6D: Immune Engineering (SIG) RAPID FIRE
Timeslot: Friday, April 21, 2023 - 11:30am to 12:30pm
Room: Coral 1-2
About
Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy (immune-modulation), cell and gene therapy, immune microenvironment engineering, and systems immunology. These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas.
11:30 AM 291. Monitoring Melanoma Responses to STING Agonism and Focused Ultrasound Thermal Ablation Using Microneedles and Ultra-Sensitive Single Molecule Arrays. Daniel Dahis, PhD Student, Michele Dion, PhD Student, Alexander Cryer, PhD, Tal Gilboa, PhD, Mariana Alonso, Michael Lewandosky, PhD, Nuria Puigmal, Haim Azhari, PhD, Rushdy Ahmed, PhD, David Walt, PhD, Natalie Artzi, PhD, Technion Institute of Technology, Haifa, Israel, Brigham and Women's Hospital, Boston, MA, USA, Wyss Institute, Boston, MA, USA, MIT, Cambridge, MA, USA.
11:35 AM 292. Cytokine-Loaded Nano-in-Cryogel Biomaterials for Repolarization of Tumor Associated Macrophages. Sydney Henriques, Ori Chalom, Evan Glass, PhD, Sohini Roy, PhD, Abigail Manning, Benjamin Hacker, Marjan Rafat, PhD, Laura Kennedy, MD, Fiona Yull, PhD, Young Kim, MD, PhD, Todd Giorgio, PhD, Vanderbilt University, Nashville, TN, USA, Vanderbilt University Medical Center, Nashville, TN, USA.
11:40 AM 293. Augmented Anticancer Efficacy of Natural Killer Cells via Surface Functionalized Quantum Dots Using PD-1 Binding Peptides. Sehwan Jeong, Kyobum Kim, Min-Jae Choi, Woo-jin Jeong, Dongguk University, Seoul, Republic of Korea, Inha University, Incheon, Republic of Korea.
11:45 AM 294. Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Alex Hamilton, Michael Mitchell,University of Pennsylvania, Philadelphia, PA, USA.
11:50 AM 295. Antigen-Decorated Liposomal Hydrogels for Robust and Durable Protection against SARS-CoV-2 Infections. Julie Baillet, John Klich, Ben Ou, Sebastien Lecommandoux, Eric Appel, Stanford University, Stanford, CA, USA, University of Bordeaux, Talence, France.
12:00 PM 296. Cationic Exosomes Anchored with Receptor Antagonist of IL-1 for Cartilage Targeting and Repair. Tanvi Vinod Pathrikar, Chenzhen Zhang, Helna Baby, Ambika Bajpayee, Northeastern University, Boston, MA, USA.
12:05 PM 297. In Situ Engineering of an Immunologically Active Tumor Microenvironment with Cold-Responsive Nanoparticles for Cryoimmunotherapy of Breast Cancer. Wenquan Ou, PhD, Samantha Stewart, BS, Alisa White, MS, James Shamul, MS, Xiaoming He, PhD, University of Maryland, College Park, MD, USA.
12:10 PM 298. mRNA Lipid Nanoparticles for ex vivo Engineering of Primary Human T Cells for Autoimmunity Therapies. Ajay Thatte, Alex Hamilton, Margaret Billingsley, Alvin Mukalel, Michael Mitchell, PhD, University of Pennsylvania, Philadelphia, PA, USA.
12:15 PM 299. Development of Intranasal Vaccine System Using Hyaluronic Acid-Coated Polymeric Micelles. Yuichi Ohya, PhD, Kengo Suzuki, Yuta Yoshizaki, PhD, Nobuo Murase, PhD, Kenta Horii, Takuma Kato, Akinori Kuzuya, PhD, Kansai University, Suita, Japan, Tohoku University, Sendai, Japan.
12:20 PM 300. IL-12-Based Cytokine Factories Modulate Tumor Microenvironment to Eradicate Pancreatic Tumors in Mice and are Well Tolerated in Non-human Primates. Samira Aghlara-Fotovat, Bertha Castillo, Peter Rios, Sofia Ghani, Ira Joshi, Douglas Isa, Jose Oberholzer, Omid Veiseh, Amanda Nash, Rice University, Houston, TX, USA, CellTrans Inc, Chicago, IL, USA.