7E: Musculoskeletal Regeneration
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Coral 3-4
About
Advances in tissue engineering and regenerative therapies have led to the development of innovative materials and approaches for the functional regeneration of musculoskeletal tissues, including muscles, bones, cartilage, tendons, and neural tissues. However, given the intricate nature of the musculoskeletal system and its interconnection with other bodily systems, there is a crucial need for continued progress in translational therapies that integrates engineering, medicine, immunology, developmental biology, stem cell research, and bioinformatics. The focus of this session is on the latest breakthroughs in the development of functional biomaterials, preclinical models, and engineered strategies for repairing and regenerating musculoskeletal tissues affected by disease, trauma, and aging.
2:00 PM 366. Engineered Skeletal Muscle in Space as a Novel Model Sarcopenia. Mahdis Shayan, PhD, Bugra Ayan, PhD, Soochi Kim, PhD, Thomas Rando, MD, PhD, Ngan Huang, PhD, Stanford University, Stanford, CA, USA.
2:15 PM 367. The Anti-SASP Ruxolitinib Modulates Aged Macrophage Phenotype Transitions and Promotes Aged Bone Healing. Yamin Liu, PhD, Kara Spiller, PhD, Liisa Kuhn, PhD, University of Connecticut Health Center, Farmington, CT, USA, Drexel University, Philadelphia, PA, USA.
2:30 PM 368. Sliding Hydrogels Attenuate the Inflammatory Phenotype of Osteoarthritic Chondrocytes via Mechanotransduction. Manish Ayushman, Xinming Tong, Pranay Agarwal, Nidhi Bhutani, Fan Yang, Stanford University, Stanford, CA, USA.
2:45 PM 369. Aspirin Synergizes with Optimized Calcium Phosphate Particles to Enhance Macroporous Scaffold-Mediated Bone Regeneration in Vivo. Ni Su, PhD, Cassandra Villicana, Fan Yang, Professor, Stanford University, Palo Alto, CA, USA.
3:00 PM 370. Biomimetic Proteoglycans Molecularly Engineer and Mechanically Modulate Human Osteoarthritic Cartilage. Elizabeth Kahle, Colette Trouillot, Paul DeSantis, Anish Aitha, Lin Han, Michele Marcolongo, Drexel University, Philadelphia, PA, USA, Villanova University, Villanova, PA, USA.
3:15 PM 371. Nanofibrillar Engineered Muscle Therapy Enhances Muscle and Bone Functional Healing in Composite Lower Extremity Trauma. Karina Nakayama, PhD, Cynthia Alcazar, Krista Habing, Zachary Working, MD, Nick Willett, PhD, Anthony Tahayeri, Luiz Bertassoni, DDS, PhD, Oregon Health & Science University, Portland, OR, USA, University of Oregon, Eugene, OR, USA.