10:15 AM. 415. Novel Targeted Treatment of Coagulase-Mediated S. aureus Biofilms. Grant Scull, BS, Adrian Aligwekwe, Drew Koch, DVM, MS, Diplomate ACVS, Kimberly Nellenbach, PhD, Jennifer Sollinger, MS, Jessica Gilbertie, DVM, PhD, MS, Lauren Schnabel, DVM, PhD, Diplomate ACVS, Diplomate ACVSMR2, Ashley Brown, PhD, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, North Carolina State University, Raleigh, NC, USA.

10:30 AM 416. Efficacy of Saline Wash Plus Vancomycin/Tobramycin-Doped PVA Composite (PVA-VAN/TOB-P) in a Mouse Pouch Infection Model Implanted with 3D-Printed Porous Titanium Cylinders. David Markel, MD, Therese Bou-Akl, MD., PhD, Paula Dietz, MS, Bin Wu, MD, Weiping Ren, MD., PhD, Ascension Providence Hospital, Southfield, MI, USA, Wayne State University, Detroit, MI, USA, Virotech Co., Inc., Troy, MI, USA.

10:45 AM 417. Peptidomimetic Polyurethanes Inhibit Bacterial Biofilm Formation and Disrupt Surface Established Biofilms. Abraham Joy, Apoorva Vishwakarma, Zixi Chen, University of Akron, Akron, OH, USA.

11:00 AM 418. A Thy-1 Negative Inflammatory Fibroblast Subpopulation Emerges as a Key Determinant of Fibrotic Outcomes to Biomaterials. Daniel Abebayehu, PhD, Blaise Pfaff, Grace Bingham, Andrew Miller, Donald Griffin, PhD, Thomas Barker, PhD, University of Virginia, Charlottesville, VA, USA.

11:15 AM 419. The Surface Topography of Silicone Breast Implants Mediates the Foreign Body Response in Mice, Rabbits, and Humans. Joshua Doloff, PhD, Johns Hopkins University, Baltimore, MD, USA.

11:30 AM 420 Dynamic Profiling of Inflammatory Protease Biomarkers in Subcutaneous Host Response to Implanted Biomaterials. Thi Hong Anh Truong, Nam Nam, Tram Dang, PhD, Nanyang Technological University, Singapore, Singapore.

11:45 AM 421. The Role of Toll-Like Receptor 2 and 4 in the Innate Immune Cell Response to Biomaterials and the Foreign Body Response. Brittany Thompson, MS, Leila Saleh, PhD, Stephanie Bryant, PhD, University of Colorado, Boulder, Boulder, CO, USA.

12:00 PM 422. Attenuated Foreign Body Response to Subcutaneous Implants in Regenerative Spiny Mice. Michele Dill, Janak Gaire, PhD, Valentina Supper, Erika Moore, PhD, Chelsey Simmons, PhD, University of Florida, Gainesville, FL, USA.