7G: Biophysical Strategies for Regulation of Cellular Microenvironments
Timeslot: Friday, April 21, 2023 - 2:00pm to 3:30pm
Room: Seaglass
About
Biophysical factors directed by biomaterials are known to play important roles in regulating cellular behavior by influencing gene and protein expression, protein localization, and cell signaling activity. This session focuses on biomaterial-based strategies for regulating biophysical factors in engineered cellular microenvironments. Topics include but are not limited to novel uses of biomaterials for regulation of nano- and micro-topographical and ligand patterning cues, normal and shear stress environments, thermosensitive properties, and physical parameters of fiber networks for regulating cellular phenotype. This includes studies incorporating novel strategies for control of biophysical parameters in biomaterial design for engineering of physiological models as well as fundamental studies of the mechanisms by which cells utilize biophysical cues from the biomaterials in their microenvironment to elicit specific biological outcomes. The studies presented in this session will contribute to the design of next-generation biomaterials capable of precisely and predictably directing cellular behaviors.
2:00 PM 378. Multisized Photoannealable Microgels Regulate Cell Aggregation and Macrophage Phenotype through Microporous Void Space. Jeremy Lowen, Gabriella Bond, Katherine Griffin, Nathan Shimamoto, Victoria Thai, Jonathan Leach, University of California Davis, Davis, CA, USA.
2:15 PM 379. Regulating Biophysical Cues in Engineered Extracellular Matrices with Peptoids. Adrianne Rosales, Logan Morton, David Castilla-Casadiego, The University of Texas at Austin, Austin, TX, USA.
2:30 PM 380. Alginate Microfibers as Anisotropic Porogens to Enhance Vasculogenic Assembly in Dense Fibrin Hydrogels. Firaol Midekssa, Maggie Jewett, Megan Busch, Megan Wieger, Jordan Kamen, Brendon BakerUniversity of Michigan, Ann Arbor, MI, USA.
2:45 PM 381. Mobile Sliding Hydrogels with Tunable Stiffness Enhance MSC Osteogenesis in 3D via Mechanosensing. Georgios Mikos, Manish Ayushman, Xinming Tong, PhD, Sarah Jones, Fan Yang, PhD, Stanford University, Stanford, CA, USA.
3:00 PM 382. Reciprocal Cell-ECM Dynamics Drive Nematic Ordering of C2C12 Myotubes on Anisotropic Liquid Crystalline Polymer Networks. Nathaniel Skillin, BS, Katie Herbert, PhD, Bruce Kirkpatrick, BS, Grace Hach, Kemal Gunay, PhD, Frank DelRio, PhD, Ryan Khan, PhD, Kristi Anseth, PhD, Timothy White, PhD, University of Colorado Boulder, Boulder, CO, USA, Sandia National Laboratories, Albuquerque, NM, USA.
3:15 PM 383. Small Molecules to Modulate Hydrogel Gelation and Mechanics for Dynamic Organoid Culture. Aidan Gilchrist, PhD, Yueming Liu, Yuan Guan, PhD, Gary Peltz, MD, PhD, Sarah Heilshorn, PhD, Stanford Univeristy, Stanford, CA, USA.
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