10:15 AM 407. Mechanical Loading Unveils Calcium Handling Dysfunction in iPSC Micro-Heart Muscle Harboring Hypertrophic Cardiomyopathy Mutations. Jingxuan Guo, David Schuftan, Huanzhu Jiang, Druv Bhagavan, Lavanya Aryan, Nathaniel Huebsch, Washington University in St. Louis, University City, MO, USA.

10:30 AM 408. Microfluidic Bioprinting of Tough Hydrogel-based Vascular Conduits for Functional Blood Vessels. Xiao Kuang, Ph.D., Di Wang, PhD,, Sushila Maharjan, Yu Shrike Zhang, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, USA.

10:45 AM 409. Long-Term Performance of a Biodegradable Elastomer Based Vascular Graft Prepared by Metal Ligand Chelation in Rat/Sheep Carotid Artery Replacement and Pig CABG Models. Ying Chen, Anthony D'Amato, Ayla Musciano, Halle Welch, Cole Latvis, Iwijn Vlaminck,Yadong Wang. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA, 2Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

11:00 AM 410 Integrated Functional Analysis for Engineered Cardiac Organoids Enabled by Artificial Intelligence. Zhen Ma, Andrew Kowalczewski, Shiyang Sun, Plansky Hoang, Syracuse University, Syracuse, NY, USA.

11:15 AM 411. Matrix Mechanics Regulate Engineered Myocardial Microtissue Organization and Contractility. Samuel DePalma, Austin Stis, Darcy Huang, Javiera Jilberto, Christopher Davidson, PhD, Aamilah Chowdhury, Maggie Jewett, Adam Helms, MD, David Nordsletten, DPhil, Brendon Baker, PhD, University of Michigan, Ann Arbor, MI, USA.

11:30 AM 412. Connexin Rich Biomaterials Electrochemically Couple Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Nima Momtahan, Jeanne Stachowiak, Janet Zoldan,The University of Texas at Austin, Austin, , TX, USA.

11:45 AM 413. Hydrogel Assisted Double Molding of 3D Print Reveals Prestress Regulation of MicroHeart Muscle Electrophysiology. Daniel Simmons, David Schuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Mary Munsell, Brennan Kandalaft, Missy Pear, Nathaniel Huebsch, Washington University in St. Louis, St. Louis, MO, USA.

2:00 PM 414. High-Throughput Screening Identifies Hydrogel Conditions for Cardiomyocyte Differentiation and Maturation. Margot Amitrano, William Murphy, University of Wisconsin-Madison, Madison, WI, USA.