph.D,University of Rochester, Rochester, NY, USA, University of Rochester Medical Center, Rochester, NY, USA, University of Oregon, Eugene, OR, USA.
12:05 PM 287. Uricase Functionalized Hydrogel for the Localized Treatment of Gout. Madeline Fuchs, Gregory Hudalla, PhD, Benjamin Keselowsky, University of Florida, Gainesville, FL, USA.
12:10 PM. 288. A Local Release, Reloadable Antibiotic Delivery Device Manages Biofilm Hardware-Related Infection Better than Clinical Standards. Robert Falconer, Walker Kay, Connor Hunt, Jacob Adams, Alice Miller, Korinna Hylen, Tyler Smith, Lisa Nehring, Brooke Kawaguchi, Richard Epperson, Brian Barnum, Nicholas Ashton, PhD, Dustin Williams, PhD, University of Utah, Salt Lake City, UT, USA, Purgo Scientific, Draper, UT, USA.
12:15 PM 289. Dual Responsive Nanoparticles for Precision Therapy of Rheumatoid Arthritis. Gizem Erensoy, PhD, Luca Menges, Tilia Selldén, Alexandra Stubelius, PhD, PharmD, Chalmers University of Technology, Gothenburg, Sweden.
12:20 PM 290. Self-Assembled Oligo-Urethane Nanoparticles for Intracellular Delivery of mRNA. Suja Shrestha, Ryan Marks, Sina Fatehi, Allen Teng, Meghan McFadden, PhD, Ronald Cohn, Evgueni Ivakine, Anthony Gramolini, Paul Santerre, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, Translational Biology and Engineering Program (TBEP) and Ted Rogers Centre for Heart Research, Toronto, ON, Canada, Genetics & Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada, Department of Physiology, University of Toronto, Toronto, ON, Canada, Institute of Biomedical Engineering, Toronto, ON, Canada.